View our list of available Coronavirus (COVID-19, SARS-CoV-2, 2019-nCOV) antibodies, recombinant proteins, ELISA Kits... Options Full Datasheet Printer Friendly Datasheet Prepare for Printing Full Datasheet Printer Friendly Datasheet Prepare for Printing Have Questions? Ask Us! Request A Quote Today! Add To Compare List anti-JAG1 antibody :: Rabbit anti-Mouse JAG1 Polyclonal Antibody Catalog # MBS9132586 (SPECIAL PROMOTION: Get FREE $5 Amazon gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment) Unit / Price 0.02 mL / $210 +1 FREE 8GB USB 0.05 mL / $265 +1 FREE 8GB USB 0.1 mL / $355 +1 FREE 8GB USB 0.2 mL / $555 +1 FREE 8GB USB 5x0.2 mL / $2,275 +2 FREE 8GB USB Product Name Product Info Accession #s Product Desc Diseases/Tissues/Pathways Applications References Product Name JAG1, Polyclonal Antibody Popular Item Full Product Name JAG1 Polyclonal Antibody Product Synonym Names AGS; AGS1; AHD; AWS; CD339; HJ1; JAGL1 Product Gene Name anti-JAG1 antibody[Similar Products] Research Use Only For Research Use Only. Not for use in diagnostic procedures. TOP OMIM AF003837 mRNA 3D Structure ModBase 3D Structure for P78504 Clonality Polyclonal Isotype IgG Host Rabbit Species Reactivity Mouse Purity/Purification Affinity Purification Immunogen Recombinant protein of human JAG1 Storage Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Preparation and Storage Store at -20 degree C. Avoid freeze/thaw cycles. ISO Certification Manufactured in an ISO 9001:2015 Certified Laboratory. Other Notes Small volumes of anti-JAG1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply. TOP Related Product Information for anti-JAG1 antibody The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. Product Categories/Family for anti-JAG1 antibody Primary antibody Applications Tested/Suitable for anti-JAG1 antibody Western Blot (WB) Application Notes for anti-JAG1 antibody WB: 1:500 - 1:2000 Western Blot (WB) of anti-JAG1 antibody Western blot analysis of extracts of mouse brain, using JAG1 antibody at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.Lysates/proteins: 25ug per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit.Exposure time: 90s. TOP NCBI/Uniprot data below describe general gene information for JAG1. It may not necessarily be applicable to this product. NCBI GI # 20455033 NCBI GeneID 182 NCBI Accession # P78504.3 [Other Products] UniProt Primary Accession # P78504 [Other Products] UniProt Secondary Accession # O14902; O15122; Q15816; A0AV43; B4DYR1; E9PCF9[Other Products] UniProt Related Accession # P78504[Other Products] Molecular Weight 134kDa TOP NCBI Official Full Name Protein jagged-1 NCBI Official Synonym Full Names jagged 1 NCBI Official Symbol JAG1 [Similar Products] NCBI Official Synonym Symbols AGS; AHD; AWS; HJ1; AGS1; CD339; JAGL1 [Similar Products] NCBI Protein Information protein jagged-1 UniProt Protein Name Protein jagged-1 UniProt Synonym Protein Names CD_antigen: CD339 Protein Family Protein jagged UniProt Gene Name JAG1 [Similar Products] UniProt Synonym Gene Names JAGL1; Jagged1; hJ1 [Similar Products] TOP NCBI Summary for JAG1 The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008] TOP UniProt Comments for JAG1 JAG1: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Interacts with NOTCH2 and NOTCH3. Interacts with NOTCH1 (in the presence of calcium ions). Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 20p12.2Cellular Component: adherens junction; apical plasma membrane; membrane; plasma membraneMolecular Function: Notch binding; phospholipid binding; protein bindingBiological Process: Notch receptor processing; Notch signaling pathway; positive regulation of Notch signaling pathway; positive regulation of transcription from RNA polymerase II promoter; T cell mediated immunityDisease: Alagille Syndrome 1; Tetralogy Of Fallot Research Articles on JAG1 1. Our data revealed that MALAT1 inhibited tongue cancer cell growth and metastasis through miR-124-dependent JAG1 regulation. In conclusion, we revealed that MALAT1 may play an oncogenic role by increasing proliferation and metastasis of tongue cancer and is a potential therapeutic target in human tongue cancer. 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TOP Pathways associated with anti-JAG1 antibody Products by Pathway Pathway Diagram Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway antibodies Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway Diagram Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway antibodies Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway Diagram Delta-Notch Signaling Pathway antibodies Delta-Notch Signaling Pathway Diagram Disease Pathway antibodies Disease Pathway Diagram Diseases Of Signal Transduction Pathway antibodies Diseases Of Signal Transduction Pathway Diagram NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway antibodies NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway Diagram Notch Signaling Pathway antibodies Notch Signaling Pathway Diagram Diseases associated with anti-JAG1 antibody Disease Name Pubmed Publications Alagille Syndrome Antibodies >140 publications with JAG1 and Alagille Syndrome Liver Diseases Antibodies >124 publications with JAG1 and Liver Diseases Heart Defects, Congenital Antibodies >119 publications with JAG1 and Heart Defects, Congenital Heart Diseases Antibodies >36 publications with JAG1 and Heart Diseases Facies Antibodies >36 publications with JAG1 and Facies Breast Neoplasms Antibodies >27 publications with JAG1 and Breast Neoplasms Bone Diseases Antibodies >22 publications with JAG1 and Bone Diseases Chromosome Aberrations Antibodies >20 publications with JAG1 and Chromosome Aberrations Brain Diseases Antibodies >18 publications with JAG1 and Brain Diseases Tetralogy of Fallot Antibodies >18 publications with JAG1 and Tetralogy of Fallot Organs/Tissues associated with anti-JAG1 antibody Organ/Tissue Name Pubmed Publications Blood Antibodies >67 publications with JAG1 and Blood Embryonic Tissue Antibodies >38 publications with JAG1 and Embryonic Tissue Brain Antibodies >37 publications with JAG1 and Brain Kidney Antibodies >24 publications with JAG1 and Kidney Lung Antibodies >17 publications with JAG1 and Lung Connective Tissue Antibodies >11 publications with JAG1 and Connective Tissue Placenta Antibodies >9 publications with JAG1 and Placenta Pancreas Antibodies >9 publications with JAG1 and Pancreas Prostate Antibodies >7 publications with JAG1 and Prostate Intestine Antibodies >7 publications with JAG1 and Intestine TOP © 2006-24 MyBioSource.com. 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