NP_001274366.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
58,370 Da
NCBI Official Full Name
protein Jade-1 isoform 3
NCBI Official Synonym Full Names
jade family PHD finger 1
NCBI Official Synonym Symbols
NCBI Protein Information
protein Jade-1
UniProt Protein Name
Protein Jade-1
UniProt Synonym Protein Names
Jade family PHD finger protein 1; PHD finger protein 17
UniProt Synonym Gene Names
UniProt Entry Name
JADE1_HUMAN
UniProt Comments for JADE1
JADE1: Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Transcriptional coactivator it may also promote acetylation of nucleosomal histone H4 by KAT5. Promotes apoptosis. May act as a renal tumor suppressor. Belongs to the JADE family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Tumor suppressor
Chromosomal Location of Human Ortholog: 4q26-q27
Cellular Component: nucleoplasm; intercellular bridge; cytoplasm; plasma membrane; nucleus; histone acetyltransferase complex
Molecular Function: protein binding; zinc ion binding
Biological Process: establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; apoptosis; response to stress; positive regulation of transcription from RNA polymerase II promoter; negative regulation of cell growth
Research Articles on JADE1
Precautions
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Products associated with anti-JADE1 antibody
Pathways associated with anti-JADE1 antibody
Diseases associated with anti-JADE1 antibody
Organs/Tissues associated with anti-JADE1 antibody
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