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anti-KC antibody :: Rabbit KC Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS840366
Testing Data
Unit / Price
0.03 mg  /  $155 +1 FREE 8GB USB
0.1 mg  /  $355 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

KC, Polyclonal Antibody

 Also Known As   

KC Antibody

 Product Synonym Names    GRO alpha; GRO; chemokine (C-X-C); KC
 Product Gene Name   

anti-KC antibody

[Similar Products]
 Antibody/Peptide Pairs    KC peptide (MBS843592) is used for blocking the activity of KC antibody (MBS840366)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity purified
 Form/Format    100 ug (0.5mg/ml) affinity purified rabbit polyclonal antibody in phosphate-buffered saline (PBS) containing 30% glycerol, 0.5% BSA and 0.01% thimerosal.
Appearance: Colorless liquid
 Concentration    0.5 mg/ml (lot specific)
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 Immunogen    Synthetic peptide surrounding amino acid 78 of mouse KC
 Positive Control    Western Blot: Jurkat cell lysate and 3T3 cell lysate. IHC: Kidney tissue
 Handling    The antibody solution should be gently mixed before use.
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 Preparation and Storage    Store at -20 degree C. For long term storage, aliquot and freeze at - 70 degree C. Avoid repeated freeze/thaw cycles.
Shipping: Ships on cold packs.
 Other Notes    Small volumes of anti-KC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-KC antibody

   Background: KC, a homolog of human and hamster gro/MGSA, is a 72-amino acid CXC chemokine originally cloned from rat macrophages and lung tissue. It is the mediator for recruitment and activation of neutrophils in rat lung inflammation models. Expression of KC can be upregulated by LPS and IL-1-gamma stimulation. IFN-g blocks LPS-induced expression of KC.
 Applications Tested/Suitable for anti-KC antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-KC antibody    Western blotting (0.5-4 ug/ml) and Immunohistochemistry (5 ug/ml). However, the optimal concentrations should be determined individually. Blocking peptide is available separately.
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 Testing Data of anti-KC antibody    Western blot with KC Polyclonal Antibody
Lane 1: 80 ug Jurkat cell lysate
Lane 2: 80 ug 3T3 cell lysate
Blocking/Dilution buffer: 5% NFOM (1 hr at RT) / TBST Lox-1 Polyclonal Antibody used at 1:1000 dilution - O/N at 4 degree C.
Goat Anti-Rabbit IgG peroxidase conjugated used at 1:10,000 dilution - 1 hr at RT.
Predicted band size: -7.8 kDa.
Observed band size: -7.8 kDa.
anti-KC antibody Testing Data image
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NCBI/Uniprot data below describe general gene information for KC. It may not necessarily be applicable to this product.
 NCBI GI #    54887349
 NCBI GeneID    14825
 NCBI Accession #    AAH37997 [Other Products]
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 UniProt Related Accession #    P12850 [Other Products]
 Molecular Weight    10,254 Da
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 NCBI Official Full Name    Cxcl1 protein, partial
 NCBI Official Synonym Full Names    chemokine (C-X-C motif) ligand 1
 NCBI Official Symbol    Cxcl1 [Similar Products]
 NCBI Official Synonym Symbols   
KC; Fsp; N51; gro; Gro1; Mgsa; Scyb1
[Similar Products]
 NCBI Protein Information    growth-regulated alpha protein
 UniProt Protein Name    Growth-regulated alpha protein
 UniProt Synonym Protein Names   
C-X-C motif chemokine 1; Platelet-derived growth factor-inducible protein KC; Secretory protein N51
 Protein Family    KCNQ1 downstream neighbor protein
 UniProt Gene Name    Cxcl1 [Similar Products]
 UniProt Synonym Gene Names    Gro; Gro1; Mgsa; Scyb1; HSF [Similar Products]
 UniProt Entry Name    GROA_MOUSE
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 NCBI Summary for KC    This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung. [provided by RefSeq, Apr 2013]
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 UniProt Comments for KC    CXCL2: Produced by activated monocytes and neutrophils and expressed at sites of inflammation. Hematoregulatory chemokine, which, in vitro, suppresses hematopoietic progenitor cell proliferation. GRO-beta(5-73) shows a highly enhanced hematopoietic activity. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide

Cellular Component: extracellular space; cell; extracellular region; cytosol

Molecular Function: growth factor activity; chemokine activity; CXCR chemokine receptor binding; cytokine activity

Biological Process: neutrophil chemotaxis; G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; positive regulation of superoxide release; response to molecule of bacterial origin; positive regulation of potassium ion transport; response to lipopolysaccharide; positive regulation of leukocyte chemotaxis; immune response; inflammatory response; acute inflammatory response; regulation of cell proliferation
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 Research Articles on KC    1. Zfp30 is expressed in airway epithelia in the normal mouse lung and Zfp30 expression in vitro affects CXCL1 responses to an immune stimulus.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KC antibodyDiseases associated with anti-KC antibody
 Reference Product  PubMed Publications
 Cxcl2 antibody  >599 publications with KC and Cxcl2
 Cxcr2 antibody  >343 publications with KC and Cxcr2
 Ccl5 antibody  >265 publications with KC and Ccl5
 Cxcl5 antibody  >241 publications with KC and Cxcl5
 Cxcl10 antibody  >223 publications with KC and Cxcl10
 Ccl20 antibody  >108 publications with KC and Ccl20
 Cxcr1 antibody  >102 publications with KC and Cxcr1
 Cxcl13 antibody  >26 publications with KC and Cxcl13
 Cxcl16 antibody  >21 publications with KC and Cxcl16
 Ccl9 antibody  >7 publications with KC and Ccl9
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1261 publications with KC and Inflammation
 Necrosis Antibodies  >599 publications with KC and Necrosis
 Disease Models, Animal Antibodies  >463 publications with KC and Disease Models, Animal
 Lung Diseases Antibodies  >358 publications with KC and Lung Diseases
 Cardiovascular Diseases Antibodies  >208 publications with KC and Cardiovascular Diseases
 Lung Injury Antibodies  >182 publications with KC and Lung Injury
 Pneumonia Antibodies  >125 publications with KC and Pneumonia
 Fibrosis Antibodies  >104 publications with KC and Fibrosis
 Wounds and Injuries Antibodies  >102 publications with KC and Wounds and Injuries
 Reperfusion Injury Antibodies  >101 publications with KC and Reperfusion Injury
Organs/Tissues associated with anti-KC antibody
 Organ/Tissue Name  Pubmed Publications
 Connective Tissue Antibodies  >72 publications with KC and Connective Tissue
 Embryonic Tissue Antibodies  >46 publications with KC and Embryonic Tissue
 Spinal Cord Antibodies  >34 publications with KC and Spinal Cord
 Adipose Tissue Antibodies  >25 publications with KC and Adipose Tissue
 Ovary Antibodies  >17 publications with KC and Ovary
 Mammary Gland Antibodies  >12 publications with KC and Mammary Gland
 Extraembryonic Tissue Antibodies  >1 publications with KC and Extraembryonic Tissue
 Testis Antibodies  >1 publications with KC and Testis
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