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anti-MAPK8IP3 antibody :: Rabbit JIP3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS820556
Unit / Price
0.03 mL  /  $155 +1 FREE 8GB USB
0.1 mL  /  $220 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

JIP3 (MAPK8IP3), Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-JIP3 Antibody

 Product Synonym Names    JIP3; KIAA1066; C-Jun-amino-terminal kinase-interacting protein 3; JIP-3; JNK-interacting protein 3; JNK MAP kinase scaffold protein 3; Mitogen-activated protein kinase 8-interacting protein 3
 Product Gene Name   

anti-MAPK8IP3 antibody

[Similar Products]
 Antibody/Peptide Pairs    JIP3 peptide (MBS823918) is used for blocking the activity of JIP3 antibody (MBS820556)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605431
 3D Structure    ModBase 3D Structure for Q9UPT6
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat, Bovine
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 Specificity    Recognizes endogenous levels of JIP3 protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
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 Entrez Gene    23162 (Human); 30954 (Mouse)
 SwissProt    Q9UPT6 (Human); Q9ESN9 (Mouse)
 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence within the center region of human JIP3. The exact sequence is proprietary.
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-MAPK8IP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-MAPK8IP3 antibody

   Rabbit polyclonal antibody to JIP3
 Applications Tested/Suitable for anti-MAPK8IP3 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

 Application Notes for anti-MAPK8IP3 antibody    WB (1/500 - 1/1000), IH (1/100 - 1/200), IF/ICC (1/100 - 1/500)
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 Western Blot (WB) of anti-MAPK8IP3 antibody    anti-MAPK8IP3 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-MAPK8IP3 antibody    Immunohistochemical analysis of JIP3 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.
anti-MAPK8IP3 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence/Immunocytochemistry (IF/ICC) of anti-MAPK8IP3 antibody    Immunofluorescent analysis of JIP3 staining in PC12 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 degree C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue).
anti-MAPK8IP3 antibody Immunofluorescence/Immunocytochemistry (IF/ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for MAPK8IP3. It may not necessarily be applicable to this product.
 NCBI GI #    94557295
 NCBI GeneID    23162
 NCBI Accession #    NP_001035529.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001040439.1 [Other Products]
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 UniProt Primary Accession #    Q9UPT6 [Other Products]
 UniProt Secondary Accession #    Q96RY4; Q9H4I4; Q9H7P1; Q9NUG0; A2A2B3; A7E2B3 [Other Products]
 UniProt Related Accession #    Q9UPT6 [Other Products]
 Molecular Weight    29,052 Da
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 NCBI Official Full Name    C-Jun-amino-terminal kinase-interacting protein 3 isoform 2
 NCBI Official Synonym Full Names    mitogen-activated protein kinase 8 interacting protein 3
 NCBI Official Symbol    MAPK8IP3 [Similar Products]
 NCBI Official Synonym Symbols   
syd; JIP3; SYD2; JSAP1
[Similar Products]
 NCBI Protein Information    C-Jun-amino-terminal kinase-interacting protein 3; JIP-3; JNK-interacting protein 3; JNK/SAPK-associated protein-1; JNK MAP kinase scaffold protein 3; homolog of Drosophila Sunday driver 2; C-jun-amino-terminal kinase interacting protein 3; JNK/stress-activated protein kinase-associated protein 1; mitogen-activated protein kinase 8-interacting protein 3
 UniProt Protein Name    C-Jun-amino-terminal kinase-interacting protein 3
 UniProt Synonym Protein Names   
JNK MAP kinase scaffold protein 3; Mitogen-activated protein kinase 8-interacting protein 3
 Protein Family    C-Jun-amino-terminal kinase-interacting protein
 UniProt Gene Name    MAPK8IP3 [Similar Products]
 UniProt Synonym Gene Names    JIP3; KIAA1066; JIP-3; JNK-interacting protein 3 [Similar Products]
 UniProt Entry Name    JIP3_HUMAN
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 NCBI Summary for MAPK8IP3    The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
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 UniProt Comments for MAPK8IP3    JIP3: a member of the JNK-interacting protein group of scaffold proteins that selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies in the mouse suggested that this protein may interact with and regulate the activity of numerous protein kinases of the JNK signaling pathway. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined.

