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anti-CDH6 antibody :: Rabbit anti-Human K Cadherin (CDH6) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9203941
Unit / Price
0.08 mL  /  $150 +1 FREE 8GB USB
0.4 mL  /  $340 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

K Cadherin (CDH6), Polyclonal Antibody

 Also Known As   

K Cadherin (CDH6) Antibody (C-term)

 Product Synonym Names    Cadherin-6; Kidney cadherin; K-cadherin; CDH6
 Product Gene Name   

anti-CDH6 antibody

[Similar Products]
 Antibody/Peptide Pairs    K Cadherin (CDH6) peptide (MBS9220519) is used for blocking the activity of K Cadherin (CDH6) antibody (MBS9203941)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence Positions    665-695
 OMIM    603007
 3D Structure    ModBase 3D Structure for P55285
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 Clonality    Polyclonal
 Isotype    Rabbit Ig
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    This K Cadherin (CDH6) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 665-695 amino acids from the C-terminal region of human K Cadherin (CDH6).
 Purity/Purification    Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
 Form/Format    Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
 Concentration    Vial Concentration: 0.48 (lot specific)
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 Antigen Type    Synthetic Peptide
 Antigen Source    HUMAN
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 Preparation and Storage    Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C in small aliquots to prevent freeze-thaw cycles.
 Other Notes    Small volumes of anti-CDH6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-CDH6 antibody

   CDH6 is a type II classical cadherin from the cadherin superfamily. It is a calcium dependent cell-cell adhesion membrane glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Cadherins mediate cell-cell binding in a homophilic manner, contributing to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. Strong transcriptional expression of the CDH6 gene has been observed in hepatocellular and renal carcinoma cell lines, suggesting a possible role in metastasis and invasion.
 Product Categories/Family for anti-CDH6 antibody    Cancer; Signal Transduction
 Applications Tested/Suitable for anti-CDH6 antibody   

Flow Cytometry (FC/FACS), ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-CDH6 antibody    WB~~1:1000
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 Western Blot (WB) of anti-CDH6 antibody    Western blot analysis of anti-DH6 Antibody (C-term) (RB14082) in 293 cell line lysates (35ug/lane). DH6(arrow) was detected using the purified Pab.
anti-CDH6 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-CDH6 antibody    Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with CDH6 antibody (C-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
anti-CDH6 antibody Immunohistochemistry (IHC) (IHC) image
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 Flow Cytometry (FC/FACS) of anti-CDH6 antibody    Flow cytometric analysis of NCI-H292 cells using CDH6 Antibody (C-term)(bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
anti-CDH6 antibody Flow Cytometry (FC/FACS) (FC/FACS) image
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NCBI/Uniprot data below describe general gene information for CDH6. It may not necessarily be applicable to this product.
 NCBI GI #    4826673
 NCBI GeneID    1004
 NCBI Accession #    NP_004923.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_004932.3 [Other Products]
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 UniProt Primary Accession #    P55285 [Other Products]
 UniProt Secondary Accession #    Q9BWS0; A8K5H5 [Other Products]
 UniProt Related Accession #    P55285 [Other Products]
 Molecular Weight    88309
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 NCBI Official Full Name    cadherin-6 preproprotein
 NCBI Official Synonym Full Names    cadherin 6, type 2, K-cadherin (fetal kidney)
 NCBI Official Symbol    CDH6 [Similar Products]
 NCBI Official Synonym Symbols   
CAD6; KCAD
[Similar Products]
 NCBI Protein Information    cadherin-6
 UniProt Protein Name    Cadherin-6
 UniProt Synonym Protein Names   
Kidney cadherin; K-cadherin
 Protein Family    Cadherin
 UniProt Gene Name    CDH6 [Similar Products]
 UniProt Synonym Gene Names    K-cadherin [Similar Products]
 UniProt Entry Name    CADH6_HUMAN
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 NCBI Summary for CDH6    This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis. [provided by RefSeq, May 2011]
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 UniProt Comments for CDH6    CDH6: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Highly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a weak expression. Also expressed in certain liver and kidney carcinomas. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 5p13.3

Cellular Component: integral to membrane; plasma membrane

Molecular Function: calcium ion binding

Biological Process: intercellular junction assembly and maintenance; homophilic cell adhesion; cell adhesion
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Product References and Citations for anti-CDH6 antibody

   Liu,T., J. Proteome Res. 4 (6), 2070-2080 (2005)
Shimoyama,Y., Biochem. J. 349 (PT 1), 159-167 (2000)
Shimoyama,Y., J. Biol. Chem. 274 (17), 11987-11994 (1999)
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 Research Articles on CDH6    1. CDH6 is under the control of the transcription factor RUNX2, which we previously described as a crucial mediator of the Id1 pro-invasive function in thyroid tumor cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-CDH6 antibodyPathways associated with anti-CDH6 antibody
 Reference Product  PubMed Publications
 CDH4 antibody  >8 publications with CDH6 and CDH4
 CDH7 antibody  >6 publications with CDH6 and CDH7
 CDH9 antibody  >3 publications with CDH6 and CDH9
 CDH13 antibody  >2 publications with CDH6 and CDH13
 CDH10 antibody  >2 publications with CDH6 and CDH10
 CDH15 antibody  >1 publications with CDH6 and CDH15
 CDH18 antibody  >1 publications with CDH6 and CDH18
 Products by Pathway  Pathway Diagram
 Nucleotide Excision Repair Pathway antibodies  Nucleotide Excision Repair Pathway Diagram
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 Nucleotide Excision Repair Pathway antibodies  Nucleotide Excision Repair Pathway Diagram
 Nucleotide Excision Repair Pathway antibodies  Nucleotide Excision Repair Pathway Diagram
 Nucleotide Excision Repair Pathway antibodies  Nucleotide Excision Repair Pathway Diagram
Diseases associated with anti-CDH6 antibodyOrgans/Tissues associated with anti-CDH6 antibody
 Disease Name  Pubmed Publications
 Neoplasm Metastasis Antibodies  >2 publications with CDH6 and Neoplasm Metastasis
 Learning Disorders Antibodies  >2 publications with CDH6 and Learning Disorders
 Inflammation Antibodies  >2 publications with CDH6 and Inflammation
 Nervous System Malformations Antibodies  >2 publications with CDH6 and Nervous System Malformations
 Liver Neoplasms Antibodies  >2 publications with CDH6 and Liver Neoplasms
 Abnormalities, Multiple Antibodies  >2 publications with CDH6 and Abnormalities, Multiple
 Adenocarcinoma Antibodies  >2 publications with CDH6 and Adenocarcinoma
 Carcinoma, Hepatocellular Antibodies  >1 publications with CDH6 and Carcinoma, Hepatocellular
 Kidney Diseases Antibodies  >1 publications with CDH6 and Kidney Diseases
 Breast Neoplasms Antibodies  >1 publications with CDH6 and Breast Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >16 publications with CDH6 and Brain
 Eye Antibodies  >5 publications with CDH6 and Eye
 Embryonic Tissue Antibodies  >3 publications with CDH6 and Embryonic Tissue
 Prostate Antibodies  >2 publications with CDH6 and Prostate
 Lung Antibodies  >2 publications with CDH6 and Lung
 Kidney Antibodies  >2 publications with CDH6 and Kidney
 Skin Antibodies  >1 publications with CDH6 and Skin
 Muscle Antibodies  >1 publications with CDH6 and Muscle
 Testis Antibodies  >1 publications with CDH6 and Testis
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