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anti-IL6 antibody :: Rabbit anti-Human Interleukin-6 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9416128
Western Blot (WB)
Unit / Price
0.1 mL  /  $320 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interleukin-6 (IL6), Polyclonal Antibody

 Also Known As   

Interleukin-6 Polyclonal Antibody

 Product Synonym Names    B-cell stimulatory factor 2; BSF-2; CTL differentiation factor; CDF; Hybridoma growth factor; Interferon beta-2; IFN-beta-2
 Product Gene Name   

anti-IL6 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    147620
 3D Structure    ModBase 3D Structure for P05231
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The antibody detects endogenous level of total Interleukin-6 polyclonal antibody.
 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation purified
 Form/Format    Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Concentration    1.0 mg/ml (lot specific)
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 Immunogen    Recombinant Human Interleukin-6 protein
 Immunogen Type    Protein
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 Preparation and Storage    Store at -20 degree C
 Other Notes    Small volumes of anti-IL6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-IL6 antibody

   Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation.It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoeitic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance.
 Product Categories/Family for anti-IL6 antibody    Total protein Ab
 Applications Tested/Suitable for anti-IL6 antibody   

Western Blot (WB)

 Application Notes for anti-IL6 antibody    Western Blot: 1:500 - 1:1000
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 Western Blot (WB) of anti-IL6 antibody    All lanes: Interleukin-6 antibody at 2ug/ml
anti-IL6 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for IL6. It may not necessarily be applicable to this product.
 NCBI GI #    10834984
 NCBI GeneID    3569
 NCBI Accession #    NP_000591.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000600.4 [Other Products]
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 UniProt Primary Accession #    P05231 [Other Products]
 UniProt Secondary Accession #    Q9UCU2; Q9UCU3; Q9UCU4 [Other Products]
 UniProt Related Accession #    P05231 [Other Products]
 Molecular Weight    23,718 Da [Similar Products]
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 NCBI Official Full Name    interleukin-6 isoform 1
 NCBI Official Synonym Full Names    interleukin 6
 NCBI Official Symbol    IL6 [Similar Products]
 NCBI Official Synonym Symbols   
CDF; HGF; HSF; BSF2; IL-6; BSF-2; IFNB2; IFN-beta-2
[Similar Products]
 NCBI Protein Information    interleukin-6
 UniProt Protein Name    Interleukin-6
 UniProt Synonym Protein Names   
B-cell stimulatory factor 2; BSF-2; CTL differentiation factor; CDF; Hybridoma growth factor; Interferon beta-2; IFN-beta-2
 Protein Family    Interleukin
 UniProt Gene Name    IL6 [Similar Products]
 UniProt Synonym Gene Names    IFNB2; IL-6; BSF-2; CDF; IFN-beta-2 [Similar Products]
 UniProt Entry Name    IL6_HUMAN
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 UniProt Comments for IL6    IL6: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ). An inflammatory articular disorder with systemic- onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men. Belongs to the IL-6 superfamily.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 7p21

Cellular Component: extracellular region; extracellular space; interleukin-6 receptor complex

Molecular Function: cytokine activity; growth factor activity; interleukin-6 receptor binding; protein binding

Biological Process: activation of NF-kappaB transcription factor; acute-phase response; cytokine and chemokine mediated signaling pathway; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; defense response to virus; endocrine pancreas development; hepatic immune response; humoral immune response; inflammatory response; monocyte chemotaxis; negative regulation of apoptosis; negative regulation of bone resorption; negative regulation of chemokine biosynthetic process; negative regulation of collagen biosynthetic process; neurite development; neutrophil apoptosis; neutrophil mediated immunity; platelet activation; positive regulation of acute inflammatory response; positive regulation of apoptosis; positive regulation of B cell activation; positive regulation of cell proliferation; positive regulation of chemokine production; positive regulation of immunoglobulin secretion; positive regulation of interleukin-6 production; positive regulation of JAK-STAT cascade; positive regulation of leukocyte chemotaxis; positive regulation of MAPKKK cascade; positive regulation of osteoblast differentiation; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of smooth muscle cell proliferation; positive regulation of T cell proliferation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; positive regulation of translation; positive regulation of tyrosine phosphorylation of Stat3 protein; regulation of angiogenesis; response to glucocorticoid stimulus

Disease: Arteriovenous Malformations Of The Brain; Inflammatory Bowel Disease 1; Kaposi Sarcoma, Susceptibility To; Rheumatoid Arthritis, Systemic Juvenile
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IL6 antibodyPathways associated with anti-IL6 antibody
 Reference Product  PubMed Publications
 JUN antibody  >821 publications with IL6 and JUN
 STAT3 antibody  >597 publications with IL6 and STAT3
 IL6R antibody  >159 publications with IL6 and IL6R
 STAT1 antibody  >96 publications with IL6 and STAT1
 SOCS3 antibody  >75 publications with IL6 and SOCS3
 IL6ST antibody  >64 publications with IL6 and IL6ST
 FOS antibody  >62 publications with IL6 and FOS
 NFKB1 antibody  >47 publications with IL6 and NFKB1
 OSM antibody  >32 publications with IL6 and OSM
 CEBPB antibody  >12 publications with IL6 and CEBPB
 Products by Pathway  Pathway Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 AGE-RAGE Signaling Pathway In Diabetic Complications antibodies  AGE-RAGE Signaling Pathway In Diabetic Complications Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Cellular Senescence Pathway antibodies  Cellular Senescence Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
Diseases associated with anti-IL6 antibodyOrgans/Tissues associated with anti-IL6 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >3082 publications with IL6 and Inflammation
 Necrosis Antibodies  >2199 publications with IL6 and Necrosis
 Autoimmune Diseases Antibodies  >541 publications with IL6 and Autoimmune Diseases
 Skin Diseases Antibodies  >395 publications with IL6 and Skin Diseases
 Arthritis, Rheumatoid Antibodies  >328 publications with IL6 and Arthritis, Rheumatoid
 Myocardial Ischemia Antibodies  >279 publications with IL6 and Myocardial Ischemia
 Atherosclerosis Antibodies  >278 publications with IL6 and Atherosclerosis
 Breast Neoplasms Antibodies  >154 publications with IL6 and Breast Neoplasms
 Diabetes Mellitus, Type 2 Antibodies  >149 publications with IL6 and Diabetes Mellitus, Type 2
 Ischemia Antibodies  >141 publications with IL6 and Ischemia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >3764 publications with IL6 and Blood
 Vascular Antibodies  >821 publications with IL6 and Vascular
 Bone Antibodies  >511 publications with IL6 and Bone
 Lung Antibodies  >507 publications with IL6 and Lung
 Brain Antibodies  >477 publications with IL6 and Brain
 Muscle Antibodies  >371 publications with IL6 and Muscle
 Kidney Antibodies  >332 publications with IL6 and Kidney
 Connective Tissue Antibodies  >254 publications with IL6 and Connective Tissue
 Skin Antibodies  >231 publications with IL6 and Skin
 Eye Antibodies  >160 publications with IL6 and Eye
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