AAB96974.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Calculated MW: 38 Observed MW: 38
NCBI Official Full Name
JAB1
NCBI Official Synonym Symbols
AJH1; ARABIDOPSIS JAB1 HOMOLOG 1; COP9 signalosome 5A; CSN5; CSN5A; F19G10.12; F19G10_12; JAB1; PUTATIVE JUN KINASE ACTIVATOR [Similar Products]
NCBI Protein Information
COP9 signalosome complex subunit 5a
UniProt Protein Name
COP9 signalosome complex subunit 5b
UniProt Synonym Protein Names
Jun activation domain-binding homolog 1
UniProt Synonym Gene Names
UniProt Entry Name
CSN5B_ARATH
NCBI Summary for JAB1
AJH1 encodes a protein similar to JAB1, a specific mammalian coactivator of AP-1 transcription. Encodes a subunit of the COP9 complex that is involved in protein deneddylation. Plants with mutations in CSN5A and CSN5B have a de-etiolated phenotype.
UniProt Comments for JAB1
Probable protease subunit of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes such as photomorphogenesis and auxin and jasmonate responses. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. In the complex, it probably acts as the catalytic center that mediates the cleavage of Nedd8 from cullins. It however has no metalloprotease activity by itself and requires the other subunits of the CSN complex (). The CSN complex is involved in repression of photomorphogenesis in darkness by regulating the activity of COP1-containing Ubl ligase complexes. The complex is also required for degradation of PSIAA6 by regulating the activity of the Ubl ligase SCF-TIR complex.
Research Articles on JAB1
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Products associated with anti-JAB1 antibody
Pathways associated with anti-JAB1 antibody
Organs/Tissues associated with anti-JAB1 antibody
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