NP_001254738.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
43,062 Da
NCBI Official Full Name
interleukin enhancer-binding factor 2 isoform 2
NCBI Official Synonym Full Names
interleukin enhancer binding factor 2
NCBI Protein Information
interleukin enhancer-binding factor 2
UniProt Protein Name
Interleukin enhancer-binding factor 2
UniProt Synonym Protein Names
Nuclear factor of activated T-cells 45 kDa
UniProt Synonym Gene Names
UniProt Entry Name
ILF2_HUMAN
NCBI Summary for ILF2
The protein encoded by this gene is a transcription factor required for T-cell expression of the interleukin 2 gene. It also binds RNA and is an essential component for encapsidation and protein priming of hepatitis B viral polymerase. The encoded 45 kDa protein (NF45, ILF2) forms a complex with the 90 kDa interleukin enhancer-binding factor 3 (NF90, ILF3), and this complex has been shown to affect the redistribution of nuclear mRNA to the cytoplasm, to repair DNA breaks by nonhomologous end joining, and to negatively regulate the microRNA processing pathway. Knockdown of NF45 or NF90 protein retards cell growth, possibly by inhibition of mRNA stabilization. Alternative splicing results in multiple transcript variants. Related pseudogenes have been found on chromosomes 3 and 14. [provided by RefSeq, Dec 2014]
UniProt Comments for ILF2
ILF2: Appears to function predominantly as a heterodimeric complex with ILF3. This complex may regulate transcription of the IL2 gene during T-cell activation. It can also promote the formation of stable DNA-dependent protein kinase holoenzyme complexes on DNA.
Protein type: Nucleolus; Transcription, coactivator/corepressor; RNA-binding
Chromosomal Location of Human Ortholog: 1q21.3
Cellular Component: cytoplasm; membrane; nucleolus; nucleoplasm; nucleus; ribonucleoprotein complex
Molecular Function: ATP binding; DNA binding; double-stranded RNA binding; protein binding; transferase activity
Biological Process: immune response; positive regulation of transcription, DNA-dependent; transcription, DNA-dependent
Research Articles on ILF2
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Products associated with anti-ILF2 antibody
Diseases associated with anti-ILF2 antibody
Organs/Tissues associated with anti-ILF2 antibody
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