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anti-IGJ antibody :: Rabbit J-chain Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS301836
Immunohistochemistry (IHC)
Unit / Price
0.1 mL (Concentrate)  /  $180 +1 FREE 8GB USB
7 mL (RTU)  /  $300 +1 FREE 8GB USB
0.5 mL (Concentrate)  /  $335 +1 FREE 8GB USB
1 mL (Concentrate)  /  $505 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

J-chain (IGJ), Polyclonal Antibody

 Also Known As   

Rabbit Anti-Human J-chain Polyclonal Antibody

 Product Gene Name   

anti-IGJ antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    147790
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
Predicted Reactivity: Dog, Pig
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 Form/Format    0.1 ml immunogen affinity purified rabbit polyclonal antibody in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.
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 Immunogen    Synthetic peptide derived from near C-terminus of human J-chain protein.
 Control Tissue    Tonsil
 Cellular Localization    Cytoplasm
 Entrez Gene Code    3512
 Pathway    Lymphocyte Signaling
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 Preparation and Storage    Store at 2-8 degree C. Do not freeze. The user must validate any other storage conditions. When properly stored, the reagent is stable to the date indicated on the label. Do not use the reagent beyond the expiration date. There are no definitive signs to indicate instability of this product; therefore, positive and negative controls should be tested simultaneously with unknown specimens. If unexpected results are observed which cannot be explained by variations in laboratory procedures and a problem with the reagent is suspected, contact Technical Support.
 Other Notes    Small volumes of anti-IGJ antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-IGJ antibody

   J chain is a small glycopeptide with a molecular weight of 15kDa. It is structurally unrelated to heavy or light chains, but is synthesized by all plasma cells that secrete polymeric immunoglobulins. J chain is linked to IgA and IgM by disulfide bonds, however, it has been detected in IgG- and IgD-containing cells. J chains are present in a large proportion of the immunoglobulin-positive cells in the germinal centers of the tonsils and lymph nodes. B cells discrete J chain at an early stage of differentiation with the expression persisting in those cells destined to produce IgA or IgM.
 Applications Tested/Suitable for anti-IGJ antibody   

Immunohistochemistry (IHC) Paraffin

 Application Notes for anti-IGJ antibody    Immunohistochemistry Procedure
Specimen Preparation: Formalin-fixed, paraffin-embedded tissues are suitable for use with this primary antibody. Deparaffinization: Deparaffinize slides using xylene or xylene alternative and graded alcohols. Antibody Dilution: If using the concentrate format of this product, dilute the antibody 1:100. The dilutions are estimates; actual results may differ because of variability in methods and protocols. Antigen Retrieval: Boil tissue section in 10mM citrate, pH 6.0 for 10 min followed by cooling at room temperature for 20 min. Primary Antibody Incubation: Incubate for 30 minutes at room temperature. Slide Washing: Slides must be washed in between steps. Rinse slides with PBS/0.05% Tween. Visualization: Detect the antibody as instructed by the instructions provided with the visualization system.
Immunohistochemistry Dilution: 1:100
IHC Positive Control: Tonsil
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 Immunohistochemistry (IHC) of anti-IGJ antibody    Human tonsil stained with anti-J-chain antibody
anti-IGJ antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for IGJ. It may not necessarily be applicable to this product.
 NCBI GI #    21489959
 NCBI GeneID    3512
 NCBI Accession #    NP_653247.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_144646.3 [Other Products]
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 UniProt Related Accession #    P01591 [Other Products]
 Molecular Weight    15 kDa [Similar Products]
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 NCBI Official Full Name    immunoglobulin J chain
 NCBI Official Synonym Full Names    immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
 NCBI Official Symbol    IGJ [Similar Products]
 NCBI Official Synonym Symbols   
JCH; IGCJ
[Similar Products]
 NCBI Protein Information    immunoglobulin J chain; IgJ chain
 UniProt Protein Name    Immunoglobulin J chain
 UniProt Gene Name    IGJ [Similar Products]
 UniProt Synonym Gene Names    IGCJ [Similar Products]
 UniProt Entry Name    IGJ_HUMAN
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 UniProt Comments for IGJ    IGJ: Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4q21

Cellular Component: extracellular space; extracellular region

Molecular Function: peptidoglycan binding; protein homodimerization activity; IgA binding; phosphatidylcholine binding; antigen binding; single-stranded DNA binding

Biological Process: positive regulation of protein oligomerization; retinal homeostasis; adaptive immune response; glomerular filtration; antibacterial humoral response; innate immune response; immune response
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 Research Articles on IGJ    1. TLR2 ligands induce CCR9 and CCR10 expression by circulating B-cells and increase their chemotaxis. TLR2 stimulation also induced J chain and IgA production demonstrating the induction of mucosal-like antibody secreting cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IGJ antibodyDiseases associated with anti-IGJ antibody
 Reference Product  PubMed Publications
 PAX5 antibody  >2 publications with IGJ and PAX5
 CBFB antibody  >1 publications with IGJ and CBFB
 TNFRSF17 antibody  >1 publications with IGJ and TNFRSF17
 IL2 antibody  >1 publications with IGJ and IL2
 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >1 publications with IGJ and Congenital Abnormalities
 Heart Diseases Antibodies  >1 publications with IGJ and Heart Diseases
 Neoplasms, Experimental Antibodies  >1 publications with IGJ and Neoplasms, Experimental
 Liver Diseases Antibodies  >1 publications with IGJ and Liver Diseases
 Necrosis Antibodies  >1 publications with IGJ and Necrosis
Organs/Tissues associated with anti-IGJ antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >16 publications with IGJ and Blood
 Spleen Antibodies  >3 publications with IGJ and Spleen
 Bone Antibodies  >3 publications with IGJ and Bone
 Stomach Antibodies  >2 publications with IGJ and Stomach
 Liver Antibodies  >2 publications with IGJ and Liver
 Kidney Antibodies  >2 publications with IGJ and Kidney
 Bone Marrow Antibodies  >2 publications with IGJ and Bone Marrow
 Mammary Gland Antibodies  >1 publications with IGJ and Mammary Gland
 Pancreas Antibodies  >1 publications with IGJ and Pancreas
 Adrenal Gland Antibodies  >1 publications with IGJ and Adrenal Gland
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