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anti-KDM6B antibody :: Rabbit anti-Human, Mouse JMJD3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS647954 anti-KDM6B antibody
Unit / Price
0.2 mL  /  $550 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

JMJD3 (KDM6B), Polyclonal Antibody

 Also Known As   

JMJD3, ID (Kdm6b, Jmjd3, Kiaa0346, Lysine-specific demethylase 6B, JmjC domain-containing protein 3, Jumonji domain-containing protein 3)

 Product Synonym Names    Anti -JMJD3, ID (Kdm6b, Jmjd3, Kiaa0346, Lysine-specific demethylase 6B, JmjC domain-containing protein 3, Jumonji domain-containing protein 3)
 Product Gene Name   

anti-KDM6B antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 17; NC_000017.10 (7737521..7758118). Location: 17p13.1
 OMIM    611577
 3D Structure    ModBase 3D Structure for O15054
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    Human, mouse
 Purity/Purification    Affinity Purified
Purified by Protein G affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
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 Immunogen    Mouse JMJD3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 964~993 amino acids from the center region of mouse JMJD3.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-KDM6B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-KDM6B antibody

   Covalent modification of histones plays critical role in regulating chromatin structure and transcription. While most covalent histone modifications are reversible, only recently has it been established that methyl groups are subject to enzymatic removal from histones. A family of novel JmjC domain-containing histone demethylation (JHDM) enzymes have been identified that perform this specific function. Histone demethylation by JHDM proteins requires cofactors Fe(II) and alpha-ketoglutarate. Family members include JHDM1 (demethylating histone 3 at lysine 36), and JHDM2A as well as JMJD2CH3K9 (both of which demethylate histone 3 at lysine 9). Contributions of histone demethylase activity to tumor development, decreases in cell proliferation, and hormone-dependent transcriptional activation have been observed.
 Product Categories/Family for anti-KDM6B antibody    Antibodies; Abs to Enzymes
 Applications Tested/Suitable for anti-KDM6B antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-KDM6B antibody    Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:50-100
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NCBI/Uniprot data below describe general gene information for KDM6B. It may not necessarily be applicable to this product.
 NCBI GI #    14603031
 NCBI GeneID    23135
 NCBI Accession #    AAH09994.1 [Other Products]
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 UniProt Primary Accession #    O15054 [Other Products]
 UniProt Secondary Accession #    Q96G33; C9IZ40 [Other Products]
 UniProt Related Accession #    O15054 [Other Products]
 Molecular Weight    176,632 Da [Similar Products]
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 NCBI Official Full Name    JMJD3 protein
 NCBI Official Synonym Full Names    lysine (K)-specific demethylase 6B
 NCBI Official Symbol    KDM6B [Similar Products]
 NCBI Official Synonym Symbols   
JMJD3
[Similar Products]
 NCBI Protein Information    lysine-specific demethylase 6B; lysine demethylase 6B; jmjC domain-containing protein 3; jumonji domain-containing protein 3; jumonji domain containing 3, histone lysine demethylase
 UniProt Protein Name    Lysine-specific demethylase 6B
 UniProt Synonym Protein Names   
JmjC domain-containing protein 3; Jumonji domain-containing protein 3; Lysine demethylase 6B
 Protein Family    Lysine-specific demethylase
 UniProt Gene Name    KDM6B [Similar Products]
 UniProt Synonym Gene Names    JMJD3; KIAA0346 [Similar Products]
 UniProt Entry Name    KDM6B_HUMAN
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 UniProt Comments for KDM6B    Function: Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code. Demethylates trimethylated and dimethylated H3 'Lys-27'. Plays a central role in regulation of posterior development, by regulating HOX gene expression. Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. Ref.6 Ref.7

Cofactor: Ascorbate

By similarity. Ref.6Fe2+. Ref.6

Subunit structure: Interacts with TLE1

By similarity. Component of the MLL4 complex, at least composed of KMT2B/MLL4, ASH2L, RBBP5, WDR5, and KDM6B. Ref.6

Subcellular location: Nucleus

Probable Ref.6.

Induction: By 12-O-tetradecanoylphorbol-13-acetate (TPA) in myeloid leukemia cells. Ref.5

Sequence similarities: Belongs to the UTX family.Contains 1 JmjC domain.

Sequence caution: The sequence BAA21572.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
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 Research Articles on KDM6B    1. Data suggest that the suppression of different key inflammatory regulators through JMJD3-attenuation would evaluate potential therapeutic targets and to elucidate the molecular mechanism of JMJD3-knockdown (KD) dependent effects in THP-1 cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KDM6B antibodyDiseases associated with anti-KDM6B antibody
 Reference Product  PubMed Publications
 SMAD3 antibody  >3 publications with KDM6B and SMAD3
 TBX21 antibody  >3 publications with KDM6B and TBX21
 SMAD2 antibody  >2 publications with KDM6B and SMAD2
 SMAD4 antibody  >2 publications with KDM6B and SMAD4
 ASCL1 antibody  >2 publications with KDM6B and ASCL1
 SMAD1 antibody  >1 publications with KDM6B and SMAD1
 HOXB1 antibody  >1 publications with KDM6B and HOXB1
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >27 publications with KDM6B and Neoplasms
 Inflammation Antibodies  >9 publications with KDM6B and Inflammation
 Nervous System Diseases Antibodies  >7 publications with KDM6B and Nervous System Diseases
 Death Antibodies  >5 publications with KDM6B and Death
 Neural Tube Defects Antibodies  >5 publications with KDM6B and Neural Tube Defects
 Necrosis Antibodies  >4 publications with KDM6B and Necrosis
 Skin Diseases Antibodies  >4 publications with KDM6B and Skin Diseases
 Kidney Diseases Antibodies  >4 publications with KDM6B and Kidney Diseases
 Prostatic Diseases Antibodies  >3 publications with KDM6B and Prostatic Diseases
 Cell Transformation, Neoplastic Antibodies  >2 publications with KDM6B and Cell Transformation, Neoplastic
Organs/Tissues associated with anti-KDM6B antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >11 publications with KDM6B and Blood
 Embryonic Tissue Antibodies  >8 publications with KDM6B and Embryonic Tissue
 Bone Antibodies  >8 publications with KDM6B and Bone
 Skin Antibodies  >6 publications with KDM6B and Skin
 Brain Antibodies  >6 publications with KDM6B and Brain
 Prostate Antibodies  >4 publications with KDM6B and Prostate
 Kidney Antibodies  >4 publications with KDM6B and Kidney
 Heart Antibodies  >4 publications with KDM6B and Heart
 Lung Antibodies  >3 publications with KDM6B and Lung
 Pancreas Antibodies  >2 publications with KDM6B and Pancreas
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