Protein type: Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: Golgi membrane; smooth endoplasmic reticulum; dendrite; cytoplasm; axolemma

Molecular Function: JUN kinase binding; MAP-kinase scaffold activity; receptor signaling complex scaffold activity; mitogen-activated protein kinase kinase binding; kinesin binding; mitogen-activated protein kinase kinase kinase binding

Biological Process: vesicle-mediated transport; axon guidance; protein localization; regulation of gene expression; in utero embryonic development; forebrain development; respiratory gaseous exchange; positive regulation of neuron differentiation; alveolus development; regulation of JNK cascade; activation of JNK activity; post-embryonic development
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 Research Articles on MAPK8IP3    1. The results of this study finding suggested that a model by which the self-assembly of SYD-2/Liprin-alpha proteins mediated by the coiled-coil LH1 domain is one of the key steps to the accumulation of presynaptic components at nascent synaptic junctions
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-MAPK8IP3 antibodyPathways associated with anti-MAPK8IP3 antibody
 Reference Product  PubMed Publications
 MAPK8 antibody  >4 publications with MAPK8IP3 and MAPK8
 ARF6 antibody  >3 publications with MAPK8IP3 and ARF6
 MAP3K1 antibody  >2 publications with MAPK8IP3 and MAP3K1
 SRC antibody  >2 publications with MAPK8IP3 and SRC
 MAP2K7 antibody  >1 publications with MAPK8IP3 and MAP2K7
 MAP2K4 antibody  >1 publications with MAPK8IP3 and MAP2K4
 Products by Pathway  Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram
 Signaling Events Mediated By Focal Adhesion Kinase Pathway antibodies  Signaling Events Mediated By Focal Adhesion Kinase Pathway Diagram
Diseases associated with anti-MAPK8IP3 antibodyOrgans/Tissues associated with anti-MAPK8IP3 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2 publications with MAPK8IP3 and Inflammation
 Nerve Degeneration Antibodies  >2 publications with MAPK8IP3 and Nerve Degeneration
 Heart Diseases Antibodies  >1 publications with MAPK8IP3 and Heart Diseases
 Neural Tube Defects Antibodies  >1 publications with MAPK8IP3 and Neural Tube Defects
 Cognition Disorders Antibodies  >1 publications with MAPK8IP3 and Cognition Disorders
 Congenital Abnormalities Antibodies  >1 publications with MAPK8IP3 and Congenital Abnormalities
 Atherosclerosis Antibodies  >1 publications with MAPK8IP3 and Atherosclerosis
 Pregnancy Complications Antibodies  >1 publications with MAPK8IP3 and Pregnancy Complications
 Hyperplasia Antibodies  >1 publications with MAPK8IP3 and Hyperplasia
 Kidney Diseases Antibodies  >1 publications with MAPK8IP3 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >60 publications with MAPK8IP3 and Nerve
 Brain Antibodies  >18 publications with MAPK8IP3 and Brain
 Embryonic Tissue Antibodies  >10 publications with MAPK8IP3 and Embryonic Tissue
 Lung Antibodies  >4 publications with MAPK8IP3 and Lung
 Muscle Antibodies  >3 publications with MAPK8IP3 and Muscle
 Heart Antibodies  >3 publications with MAPK8IP3 and Heart
 Blood Antibodies  >2 publications with MAPK8IP3 and Blood
 Bone Antibodies  >2 publications with MAPK8IP3 and Bone
 Kidney Antibodies  >2 publications with MAPK8IP3 and Kidney
 Pancreas Antibodies  >1 publications with MAPK8IP3 and Pancreas
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