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anti-KALRN antibody :: Goat KALRN Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421796 anti-KALRN antibody
Unit / Price
0.1 mg  /  $225 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

KALRN, Polyclonal Antibody

 Also Known As   

Goat anti-KALRN Antibody

 Product Synonym Names    Goat Anti-Kalirin (isoform 2) Antibody; KALRN; kalirin, RhoGEF kinase; DUET; FLJ16443; HAPIP; TRAD; duo; huntingtin-associated protein interacting protein (duo); serine/threonine kinase with Dbl- and pleckstrin homology domains; KALRN antibody; kalirin; RhoGEF kinase antibody; DUET antibody; FLJ16443 antibody; HAPIP antibody; TRAD antibody; duo antibody; huntingtin-associated protein interacting protein (duo) antibody; serine/threonine kinase with Dbl- and pleckstrin homology domains antibody
 Product Gene Name   

anti-KALRN antibody

[Similar Products]
 Antibody/Peptide Pairs    KALRN peptide (MBS425417) is used for blocking the activity of KALRN antibody (MBS421796)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    DRGSFRNDGL KAS
 OMIM    604605
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Expected from sequence similarity: Human, Mouse, Rat, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence DRGSFRNDGLKAS-C, from the N Terminus of the protein sequence according to NP_001019831.2; NP_003938.1; NP_008995.2.
 Epitope    N Terminus
 Note    This antibody is expected to recognize reported isoforms NP_001019831.2 and NP_003938.1.
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-KALRN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-KALRN antibody   

Peptide ELISA (EIA)

 Application Notes for anti-KALRN antibody    Peptide ELISA: Antibody detection limit dilution 1: 64000.
Western Blot: Preliminary experiments gave an approx 49kDa band in Human, Mouse and Rat Brain lysates after 0.3ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 340kDa according to NP_001019831.2 and of 192kDa according to NP_003938.1. The 49kDa band was successfully blocked by incubation with the immunizing peptide.
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NCBI/Uniprot data below describe general gene information for KALRN. It may not necessarily be applicable to this product.
 NCBI GI #    148839466
 NCBI GeneID    8997
 NCBI Accession #    NP_001019831.2 [Other Products]
 NCBI Related Accession #    NP_003938.1; NP_008995.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_001024660.4 [Other Products]
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 UniProt Secondary Accession #    Q6ZN45; Q8TBQ5; Q9NSZ4; Q9Y2A5; A8MSI4; C9JQ37 [Other Products]
 UniProt Related Accession #    O60229 [Other Products]
 Molecular Weight    141,164 Da
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 NCBI Official Full Name    kalirin isoform 1
 NCBI Official Synonym Full Names    kalirin, RhoGEF kinase
 NCBI Official Symbol    KALRN [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    kalirin
 UniProt Protein Name    Kalirin
 UniProt Synonym Protein Names   
Huntingtin-associated protein-interacting protein; Protein Duo; Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain
 Protein Family    Kalirin
 UniProt Gene Name    KALRN [Similar Products]
 UniProt Synonym Gene Names    DUET; DUO; HAPIP; TRAD [Similar Products]
 UniProt Entry Name    KALRN_HUMAN
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 NCBI Summary for KALRN    Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking. [provided by RefSeq, Apr 2016]
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 UniProt Comments for KALRN    kalirin: a bifunctional enzyme with protein kinase activity and guanine-exchange factor (GEF) activity. A protein kinase of the CAMK group. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity. Genetic variants are associated with susceptibility to coronary heart disease type 5 (CHDS5), a multifactorial disease characterized by an imbalance between myocardial functional requirements and the capacity of the coronary vessels to supply sufficient blood flow. Interacts with the C-terminal of peptidylglycine alpha-amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1) Interacts with FASLG. The two GEF domains catalyze nucleotide exchange for RAC1 and RhoA which are bound by DH1 and DH2 respectively. The two GEF domains appear to play differing roles in neuronal development and axonal outgrowth. SH3 1 binds to the first GEF domain inhibiting GEF activity only when in the presence of a PXXP peptide, suggesting that the SH3 domain/peptide interaction mediates binding to GEF1. CRK1 SH3 domain binds to and inhibits GEF1 activity. 6 isoforms of the human protein are produced by alternative splicing. Isoform 2 is brain specific and is highly expressed in cerebral cortex, putamen, amygdala, hippocampus and caudate nucleus. Weakly expressed in brain stem and cerebellum. Isoform 4 is expressed in skeletal muscle.

Protein type: Protein kinase, CAMK; Kinase, protein; GEFs, Rac/Rho; GEFs; EC; Protein kinase, Ser/Thr (non-receptor); CAMK group; Trio family

Chromosomal Location of Human Ortholog: 3q21.2

Cellular Component: actin cytoskeleton; cytosol

Molecular Function: ATP binding; GTPase activator activity; guanyl-nucleotide exchange factor activity; metal ion binding; protein binding; protein serine/threonine kinase activity; Rho guanyl-nucleotide exchange factor activity

Biological Process: ephrin receptor signaling pathway; nervous system development; positive regulation of apoptosis; positive regulation of GTPase activity; protein amino acid phosphorylation; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; signal transduction; vesicle-mediated transport

Disease: Coronary Heart Disease, Susceptibility To, 5
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 Research Articles on KALRN    1. consider the GG genotype and the G allele of rs9289231 polymorphism of KALRN to be genetic risk factors for CAD in an Iranian population, especially in early-stage atherosclerotic vascular disease
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-KALRN antibodyDiseases associated with anti-KALRN antibody
 Products by Pathway  Pathway Diagram
 Arf6 Downstream Pathway antibodies  Arf6 Downstream Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies  Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 EPH-Ephrin Signaling Pathway antibodies  EPH-Ephrin Signaling Pathway Diagram
 EPHB Forward Signaling Pathway antibodies  EPHB Forward Signaling Pathway Diagram
 EPHB-mediated Forward Signaling Pathway antibodies  EPHB-mediated Forward Signaling Pathway Diagram
 G Alpha (12/13) Signalling Events Pathway antibodies  G Alpha (12/13) Signalling Events Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >13 publications with KALRN and Nervous System Diseases
 Cognition Disorders Antibodies  >5 publications with KALRN and Cognition Disorders
 Memory Disorders Antibodies  >4 publications with KALRN and Memory Disorders
 Learning Disorders Antibodies  >4 publications with KALRN and Learning Disorders
 Hypertension Antibodies  >2 publications with KALRN and Hypertension
 Dyslipidemias Antibodies  >2 publications with KALRN and Dyslipidemias
 Anxiety Disorders Antibodies  >1 publications with KALRN and Anxiety Disorders
 Lung Diseases Antibodies  >1 publications with KALRN and Lung Diseases
 Nerve Degeneration Antibodies  >1 publications with KALRN and Nerve Degeneration
 Hyperplasia Antibodies  >1 publications with KALRN and Hyperplasia
Organs/Tissues associated with anti-KALRN antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >28 publications with KALRN and Brain
 Nerve Antibodies  >5 publications with KALRN and Nerve
 Vascular Antibodies  >5 publications with KALRN and Vascular
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