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anti-ILF2 antibody :: Rabbit anti-Human Interleukin enhancer-binding factor 2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7000580
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interleukin enhancer-binding factor 2 (ILF2), Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human Interleukin enhancer-binding factor 2 polyclonal Antibody

 Product Synonym Names    Interleukin enhancer-binding factor 2 protein; ILF2; NF45; PRO3063 ; Nuclear factor of activated T-cells 45 kDa
 Product Gene Name   

anti-ILF2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    603181
 3D Structure    ModBase 3D Structure for Q12905
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation purified
 Form/Format    Liquid
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 Immunogen    Recombinant human Interleukin enhancer-binding factor 2 protein
 Conjugation    Non-conjugated
 Storage Buffer    Preservative: 0.03% Proclin 300; Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery, aliquot and store at -20 degree C or -80 degree C.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-ILF2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ILF2 antibody

   EIF3S2 is the largest of the EIFs. It consists of at least 10 nonidentical subunits in mammals. In S. cerevisiae the p39 subunit contains WD repeats; these are thought to mediate protein-protein interactions. The p39 protein appears to be essential for maintaining the integrity of the yeast EIF3 complex. The mammalian EIF3-p36 subunit is homologous to yeast p39.

Nuclear factor of activated T-cells (NFAT) is a transcription factor required for T-cell expression of the interleukin 2 gene. NFAT binds to a sequence in the interleukin 2 gene enhancer known as the antigen receptor response element 2. In addition, NFAT can bind RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. NFAT is a heterodimer of 45 kDa and 90 kDa proteins, the smaller of which is the product of this gene. The encoded protein binds strongly to the 90 kDa protein and stimulates its ability to enhance gene expression.
 Product Categories/Family for anti-ILF2 antibody    Transcription
 Applications Tested/Suitable for anti-ILF2 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-ILF2 antibody    Recommended dilution: WB:1:500-2000, IHC:1:20-1:200
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 Western Blot (WB) of anti-ILF2 antibody    Western blot
All lanes: Interleukin enhancer-binding factor 2 polyclonal Antibody at 2ug/ml+293T whole cell lysate
Secondary
Goat polyclonal to Rabbit IgG at 1/15000 dilution
Predicted band size: 43 kDa
Observed band size: 43 kDa

anti-ILF2 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ILF2 antibody    Immunohistochemistry of paraffin-embedded human kidney using MBS7000580 at dilution of 1:100
anti-ILF2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ILF2. It may not necessarily be applicable to this product.
 NCBI GI #    392513662
 NCBI GeneID    3608
 NCBI Accession #    NP_001254738.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001267809.1 [Other Products]
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 UniProt Primary Accession #    Q12905 [Other Products]
 UniProt Secondary Accession #    Q5SR10; Q5SR11; Q7L7R3; Q9BWD4; Q9P1N0; A6NDB0; B2R8G7 [Other Products]
 UniProt Related Accession #    Q12905 [Other Products]
 Molecular Weight    43,062 Da
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 NCBI Official Full Name    interleukin enhancer-binding factor 2 isoform 2
 NCBI Official Synonym Full Names    interleukin enhancer binding factor 2
 NCBI Official Symbol    ILF2 [Similar Products]
 NCBI Official Synonym Symbols   
NF45; PRO3063
[Similar Products]
 NCBI Protein Information    interleukin enhancer-binding factor 2
 UniProt Protein Name    Interleukin enhancer-binding factor 2
 UniProt Synonym Protein Names   
Nuclear factor of activated T-cells 45 kDa
 Protein Family    Interleukin enhancer-binding factor
 UniProt Gene Name    ILF2 [Similar Products]
 UniProt Synonym Gene Names    NF45 [Similar Products]
 UniProt Entry Name    ILF2_HUMAN
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 NCBI Summary for ILF2    The protein encoded by this gene is a transcription factor required for T-cell expression of the interleukin 2 gene. It also binds RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. The encoded 45 kDa protein (NF45, ILF2) forms a complex with the 90 kDa interleukin enhancer-binding factor 3 (NF90, ILF3), and this complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm, to repair DNA breaks by nonhomologous end joining, and to negatively regulate the microRNA processing pathway. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. Alternative splicing results in multiple transcript variants. Related pseudogenes have been found on chromosomes 3 and 14. [provided by RefSeq, Dec 2014]
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 UniProt Comments for ILF2    ILF2: Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA.

Protein type: RNA-binding; Nucleolus; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 1q21.3

Cellular Component: cytoplasm; membrane; nucleolus; nucleoplasm; nucleus; ribonucleoprotein complex

Molecular Function: ATP binding; DNA binding; double-stranded RNA binding; protein binding; transferase activity

Biological Process: immune response; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent
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 Research Articles on ILF2    1. The RNA binding complexes NF45-NF90 and NF45-NF110 associate dynamically with the c-fos gene and function as transcriptional coactivators.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ILF2 antibodyDiseases associated with anti-ILF2 antibody
 Reference Product  PubMed Publications
 ILF3 antibody  >18 publications with ILF2 and ILF3
 XRCC5 antibody  >2 publications with ILF2 and XRCC5
 PRKDC antibody  >2 publications with ILF2 and PRKDC
 YBX1 antibody  >1 publications with ILF2 and YBX1
 DHX9 antibody  >1 publications with ILF2 and DHX9
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >3 publications with ILF2 and Nervous System Diseases
 Liver Diseases Antibodies  >2 publications with ILF2 and Liver Diseases
 Kidney Diseases Antibodies  >2 publications with ILF2 and Kidney Diseases
 Atrophy Antibodies  >2 publications with ILF2 and Atrophy
 Cell Transformation, Neoplastic Antibodies  >1 publications with ILF2 and Cell Transformation, Neoplastic
 Liver Neoplasms Antibodies  >1 publications with ILF2 and Liver Neoplasms
 Adenocarcinoma Antibodies  >1 publications with ILF2 and Adenocarcinoma
 Infertility, Male Antibodies  >1 publications with ILF2 and Infertility, Male
 Carcinoma, Hepatocellular Antibodies  >1 publications with ILF2 and Carcinoma, Hepatocellular
 Uterine Neoplasms Antibodies  >1 publications with ILF2 and Uterine Neoplasms
Organs/Tissues associated with anti-ILF2 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9 publications with ILF2 and Blood
 Brain Antibodies  >6 publications with ILF2 and Brain
 Kidney Antibodies  >5 publications with ILF2 and Kidney
 Liver Antibodies  >5 publications with ILF2 and Liver
 Spleen Antibodies  >5 publications with ILF2 and Spleen
 Testis Antibodies  >5 publications with ILF2 and Testis
 Heart Antibodies  >3 publications with ILF2 and Heart
 Ovary Antibodies  >2 publications with ILF2 and Ovary
 Lung Antibodies  >2 publications with ILF2 and Lung
 Muscle Antibodies  >2 publications with ILF2 and Muscle
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