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anti-JPH4 antibody :: Rabbit JPH2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS150182
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

JPH2 (JPH4), Polyclonal Antibody

 Also Known As   

JPH2 Antibody

 Product Synonym Names    JPH2; JP4; JPHL1; KIAA1831; Junctophilin-4; Junctophilin-like 1 protein; JP-4; junctophilin 4
 Product Gene Name   

anti-JPH4 antibody

[Similar Products]
 Antibody/Peptide Pairs    JPH2 peptide (MBS153032) is used for blocking the activity of JPH2 antibody (MBS150182)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 613873
 3D Structure    ModBase 3D Structure for Q96JJ6
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    JPH2 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    JPH2 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human JPH2.
 Buffer    JPH2 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    JPH2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-JPH4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-JPH4 antibody

   JPH2 Antibody: Junctional complexes between the plasma membrane (PM) and endoplasmic/sarcoplasmic reticulum (ER/SR) are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. Junctophilins (JPs) are important components of the junctional complexes. JPs are composed of a carboxy-terminal hydrophobic segment spanning the ER/SR membrane and a remaining cytoplasmic domain that shows specific affinity for the PM. Four JPs have been identified as tissue-specific subtypes derived from different genes: JPH1 is expressed in skeletal muscle, JPH2 is detected throughout all muscle cell types, and JPH3 and JPH4 are predominantly expressed in the brain and contribute to the subsurface cistern formation in neurons. JPH2-null mice died of embryonic cardiac arrest and human patients with mutations in the JPH2 gene showed hypertrophic cardiomyopathy, demonstrating the importance of this protein. Multiple isoforms of JPH2 are known to exist.
 Applications Tested/Suitable for anti-JPH4 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-JPH4 antibody    JPH2 antibody can be used for detection of JPH2 by Western blot at 1 - 2 mug/mL. Antibody can also be used for immunohistochemistry starting at 2.5 mug/mL.
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 Western Blot (WB) of anti-JPH4 antibody    Western blot analysis of JPH2 in mouse brain tissue lysate with JPH2 antibody at (A) 1 and (B) 2 μg/mL.
anti-JPH4 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-JPH4 antibody    Immunohistochemistry of JPH2 in mouse skeletal muscle tissue with JPH2 antibody at 2.5 μg/mL.
anti-JPH4 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for JPH4. It may not necessarily be applicable to this product.
 NCBI GI #    21704281
 NCBI GeneID    57158
 NCBI Accession #    NP_065166 [Other Products]
 NCBI GenBank Nucleotide #    NM_020433.4 [Other Products]
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 UniProt Primary Accession #    Q96JJ6 [Other Products]
 UniProt Secondary Accession #    O95913; Q5JY74; Q9UJN4; E1P5X1 [Other Products]
 UniProt Related Accession #    Q9BR39 [Other Products]
 Molecular Weight    13,951 Da
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 NCBI Official Full Name    junctophilin-2 isoform 1
 NCBI Official Synonym Full Names    junctophilin 2
 NCBI Official Symbol    JPH2 [Similar Products]
 NCBI Official Synonym Symbols   
JP2; JP-2; CMH17
[Similar Products]
 NCBI Protein Information    junctophilin-2; junctophilin type 2
 UniProt Protein Name    Junctophilin-2
 UniProt Synonym Protein Names   
Junctophilin type 2
 Protein Family    Junctophilin
 UniProt Gene Name    JPH2 [Similar Products]
 UniProt Synonym Gene Names    JP2; JP-2 [Similar Products]
 UniProt Entry Name    JPH2_HUMAN
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 NCBI Summary for JPH4    Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family. Alternative splicing has been observed at this locus and two variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2008]
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 UniProt Comments for JPH4    JPH4: Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain- specific and appears to have an active role in certain neurons involved in motor coordination and memory. Belongs to the junctophilin family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 14q11

Cellular Component: smooth endoplasmic reticulum; integral to membrane; plasma membrane; dendritic shaft

Biological Process: regulation of synaptic plasticity; learning; neuromuscular process controlling balance
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 Research Articles on JPH4    1. Our data identify a mechanistic link between microtubule densification and T-tubule remodeling and reveal microtubule-mediated JP2 redistribution as a novel mechanism for T-tubule disruption, loss of excitation-contraction coupling, and heart failure.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Diseases associated with anti-JPH4 antibodyOrgans/Tissues associated with anti-JPH4 antibody
 Disease Name  Pubmed Publications
 Disease Models, Animal Antibodies  >2 publications with JPH4 and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >11 publications with JPH4 and Muscle
 Connective Tissue Antibodies  >1 publications with JPH4 and Connective Tissue
 Embryonic Tissue Antibodies  >1 publications with JPH4 and Embryonic Tissue
 Lung Antibodies  >1 publications with JPH4 and Lung
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