Q8N371
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
jumonji domain containing 5
NCBI Official Synonym Full Names
jumonji domain containing 5
NCBI Official Synonym Symbols
NCBI Protein Information
lysine-specific demethylase 8; OTTHUMP00000162455; jmjC domain-containing protein 5; jumonji domain-containing protein 5
UniProt Protein Name
Lysine-specific demethylase 8
UniProt Synonym Protein Names
JmjC domain-containing protein 5; Jumonji domain-containing protein 5
UniProt Synonym Gene Names
UniProt Entry Name
KDM8_HUMAN
NCBI Summary for JMJD5
This gene likely encodes a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential role for this protein as a tumor suppressor. Alternatively spliced transcript variants have been described.
UniProt Comments for JMJD5
JMJD5: Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1), leading to regulate cancer cell proliferation. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 1.14.11.27; Cell cycle regulation; Demethylase
Chromosomal Location of Human Ortholog: 16p12.1
Cellular Component: nucleus
Molecular Function: histone demethylase activity (H3-K36 specific); metal ion binding; chromatin binding
Biological Process: transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; G2/M transition of mitotic cell cycle
Research Articles on JMJD5
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Diseases associated with anti-JMJD5 antibody
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