NP_000205.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
116,579 Da
NCBI Official Full Name
protein jagged-1
NCBI Official Synonym Full Names
jagged 1
NCBI Official Synonym Symbols
AGS; AHD; AWS; HJ1; CD339; JAGL1 [Similar Products]
NCBI Protein Information
protein jagged-1
UniProt Protein Name
Protein jagged-1
UniProt Synonym Protein Names
CD_antigen: CD339
UniProt Synonym Gene Names
UniProt Entry Name
JAG1_HUMAN
NCBI Summary for JAG1
The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008]
UniProt Comments for JAG1
JAG1: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Interacts with NOTCH2 and NOTCH3. Interacts with NOTCH1 (in the presence of calcium ions). Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 20p12.1-p11.23
Cellular Component: adherens junction; apical plasma membrane; extracellular region; integral to plasma membrane; membrane; plasma membrane
Molecular Function: calcium ion binding; growth factor activity; Notch binding; protein binding; structural molecule activity
Biological Process: angiogenesis; auditory receptor cell differentiation; blood vessel remodeling; cell fate determination; endothelial cell differentiation; hemopoiesis; keratinocyte differentiation; morphogenesis of an epithelial sheet; myoblast differentiation; negative regulation of fat cell differentiation; negative regulation of neuron differentiation; nervous system development; Notch receptor processing; Notch signaling pathway; positive regulation of myeloid cell differentiation; positive regulation of Notch signaling pathway; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of cell migration; regulation of cell proliferation; response to muramyl dipeptide; T cell mediated immunity
Disease: Alagille Syndrome 1; Tetralogy Of Fallot
Research Articles on JAG1
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Pathways associated with anti-JAG1 antibody
Diseases associated with anti-JAG1 antibody
Organs/Tissues associated with anti-JAG1 antibody
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