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anti-IL34 antibody :: Rabbit Interleukin 34, IN Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS626769 anti-IL34 antibody
Unit / Price
0.1 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interleukin 34, IN (IL34), Polyclonal Antibody

 Also Known As   

Interleukin 34, IN (IL-34, C16orf77, chromosome 16 open reading frame 77, hypothetical protein MGC34647, MGC34647)

 Product Synonym Names    Anti -Interleukin 34, IN (IL-34, C16orf77, chromosome 16 open reading frame 77, hypothetical protein MGC34647, MGC34647)
 Product Gene Name   

anti-IL34 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 16; NC_000016.9 (70613798..70694585). Location: 16q22.1
 OMIM    612081
 3D Structure    ModBase 3D Structure for Q6ZMJ4
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Recognizes human IL-34. Species Crossreactivity: Mouse and rat.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in PBS, 0.02% sodium azide.
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 Immunogen    Synthetic peptide corresponding to 13aa from near the center of human IL-34.
 Positive Control    Storage and Stability: Human Brain Tissue Lysate
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-IL34 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-IL34 antibody

   Interleukin-34 (IL-34) was identified through a functional screening of a library of secreted proteins after transfection of an embryonic kidney cell line with recombinant cDNAs. Flow cytometry and monocyte viability assays demonstrated increased survival and/or proliferation of monocytes induced by IL-34 and specific binding of IL-34 to CD14+ monocytes. IL-34 is a second ligand to the colony stimulating factor (CSF)-1 receptor in addition to CSF1. Like CSF1, IL-34 stimulates phosphorylation of ERK1 and ERK2 in human monocytes and induces differentiation of bone marrow cells into macrophages. Despite its predicted molecular weight, IL-34 will often run at higher molecular weight in SDS-PAGE.
 Product Categories/Family for anti-IL34 antibody    Antibodies; Abs to Interleukin
 Applications Tested/Suitable for anti-IL34 antibody   

Western Blot (WB)

 Application Notes for anti-IL34 antibody    Suitable for use in Western Blot.
Dilution: Western Blot: 0.25-0.5ug/ml
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NCBI/Uniprot data below describe general gene information for IL34. It may not necessarily be applicable to this product.
 NCBI GI #    289666752
 NCBI GeneID    146433
 NCBI Accession #    NP_001166243.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001172772.1 [Other Products]
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 UniProt Primary Accession #    Q6ZMJ4 [Other Products]
 UniProt Secondary Accession #    Q8N6L2; B2RC28; B2Z4A8; B2ZC70 [Other Products]
 UniProt Related Accession #    Q6ZMJ4 [Other Products]
 Molecular Weight    27,482 Da [Similar Products]
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 NCBI Official Full Name    interleukin-34 isoform 1
 NCBI Official Synonym Full Names    interleukin 34
 NCBI Official Symbol    IL34 [Similar Products]
 NCBI Official Synonym Symbols   
IL-34; C16orf77; MGC34647
[Similar Products]
 NCBI Protein Information    interleukin-34; OTTHUMP00000174906
 UniProt Protein Name    Interleukin-34
 Protein Family    Interleukin
 UniProt Gene Name    IL34 [Similar Products]
 UniProt Synonym Gene Names    C16orf77 [Similar Products]
 UniProt Entry Name    IL34_HUMAN
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 NCBI Summary for IL34    Interleukin-34 is a cytokine that promotes the differentiation and viability of monocytes and macrophages through the colony-stimulating factor-1 receptor (CSF1R; MIM 164770) (Lin et al., 2008 [PubMed 18467591]).[supplied by OMIM]
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 UniProt Comments for IL34    IL34: Cytokine that promotes the proliferation, survival and differentiation of monocytes and macrophages. Promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. Plays an important role in the regulation of osteoclast proliferation and differentiation, and in the regulation of bone resorption. Signaling via CSF1R and its downstream effectors stimulates phosphorylation of MAPK1/ERK2 AND MAPK3/ERK1. Belongs to the IL-34 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Cytokine; Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: extracellular space

Molecular Function: growth factor activity; cytokine activity; macrophage colony stimulating factor receptor binding

Biological Process: positive regulation of cell proliferation; innate immune response; positive regulation of protein amino acid phosphorylation; inflammatory response
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 Research Articles on IL34    1. The different spatiotemporal expression of IL-34 and CSF-1 allows for complementary activation of the CSF-1R in developing and adult tissues.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Organs/Tissues associated with anti-IL34 antibody
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >1 publications with IL34 and Bone
 Embryonic Tissue Antibodies  >1 publications with IL34 and Embryonic Tissue
 Brain Antibodies  >1 publications with IL34 and Brain
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