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anti-IL-2 antibody :: Sheep Interleukin 2 (IL-2) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS340208 anti-IL-2 antibody
Unit / Price
0.5 mg  /  $1,545 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interleukin 2 (IL-2), Polyclonal Antibody

 Also Known As   

Interleukin 2 (IL-2) Affinity Purified

 Product Synonym Names    IL-2; Interleukin-2; IL2;
 Product Gene Name   

anti-IL-2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    147680
 3D Structure    ModBase 3D Structure for P60568
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 Clonality    Polyclonal
 Host    Sheep
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 Form/Format    Affinity Purified Ig
 Concentration    >5mg/ml (U.V.abs @ 280nm) (lot specific)
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 Immunogen    Recombinant Human IL-2
 Buffer    20mM Phosphate, 150mM Sodium Chloride
 Preservative    0.09% Sodium Azide
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 Preparation and Storage    Upon delivery aliquot and store at -20 degree C. Avoid freeze / thaw cycles. Short term storage 2 - 8 degree C.
 ISO Certification    Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
 Other Notes    Small volumes of anti-IL-2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-IL-2 antibody

   Interleukin-2 is a pleiotropic cytokine produced primarily by mitogenic or antigen activated T lymphocytes. IL-2 plays a key role in T cell proliferation and promotes the proliferation, expansion and differentiation of a wide variety of antigen specific cells. Recombinant Interleukin-2 comprises a 133 amino acid fragment (21-153) corresponding to the mature Interleukin-2 protein and is expressed in E Coli with an amino-terminal hexahistidine tag. This product is for research use only and is not intended for diagnostic or therapeutic use.
 Product Categories/Family for anti-IL-2 antibody    Polyclonal Antibodies; Biochemical Markers; Proteins; Interleukin-2
 Applications Tested/Suitable for anti-IL-2 antibody   

ELISA (EIA), Western Blot (WB), Dot Blot (DB), Immunohistochemistry (IHC), Immunoassays, Development of Rapid tests and Other Immunoassay, Antibody Recognition Assays

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NCBI/Uniprot data below describe general gene information for IL-2. It may not necessarily be applicable to this product.
 NCBI GI #    512412
 NCBI GeneID    3558
 NCBI Accession #    CAA01199.1 [Other Products]
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 UniProt Primary Accession #    P60568 [Other Products]
 UniProt Secondary Accession #    P01585 [Other Products]
 UniProt Related Accession #    P60568 [Other Products]
 Molecular Weight    17,628 Da
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 NCBI Official Full Name    interleukin-2
 NCBI Official Synonym Full Names    interleukin 2
 NCBI Official Symbol    IL2 [Similar Products]
 NCBI Official Synonym Symbols   
IL-2; TCGF; lymphokine
[Similar Products]
 NCBI Protein Information    interleukin-2
 UniProt Protein Name    Interleukin-2
 UniProt Synonym Protein Names   
T-cell growth factor; TCGF; INN: Aldesleukin
 UniProt Gene Name    IL2 [Similar Products]
 UniProt Synonym Gene Names    IL-2; TCGF [Similar Products]
 UniProt Entry Name    IL2_HUMAN
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 NCBI Summary for IL-2    The protein encoded by this gene is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IL-2    IL2: Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells. A chromosomal aberration involving IL2 is found in a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(4;16)(q26;p13) with involves TNFRSF17. Belongs to the IL-2 family.

Protein type: Cytokine; Secreted, signal peptide; Secreted; Oncoprotein

Chromosomal Location of Human Ortholog: 4q26-q27

Cellular Component: extracellular region; extracellular space

Molecular Function: cytokine activity; growth factor activity; interleukin-2 receptor binding; kinase activator activity; Ras guanyl-nucleotide exchange factor activity

Biological Process: cell adhesion; cell-cell signaling; immune response; MAPKKK cascade; natural killer cell activation; negative regulation of apoptosis; negative regulation of B cell apoptosis; positive regulation of activated T cell proliferation; positive regulation of B cell proliferation; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of inflammatory response; positive regulation of interleukin-17 production; positive regulation of tissue remodeling; positive regulation of tyrosine phosphorylation of Stat5 protein; T cell differentiation
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Product References and Citations for anti-IL-2 antibody

   Fletcher, M. & Goldstein, A.L. (1987) Lymphokine Res. 6(1): 45- 57. Jelinek, D.F. et al., (1986) Eur. J. Immunol. 16(8): 925- 932.
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 Research Articles on IL-2    1. There was a significant association of IL2 rs6534349 polymorphism with increased asthma risk and high load M. pneumoniae infectionin the GG genotype. IL-2 serum expression levels were significantly higher in M. pneumoniae negative subjects.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IL-2 antibodyPathways associated with anti-IL-2 antibody
 Reference Product  PubMed Publications
 IL4 antibody  >428 publications with IL-2 and IL4
 FOXP3 antibody  >122 publications with IL-2 and FOXP3
 IL2RA antibody  >63 publications with IL-2 and IL2RA
 LCK antibody  >20 publications with IL-2 and LCK
 IL2RB antibody  >16 publications with IL-2 and IL2RB
 IL2RG antibody  >14 publications with IL-2 and IL2RG
 STAT5A antibody  >10 publications with IL-2 and STAT5A
 STAT5B antibody  >7 publications with IL-2 and STAT5B
 RELA antibody  >7 publications with IL-2 and RELA
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 AhR Pathway antibodies  AhR Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies  Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
 Calcium Signaling In The CD4+ TCR Pathway antibodies  Calcium Signaling In The CD4+ TCR Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
Diseases associated with anti-IL-2 antibodyOrgans/Tissues associated with anti-IL-2 antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >372 publications with IL-2 and Necrosis
 Inflammation Antibodies  >250 publications with IL-2 and Inflammation
 Leukemia Antibodies  >246 publications with IL-2 and Leukemia
 Melanoma Antibodies  >167 publications with IL-2 and Melanoma
 Neoplasms, Experimental Antibodies  >151 publications with IL-2 and Neoplasms, Experimental
 Kidney Diseases Antibodies  >118 publications with IL-2 and Kidney Diseases
 HIV Infections Antibodies  >89 publications with IL-2 and HIV Infections
 Kidney Neoplasms Antibodies  >78 publications with IL-2 and Kidney Neoplasms
 Lung Neoplasms Antibodies  >70 publications with IL-2 and Lung Neoplasms
 Neoplasm Metastasis Antibodies  >55 publications with IL-2 and Neoplasm Metastasis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2413 publications with IL-2 and Blood
 Uncharacterized Tissue Antibodies  >1 publications with IL-2 and Uncharacterized Tissue
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