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anti-KDM5B antibody :: Rabbit JARID1B Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS618499 anti-KDM5B antibody
Unit / Price
0.02 mL  /  $385 +1 FREE 8GB USB
0.1 mL  /  $540 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

JARID1B (KDM5B), Polyclonal Antibody

 Also Known As   

JARID1B

 Product Synonym Names    Anti -JARID1B
 Product Gene Name   

anti-KDM5B antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 1; NC_000001.10 (202696532..202777549, complement). Location: 1q32.1
 3D Structure    ModBase 3D Structure for O94800
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Monkey
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 Specificity    Recognizes endogenous levels of human JARID1B protein. The antibody does not cross-react with other JARID proteins, including JARID1A, JARID1C and JARID1D. Species Crossreactivity: monkey.
 Purity/Purification    Affinity Purified
Purified by protein A and peptide affinity chromatography.
 Form/Format    Supplied as a liquid in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100ug/ml BSA and 50% glycerol
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 Immunogen    Synthetic peptide (KLH- coupled) corresponding to the human JARID1B protein.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-KDM5B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-KDM5B antibody

   The methylation state of lysine residues in histone proteins is a major determinant for formation of active and inactive regions of the genome and is crucial for proper programming of the genome during development (1,2). Jumonji C (JmjC) domain-containing proteins represent the largest class of potential histone demethylase proteins (3). The JmjC domain can catalyze the demethylation of mono-, di-, and tri-methyl lysine residues via an oxidative reaction that requires iron and alpha-ketoglutarate (3). Based on homology, both humans and mice contain at least 30 such proteins, which can be divided into 7 separate families (3). The JARID (Jumonji/AT-rich interactive domain-containing protein) family contains four members: JARID1A (also RBP2 and RBBP2), JARID1B (also PLU-1), JARID1C (also SMCX) and JARID1D (also SMCY) (4). In addition to the JmJC domain, these proteins contain JmJN, BRIGHT, C5HC2 zinc-finger, and PHD domains, the latter of which binds to methylated histone H3 (Lys9) (4).

All four JARID proteins demethylate di- and tri-methyl histone H3 Lys4; JARID1B also demethylates mono-methyl histone H3 Lys4 (5-7). JARID1A is a critical RB-interacting protein and is required for Polycomb- Repressive Complex 2 (PRC2)-mediated transcriptional repression during ES cell differentiation (8). A JARID1A-NUP98 gene fusion is associated with myeloid leukemia (9). JARID1B, which interacts with many proteins including c-Myc and HDAC4, may play a role in cell fate decisions by blocking terminal differentiation (10-12). JARID1B is over-expressed in many breast cancers and may act by repressing multiple tumor suppressor genes including BRCA1 and HOXA5 (13,14). JARID1C has been found in a complex with HDAC1, HDAC2, G9a and REST, which binds to and represses REST target genes in non-neuronal cells (7). JARID1C mutations are associated with X-linked mental retardation and epilepsy (15,16). JARID1D is largely uncharacterized.
 Product Categories/Family for anti-KDM5B antibody    Antibodies; Abs to Enzymes
 Applications Tested/Suitable for anti-KDM5B antibody   

Western Blot (WB), Immunoprecipitation (IP)

