NP_001035959.1
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
120,467 Da
NCBI Official Full Name
solute carrier family 12 member 6 isoform c
NCBI Official Synonym Full Names
solute carrier family 12 member 6
NCBI Protein Information
solute carrier family 12 member 6
UniProt Protein Name
Solute carrier family 12 member 6
UniProt Synonym Protein Names
Electroneutral potassium-chloride cotransporter 3; K-Cl cotransporter 3
UniProt Synonym Gene Names
UniProt Entry Name
S12A6_HUMAN
NCBI Summary for SLC12A6
This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy. [provided by RefSeq, Jul 2008]
UniProt Comments for SLC12A6
KCC3: Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells. Homomultimer and heteromultimer with other K-Cl cotransporters. Up-regulated by VEGF. Down-regulated by TNF. Highly expressed in heart, brain and kidney. Detected at lower levels in skeletal muscle, placenta, lung and pancreas. Detected in umbilical vein endothelial cells. Isoform 2 is more abundant in kidney. Isoform 5 is testis specific. Expressed in the proximal tubule of the kidney. Activated by N-ethylmaleimide (NEM). Inhibited by DIOA, bumetanide and furosemide. Inhibited by WNK3. Belongs to the SLC12A transporter family. 6 isoforms of the human protein are produced by alternative promoter.
Protein type: Transporter, SLC family; Transporter; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 15q13
Cellular Component: basolateral plasma membrane; integral to membrane; integral to plasma membrane; plasma membrane
Molecular Function: potassium ion symporter activity; potassium ion transmembrane transporter activity; potassium:chloride symporter activity; protein kinase binding
Biological Process: angiogenesis; ion transport; potassium ion import; synaptic transmission
Disease: Agenesis Of The Corpus Callosum With Peripheral Neuropathy
Research Articles on SLC12A6
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Products associated with anti-SLC12A6 antibody
Pathways associated with anti-SLC12A6 antibody
Diseases associated with anti-SLC12A6 antibody
Organs/Tissues associated with anti-SLC12A6 antibody
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