Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow IL12Rb1 rightarrow Polyclonal IL12Rb1  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Pyridoxal phosphate phosphatase (PDXP) Recombinant Protein
 • alpha-L-iduronidase (IDUA) ELISA Kit
 • Thromboxane synthase (TXS) ELISA Kit
 • glucagon (GCG) ELISA Kit
 • CMP-N-acetylneuraminate-bet a-galactosamide-alpha-2,3-s ialylt... Recombinant Protein
 • Peptidyl-prolyl cis-trans isomerase FKBP4 Antibody
 • CP - Ceruloplasmin Antibody
 • ACV-A (Activin A) CLIA Kit
 • Antibacterial peptide PMAP-36 (PMAP36) Recombinant Protein
 • Helicobacter pylori, OMP Antibody
 • SIN3A Antibody
 • TFEB Antibody
 • 40S ribosomal protein S18 (RPS18) Antibody
 • cyclin E1 (CCNE1) ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-IL12Rb1 antibody :: anti-Human Interleukin 12 Receptor Beta 1 (IL12Rb1) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2018133 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment) anti-IL12Rb1 antibody
Unit / Price
  DISCONTINUED
You will be redirected to our replacement product
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interleukin 12 Receptor Beta 1 (IL12Rb1), Polyclonal Antibody

 Also Known As   

FITC-linked Antibody to Interleukin 12 Receptor Beta 1 (IL12Rb1)

 Product Gene Name   

anti-IL12Rb1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 Chromosome Location    Chromosome: 19; NC_000019.9 (18170371..18197806, complement). Location: 19p13.1
 OMIM    209950
 3D Structure    ModBase 3D Structure for P42701
Section Bar
 Clonality    Polyclonal
 Species Reactivity    Human
Section Bar
 Concentration    200ug/ml (lot specific)
Section Bar
Section Bar
 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-IL12Rb1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 Product Categories/Family for anti-IL12Rb1 antibody    FITC Antibody
 Applications Tested/Suitable for anti-IL12Rb1 antibody   

Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blot (WB)

Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for IL12Rb1. It may not necessarily be applicable to this product.
 NCBI GI #    119605060
 NCBI GeneID    3594
 NCBI Accession #    EAW84654.1 [Other Products]
Section Bar
 UniProt Primary Accession #    P42701 [Other Products]
 UniProt Secondary Accession #    Q8N6Q7; A8K308; B2RPF1; B7ZKK3 [Other Products]
 UniProt Related Accession #    P42701 [Other Products]
 Molecular Weight    73,109 Da
Table BarTOPTable Bar
 NCBI Official Full Name    interleukin 12 receptor, beta 1, isoform CRA_b
 NCBI Official Synonym Full Names    interleukin 12 receptor, beta 1
 NCBI Official Symbol    IL12RB1 [Similar Products]
 NCBI Official Synonym Symbols   
CD212; IL12RB; IL-12R-BETA1
[Similar Products]
 NCBI Protein Information    interleukin-12 receptor subunit beta-1; IL-12R subunit beta-1; IL-12 receptor beta component; IL-12 receptor subunit beta-1; interleukin-12 receptor beta-1 chain
 UniProt Protein Name    Interleukin-12 receptor subunit beta-1
 UniProt Synonym Protein Names   
IL-12 receptor beta component
 Protein Family    Interleukin-12 receptor
 UniProt Gene Name    IL12RB1 [Similar Products]
 UniProt Synonym Gene Names    IL12R; IL12RB; IL-12 receptor subunit beta-1; IL-12R subunit beta-1; IL-12R-beta-1; IL-12RB1 [Similar Products]
 UniProt Entry Name    I12R1_HUMAN
Section Bar
 NCBI Summary for IL12Rb1    The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Section Bar
 UniProt Comments for IL12Rb1    IL12RB1: Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade. Defects in IL12RB1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD); also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity, whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance. Belongs to the type I cytokine receptor family. Type 2 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: external side of plasma membrane

Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin-12 receptor activity; interleukin-23 receptor activity; interleukin-23 binding; interleukin-12 receptor binding

Biological Process: positive regulation of memory T cell differentiation; positive regulation of interferon-gamma production; peptidyl-tyrosine phosphorylation; positive regulation of T-helper 1 type immune response; positive regulation of T cell mediated cytotoxicity; cytokine and chemokine mediated signaling pathway; positive regulation of activated T cell proliferation; signal transduction; positive regulation of defense response to virus by host

Disease: Immunodeficiency 30
Table BarTOPTable Bar
 Research Articles on IL12Rb1    1. The IL1B gene -5839C > T and IL4R 1902A > G polymorphisms and IL12RB1 -1094A/-641C and TNF -1031 T/-863A/-857 T/-308 G/-238 G haplotypes were associated with malaria susceptibility.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-IL12Rb1 antibodyPathways associated with anti-IL12Rb1 antibody
 Reference Product  PubMed Publications
 IL12RB2 antibody  >49 publications with IL12Rb1 and IL12RB2
 IL12B antibody  >34 publications with IL12Rb1 and IL12B
 STAT1 antibody  >27 publications with IL12Rb1 and STAT1
 STAT4 antibody  >21 publications with IL12Rb1 and STAT4
 CD4 antibody  >19 publications with IL12Rb1 and CD4
 IL23A antibody  >16 publications with IL12Rb1 and IL23A
 IL23R antibody  >12 publications with IL12Rb1 and IL23R
 IFNG antibody  >10 publications with IL12Rb1 and IFNG
 IL12A antibody  >9 publications with IL12Rb1 and IL12A
 TYK2 antibody  >8 publications with IL12Rb1 and TYK2
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 IL12-mediated Signaling Events Pathway antibodies  IL12-mediated Signaling Events Pathway Diagram
 IL23-mediated Signaling Events Pathway antibodies  IL23-mediated Signaling Events Pathway Diagram
 IL27-mediated Signaling Events Pathway antibodies  IL27-mediated Signaling Events Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
Diseases associated with anti-IL12Rb1 antibodyOrgans/Tissues associated with anti-IL12Rb1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >26 publications with IL12Rb1 and Inflammation
 Mycobacterium Infections, Nontuberculous Antibodies  >13 publications with IL12Rb1 and Mycobacterium Infections, Nontuberculous
 Necrosis Antibodies  >12 publications with IL12Rb1 and Necrosis
 Disease Models, Animal Antibodies  >6 publications with IL12Rb1 and Disease Models, Animal
 Carcinoma Antibodies  >4 publications with IL12Rb1 and Carcinoma
 Weight Loss Antibodies  >2 publications with IL12Rb1 and Weight Loss
 Kidney Diseases Antibodies  >2 publications with IL12Rb1 and Kidney Diseases
 Liver Diseases Antibodies  >2 publications with IL12Rb1 and Liver Diseases
 Growth Disorders Antibodies  >2 publications with IL12Rb1 and Growth Disorders
 Atherosclerosis Antibodies  >1 publications with IL12Rb1 and Atherosclerosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >80 publications with IL12Rb1 and Blood
 Skin Antibodies  >16 publications with IL12Rb1 and Skin
 Lymph Antibodies  >12 publications with IL12Rb1 and Lymph
 Lymph Node Antibodies  >12 publications with IL12Rb1 and Lymph Node
 Lung Antibodies  >9 publications with IL12Rb1 and Lung
 Spleen Antibodies  >8 publications with IL12Rb1 and Spleen
 Liver Antibodies  >3 publications with IL12Rb1 and Liver
 Bone Marrow Antibodies  >3 publications with IL12Rb1 and Bone Marrow
 Kidney Antibodies  >3 publications with IL12Rb1 and Kidney
 Bone Antibodies  >3 publications with IL12Rb1 and Bone
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions