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anti-JAG1 antibody :: Rabbit JAG1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2528755 anti-JAG1 antibody
Unit / Price
0.06 mL  /  $195 +1 FREE 8GB USB
0.12 mL  /  $270 +1 FREE 8GB USB
0.2 mL  /  $435 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

JAG1, Polyclonal Antibody

 Also Known As   

JAG1 Antibody

 Product Synonym Names    AGS; AHD; AWS; CD339; HJ1; JAGL1; MGC104644
 Product Gene Name   

anti-JAG1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    118450
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
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 Immunogen    Fusion protein of JAG1
 Calculated Molecular Weight: 1218aa; 134kd   
 Buffer    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-34473 / sc-34474 / sc-11376 / sc-8303
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles
 Other Notes    Small volumes of anti-JAG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-JAG1 antibody   

ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for JAG1. It may not necessarily be applicable to this product.
 NCBI GI #    2228793
 NCBI GeneID    182
 NCBI Accession #    AAC51731.1 [Other Products]
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 UniProt Secondary Accession #    O14902; O15122; Q15816; A0AV43; B4DYR1; E9PCF9 [Other Products]
 UniProt Related Accession #    P78504 [Other Products]
 Molecular Weight    116,579 Da
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 NCBI Official Full Name    Jagged1
 NCBI Official Synonym Full Names    jagged 1
 NCBI Official Symbol    JAG1 [Similar Products]
 NCBI Official Synonym Symbols   
AGS; AHD; AWS; HJ1; CD339; JAGL1
[Similar Products]
 NCBI Protein Information    protein jagged-1
 UniProt Protein Name    Protein jagged-1
 UniProt Synonym Protein Names   
CD_antigen: CD339
 Protein Family    Protein jagged
 UniProt Gene Name    JAG1 [Similar Products]
 UniProt Synonym Gene Names    JAGL1; Jagged1; hJ1 [Similar Products]
 UniProt Entry Name    JAG1_HUMAN
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 NCBI Summary for JAG1    The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008]
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 UniProt Comments for JAG1    JAG1: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Interacts with NOTCH2 and NOTCH3. Interacts with NOTCH1 (in the presence of calcium ions). Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 20p12.1-p11.23

Cellular Component: membrane; integral to plasma membrane; apical part of cell; extracellular region; plasma membrane

Molecular Function: protein binding; growth factor activity; calcium ion binding; structural molecule activity; Notch binding

Biological Process: endothelial cell differentiation; nervous system development; Notch signaling pathway; positive regulation of myeloid cell differentiation; T cell mediated immunity; Notch receptor processing; auditory receptor cell differentiation; cell fate determination; negative regulation of fat cell differentiation; regulation of cell migration; regulation of cell proliferation; keratinocyte differentiation; myoblast differentiation; positive regulation of osteoblast differentiation; negative regulation of neuron differentiation; response to muramyl dipeptide; morphogenesis of an epithelial sheet; hemopoiesis; positive regulation of transcription from RNA polymerase II promoter; blood vessel remodeling; angiogenesis; positive regulation of Notch signaling pathway

Disease: Tetralogy Of Fallot; Alagille Syndrome 1
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 Research Articles on JAG1    1. High cytoplasmic Jagged1 expression is associated with laryngeal cancer.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-JAG1 antibodyPathways associated with anti-JAG1 antibody
 Reference Product  PubMed Publications
 NOTCH1 antibody  >88 publications with JAG1 and NOTCH1
 NOTCH2 antibody  >60 publications with JAG1 and NOTCH2
 DLL1 antibody  >34 publications with JAG1 and DLL1
 NOTCH3 antibody  >34 publications with JAG1 and NOTCH3
 HES5 antibody  >19 publications with JAG1 and HES5
 ADAM10 antibody  >2 publications with JAG1 and ADAM10
 MIB1 antibody  >2 publications with JAG1 and MIB1
 UBC antibody  >1 publications with JAG1 and UBC
 Products by Pathway  Pathway Diagram
 Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies  Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram
 Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies  Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
 Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway antibodies  Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 FBXW7 Mutants And NOTCH1 In Cancer Pathway antibodies  FBXW7 Mutants And NOTCH1 In Cancer Pathway Diagram
 NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway antibodies  NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway Diagram
 Notch Signaling Pathway antibodies  Notch Signaling Pathway Diagram
Diseases associated with anti-JAG1 antibodyOrgans/Tissues associated with anti-JAG1 antibody
 Disease Name  Pubmed Publications
 Alagille Syndrome Antibodies  >127 publications with JAG1 and Alagille Syndrome
 Liver Diseases Antibodies  >108 publications with JAG1 and Liver Diseases
 Heart Defects, Congenital Antibodies  >108 publications with JAG1 and Heart Defects, Congenital
 Facies Antibodies  >32 publications with JAG1 and Facies
 Heart Diseases Antibodies  >29 publications with JAG1 and Heart Diseases
 Carcinoma Antibodies  >28 publications with JAG1 and Carcinoma
 Breast Neoplasms Antibodies  >23 publications with JAG1 and Breast Neoplasms
 Tetralogy of Fallot Antibodies  >17 publications with JAG1 and Tetralogy of Fallot
 Bone Diseases Antibodies  >15 publications with JAG1 and Bone Diseases
 Eye Abnormalities Antibodies  >15 publications with JAG1 and Eye Abnormalities
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >50 publications with JAG1 and Blood
 Embryonic Tissue Antibodies  >30 publications with JAG1 and Embryonic Tissue
 Brain Antibodies  >30 publications with JAG1 and Brain
 Kidney Antibodies  >19 publications with JAG1 and Kidney
 Lung Antibodies  >10 publications with JAG1 and Lung
 Placenta Antibodies  >8 publications with JAG1 and Placenta
 Pancreas Antibodies  >8 publications with JAG1 and Pancreas
 Connective Tissue Antibodies  >7 publications with JAG1 and Connective Tissue
 Uterus Antibodies  >5 publications with JAG1 and Uterus
 Intestine Antibodies  >5 publications with JAG1 and Intestine
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