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anti-IL5Ra antibody :: Rabbit anti-Human Interleukin 5 Receptor Alpha (IL5Ra) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2004743 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Western Blot
Unit / Price
0.01 mg  /  $130 +1 FREE 8GB USB
0.05 mg  /  $225 +1 FREE 8GB USB
0.1 mg  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interleukin 5 Receptor Alpha (IL5Ra), Polyclonal Antibody

 Also Known As   

Polyclonal Antibody to Interleukin 5 Receptor Alpha (IL5Ra)

 Product Gene Name   

anti-IL5Ra antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 3; NC_000003.11 (3108008..3152058, complement). Location: 3p26-p24
 OMIM    147851
 3D Structure    ModBase 3D Structure for Q01344
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The antibody is a rabbit polyclonal antibody raised against IL5Ra. It has been selected for its ability to recognize IL5Ra in immunohistochemical staining andwestern blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
 Concentration    200ug/ml (lot specific)
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 Immunogen    IL5Ra, Human
 Immunogen    Recombinant IL5Ra (Gly42~Cys182) with N4terminal His4Tag expressed in E.coli.
 UOM    50ug
 Accession No.    RPB510Hu01
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of anti-IL5Ra antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-IL5Ra antibody   

Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)

 Application Notes for anti-IL5Ra antibody    Western blotting: 1:50-400
Immunocytochemistry in formalin fixed cells: 1:50-500
Immunohistochemistry in formalin fixed frozen section: 1:50-500
Immunohistochemistry in paraffin section: 1:10-100
Enzyme-linked Immunosorbent Assay: 1:100-200
Optimal working dilutions must be determined by end user.
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 Western Blot of anti-IL5Ra antibody    anti-IL5Ra antibody Western Blot (WB) image
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NCBI/Uniprot data below describe general gene information for IL5Ra. It may not necessarily be applicable to this product.
 NCBI GI #    191175130
 NCBI GeneID    3568
 NCBI Accession #    BAG49561.1 [Other Products]
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 UniProt Primary Accession #    Q01344 [Other Products]
 UniProt Secondary Accession #    Q14633; Q15469; Q6ISX9; B3IU77; B4E2G0 [Other Products]
 UniProt Related Accession #    Q01344 [Other Products]
 Molecular Weight    47,685 Da
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 NCBI Official Full Name    interleukin 5 receptor alpha transcript variant 7
 NCBI Official Synonym Full Names    interleukin 5 receptor, alpha
 NCBI Official Symbol    IL5RA [Similar Products]
 NCBI Official Synonym Symbols   
IL5R; CD125; CDw125; HSIL5R3
[Similar Products]
 NCBI Protein Information    interleukin-5 receptor subunit alpha; CD125 antigen; IL-5R subunit alpha; IL-5 receptor subunit alpha; interleukin 5 receptor type 3; interleukin-5 receptor alpha chain
 UniProt Protein Name    Interleukin-5 receptor subunit alpha
 UniProt Synonym Protein Names   
CDw125
 Protein Family    Interleukin-5 receptor
 UniProt Gene Name    IL5RA [Similar Products]
 UniProt Synonym Gene Names    IL5R; IL-5 receptor subunit alpha; IL-5R subunit alpha; IL-5R-alpha; IL-5RA [Similar Products]
 UniProt Entry Name    IL5RA_HUMAN
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 NCBI Summary for IL5Ra    The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Several alternatively spliced transcript variants encoding four distinct isoforms have been reported. [provided by RefSeq, Jul 2011]
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 UniProt Comments for IL5Ra    IL5RA: This is the receptor for interleukin-5. The alpha chain binds to IL5. Belongs to the type I cytokine receptor family. Type 5 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 3p26-p24

Cellular Component: extracellular space; integral to membrane; plasma membrane

Molecular Function: protein binding; interleukin-5 receptor activity

Biological Process: regulation of interleukin-5 production; cell proliferation; inflammatory response to antigenic stimulus; signal transduction
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 Research Articles on IL5Ra    1. The MDR analysis showed a potential interaction of C1GALT1-330G/T (rs1008898) and IL5RA31+197A/G (rs340833) on the susceptibility of IgAN (P<0.001). Gene-gene interaction may have some influence on the susceptibility to IgA nephropathy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IL5Ra antibodyPathways associated with anti-IL5Ra antibody
 Reference Product  PubMed Publications
 CSF2RB antibody  >37 publications with IL5Ra and CSF2RB
 IL5 antibody  >24 publications with IL5Ra and IL5
 JAK2 antibody  >19 publications with IL5Ra and JAK2
 JAK1 antibody  >7 publications with IL5Ra and JAK1
 LYN antibody  >4 publications with IL5Ra and LYN
 PTPN11 antibody  >1 publications with IL5Ra and PTPN11
 GRB2 antibody  >1 publications with IL5Ra and GRB2
 SDCBP antibody  >1 publications with IL5Ra and SDCBP
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 IL-5 Signaling Pathway antibodies  IL-5 Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Inflammatory Response Pathway antibodies  Inflammatory Response Pathway Diagram
 Interleukin Receptor SHC Signaling Pathway antibodies  Interleukin Receptor SHC Signaling Pathway Diagram
 Interleukin-2 Signaling Pathway antibodies  Interleukin-2 Signaling Pathway Diagram
Diseases associated with anti-IL5Ra antibodyOrgans/Tissues associated with anti-IL5Ra antibody
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >51 publications with IL5Ra and Immune System Diseases
 Asthma Antibodies  >47 publications with IL5Ra and Asthma
 Hypersensitivity Antibodies  >39 publications with IL5Ra and Hypersensitivity
 Inflammation Antibodies  >33 publications with IL5Ra and Inflammation
 Lung Diseases Antibodies  >31 publications with IL5Ra and Lung Diseases
 Necrosis Antibodies  >8 publications with IL5Ra and Necrosis
 Bone Marrow Diseases Antibodies  >8 publications with IL5Ra and Bone Marrow Diseases
 Brain Diseases Antibodies  >3 publications with IL5Ra and Brain Diseases
 Carcinoma Antibodies  >3 publications with IL5Ra and Carcinoma
 Neoplasms, Experimental Antibodies  >1 publications with IL5Ra and Neoplasms, Experimental
 Organ/Tissue Name  Pubmed Publications
 Bone Antibodies  >22 publications with IL5Ra and Bone
 Lung Antibodies  >19 publications with IL5Ra and Lung
 Skin Antibodies  >7 publications with IL5Ra and Skin
 Brain Antibodies  >4 publications with IL5Ra and Brain
 Trachea Antibodies  >1 publications with IL5Ra and Trachea
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