NP_653247.1
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NCBI GenBank Nucleotide #
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UniProt Related Accession #
NCBI Official Full Name
immunoglobulin J chain
NCBI Official Synonym Full Names
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
NCBI Official Synonym Symbols
NCBI Protein Information
immunoglobulin J chain; IgJ chain
UniProt Protein Name
Immunoglobulin J chain
UniProt Synonym Gene Names
UniProt Entry Name
IGJ_HUMAN
UniProt Comments for IGJ
IGJ: Serves to link two monomer units of either IgM or IgA. In the case of IgM, the J chain-joined dimer is a nucleating unit for the IgM pentamer, and in the case of IgA it induces larger polymers. It also help to bind these immunoglobulins to secretory component.
Protein type: Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 4q21
Cellular Component: extracellular space; extracellular region
Molecular Function: peptidoglycan binding; protein homodimerization activity; IgA binding; phosphatidylcholine binding; antigen binding; single-stranded DNA binding
Biological Process: positive regulation of protein oligomerization; retinal homeostasis; adaptive immune response; glomerular filtration; antibacterial humoral response; innate immune response; immune response
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Products associated with anti-IGJ antibody
Diseases associated with anti-IGJ antibody
Organs/Tissues associated with anti-IGJ antibody
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