AAH82581.1
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
K(lysine) acetyltransferase 2B
NCBI Official Synonym Full Names
K(lysine) acetyltransferase 2B
NCBI Official Synonym Symbols
Pcaf; p/CAF; AI461839; AW536563; A930006P13Rik [Similar Products]
NCBI Protein Information
histone acetyltransferase KAT2B; histone acetylase PCAF; p300/CBP-associated factor; lysine acetyltransferase 2B; histone acetyltransferase PCAF
UniProt Protein Name
Histone acetyltransferase KAT2B
UniProt Synonym Protein Names
Histone acetyltransferase PCAF; Histone acetylase PCAF; Lysine acetyltransferase 2B; P300/CBP-associated factor; P/CAF
UniProt Synonym Gene Names
UniProt Entry Name
KAT2B_MOUSE
UniProt Comments for Kat2b
PCAF: Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Interacts with SIRT1. Interacts (unsumoylated form) with NR2C1; the interaction promotes transactivation activity. Interacts with EP300, CREBBP and DDX17. Interacts with NCOA1 and NCOA3. Component of a large chromatin remodeling complex, at least composed of MYSM1, KAT2B/PCAF, RBM10 and KIF11/TRIP5. Interacts with NR2C2 (hypophosphorylated and unsumoylated form); the interaction promotes the transactivation activity of NR2C2. Binds to HTLV-1 Tax. Interacts with and acetylates HIV-1 Tat. Interacts with KLF1; the interaction does not acetylate KLF1 and there is no enhancement of its transactivational activity. Interacts with NFE4. Interacts with MECOM. Interacts with E2F1; the interaction acetylates E2F1 augmenting its DNA-binding and transcriptional activity. Ubiquitously expressed but most abundant in heart and skeletal muscle. Belongs to the GCN5 family.
Protein type: EC 2.3.1.48; Acetyltransferase; Nuclear receptor co-regulator
Cellular Component: kinetochore; I band; nuclear chromatin; actomyosin; cytosol; nucleus; histone acetyltransferase complex; A band
Molecular Function: lysine N-acetyltransferase activity; cyclin-dependent protein kinase inhibitor activity; N-acetyltransferase activity; histone deacetylase binding; transcription coactivator activity; protein kinase binding; transcription factor binding; transferase activity; histone acetyltransferase binding; protein binding; histone acetyltransferase activity; acetyltransferase activity; transcription cofactor activity; transferase activity, transferring acyl groups; protein complex binding; chromatin binding
Biological Process: internal peptidyl-lysine acetylation; transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; negative regulation of cyclin-dependent protein kinase activity; rhythmic process; positive regulation of vasodilation; cell cycle; chromatin remodeling; negative regulation of cell proliferation; protein amino acid acetylation; regulation of transcription, DNA-dependent; cellular response to insulin stimulus; positive regulation of transcription from RNA polymerase II promoter; histone acetylation; peptidyl-lysine acetylation; N-terminal peptidyl-lysine acetylation
Research Articles on Kat2b
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Pathways associated with anti-Kat2b antibody
Diseases associated with anti-Kat2b antibody
Organs/Tissues associated with anti-Kat2b antibody
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