 Application Notes for anti-KDM5B antibody    Suitable for use in Western Bot and Immunoprecipitation.
Dilution: Western blot: 1:1000
Immunoprecipitation 1:25
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NCBI/Uniprot data below describe general gene information for KDM5B. It may not necessarily be applicable to this product.
 NCBI GI #    119611841
 NCBI GeneID    10765
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 UniProt Primary Accession #    O94800 [Other Products]
 UniProt Related Accession #    O94800; Q6UGB8; Q9NSZ7; Q9UFC7; Q9UFD3; Q9UGL1; Q9UIW7 [Other Products]
 Molecular Weight    48,638 Da [Similar Products]
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 NCBI Official Full Name    Jumonji, AT rich interactive domain 1B (RBP2-like), isoform CRA_d
 NCBI Official Synonym Full Names    lysine (K)-specific demethylase 5B
 NCBI Official Symbol    KDM5B [Similar Products]
 NCBI Official Synonym Symbols   
CT31; PLU1; PUT1; PLU-1; JARID1B; FLJ10538; FLJ12459; FLJ12491; FLJ16281; FLJ23670; RBBP2H1A
[Similar Products]
 NCBI Protein Information    lysine-specific demethylase 5B; RBP2-H1; OTTHUMP00000038815; OTTHUMP00000038816; OTTHUMP00000197658; cancer/testis antigen 31; histone demethylase JARID1B; putative DNA/chromatin binding motif; jumonji, AT rich interactive domain 1B; jumonji/ARID domain-containing protein 1B; retinoblastoma-binding protein 2 homolog 1; retinoblastoma-binding protein 2, homolog 1A
 UniProt Protein Name    HRIHFB2060 protein
 Protein Family    Lysine-specific demethylase
 UniProt Gene Name    HRIHFB2060 [Similar Products]
 UniProt Entry Name    O94800_HUMAN
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 UniProt Comments for KDM5B    JARID1B: Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma. Interacts with FOXG1B, PAX9, MYC, MYCN and RB1. Interacts with HDAC1, HDAC4, HDAC5 and HDAC7. Ubiquitously expressed, with highest levels in testis. Down-regulated in melanoma and glioblastoma. Up-regulated in breast cancer. Belongs to the JARID1 histone demethylase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.14.11.-; Demethylase; Transcription, coactivator/corepressor; Oxidoreductase; Cancer Testis Antigen (CTA)

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: nucleoplasm; cytoplasm; nucleus

Molecular Function: protein binding; DNA binding; zinc ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; transcription factor activity; transcription corepressor activity

Biological Process: establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; rhythmic process; negative regulation of transcription, DNA-dependent
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 Research Articles on KDM5B    1. there is a significant increase in the percentage of circulating CD8+ T cells that are specific for two of three investigated JARID1B HLA-A*0201 peptides
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KDM5B antibodyDiseases associated with anti-KDM5B antibody
 Reference Product  PubMed Publications
 PAX9 antibody  >3 publications with KDM5B and PAX9
 FOXG1 antibody  >1 publications with KDM5B and FOXG1
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >19 publications with KDM5B and Neoplasms
 Breast Neoplasms Antibodies  >9 publications with KDM5B and Breast Neoplasms
 Melanoma Antibodies  >7 publications with KDM5B and Melanoma
 Mammary Neoplasms, Animal Antibodies  >3 publications with KDM5B and Mammary Neoplasms, Animal
 Skin Neoplasms Antibodies  >2 publications with KDM5B and Skin Neoplasms
 Neoplasm Metastasis Antibodies  >2 publications with KDM5B and Neoplasm Metastasis
 Lung Diseases Antibodies  >2 publications with KDM5B and Lung Diseases
 Carcinoma, Ductal, Breast Antibodies  >1 publications with KDM5B and Carcinoma, Ductal, Breast
 Prostatic Diseases Antibodies  >1 publications with KDM5B and Prostatic Diseases
 Genetic Diseases, Inborn Antibodies  >1 publications with KDM5B and Genetic Diseases, Inborn
Organs/Tissues associated with anti-KDM5B antibody
 Organ/Tissue Name  Pubmed Publications
 Mammary Gland Antibodies  >6 publications with KDM5B and Mammary Gland
 Testis Antibodies  >5 publications with KDM5B and Testis
 Brain Antibodies  >3 publications with KDM5B and Brain
 Lung Antibodies  >2 publications with KDM5B and Lung
 Embryonic Tissue Antibodies  >2 publications with KDM5B and Embryonic Tissue
 Bone Antibodies  >2 publications with KDM5B and Bone
 Blood Antibodies  >2 publications with KDM5B and Blood
 Skin Antibodies  >2 publications with KDM5B and Skin
 Kidney Antibodies  >1 publications with KDM5B and Kidney
 Prostate Antibodies  >1 publications with KDM5B and Prostate
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