NP_038850.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
protein jagged-1
NCBI Official Synonym Full Names
jagged 1
NCBI Protein Information
protein jagged-1
UniProt Protein Name
Protein jagged-1
UniProt Synonym Protein Names
CD_antigen: CD339
UniProt Synonym Gene Names
UniProt Entry Name
JAG1_MOUSE
UniProt Comments for Jag1
JAG1: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Interacts with NOTCH2 and NOTCH3. Interacts with NOTCH1 (in the presence of calcium ions). Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.
Protein type: Membrane protein, integral
Cellular Component: membrane; apical part of cell; plasma membrane; integral to membrane
Molecular Function: protein binding; calcium ion binding; Notch binding
Biological Process: Notch signaling pathway; camera-type eye development; positive regulation of myeloid cell differentiation; T cell mediated immunity; multicellular organismal development; auditory receptor cell differentiation; negative regulation of fat cell differentiation; regulation of cell proliferation; positive regulation of osteoblast differentiation; negative regulation of neuron differentiation; negative regulation of cell differentiation; organ morphogenesis; response to muramyl dipeptide; morphogenesis of an epithelial sheet; positive regulation of transcription from RNA polymerase II promoter; blood vessel remodeling; cell communication; inner ear development; positive regulation of Notch signaling pathway
Product References and Citations for anti-Jag1 antibody
Shimizu K.,et al.J. Biol. Chem. 274:32961-32969(1999). Loomes K.M.,et al.Hum. Mol. Genet. 8:2443-2449(1999).
Research Articles on Jag1
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Products associated with anti-Jag1 antibody
Pathways associated with anti-Jag1 antibody
Diseases associated with anti-Jag1 antibody
Organs/Tissues associated with anti-Jag1 antibody
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