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anti-SLC12A6 antibody :: Goat KCC3/SLC12A6 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS420679
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

KCC3/SLC12A6, Polyclonal Antibody

 Also Known As   

Goat anti-KCC3/SLC12A6 Antibody

 Product Synonym Names    SLC12A6; KCC3; solute carrier family 12 (potassium/chloride transporters), member 6; ACCPN; DKFZP434D2135; KCC3A; KCC3B; agenesis of corpus callosum and peripheral neuropathy (Andermann syndrome); potassium chloride cotransporter 3; potassium chloride c; SLC12A6 antibody; KCC3 antibody; solute carrier family 12 (potassium/chloride transporters); member 6 antibody; ACCPN antibody; DKFZP434D2135 antibody; KCC3A antibody; KCC3B antibody; agenesis of corpus callosum and peripheral neuropathy (Andermann syndrome) antibody; potassium chloride cotransporter 3 antibody; potassium chloride c antibody; KCC3 / SLC12A6
 Product Gene Name   

anti-SLC12A6 antibody

[Similar Products]
 Product Synonym Gene Name    KCC3 [Similar Products]
 Matching Pairs    Unconjugated Antibody: KCC3/SLC12A6 (MBS420679)
Biotin Conjugated Antibody: KCC3 / SLC12A6 (MBS423681)
 Antibody/Peptide Pairs    KCC3 / SLC12A6 peptide (MBS426314) is used for blocking the activity of KCC3/SLC12A6 antibody (MBS420679)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    SRHIDVCSKT KE
 OMIM    218000
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence SRHIDVCSKTKE, from the internal region of the protein sequence according to NP_001035959.1; NP_001035960.1; NP_001035961.1; NP_001035962.1; NP_005126.1; NP_598408.1.
 Epitope    Internal region
 Note    This antibody is expected to recognise all 6 reported isofoms (NP_598408.1; NP_005126.1; NP_001035959.1; NP_001035960.1; NP_001035961.1; NP_001035962.1;);
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-SLC12A6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-SLC12A6 antibody   

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-SLC12A6 antibody    Peptide ELISA: Antibody detection limit dilution 1: 16000.
Immunohistochemistry: In paraffin embedded Human Heart shows staining of myocardial fibrils in transverse section. Recommended concentration, 2-4ug/ml.
Western Blot: Approx 120kDa band observed in Human Heart and Kidney lysates (calculated MW ranging 121-128kDa according to NP_598408.1; NP_005126.1; NP_001035959.1; NP_001035960.1; NP_001035961.1; NP_001035962.1). Recommended concentration: 0.1-0.3ug/ml.
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 Western Blot (WB) of anti-SLC12A6 antibody    (0.1ug/ml) staining of Human Heart lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-SLC12A6 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-SLC12A6 antibody    (2.5ug/ml) staining of paraffin embedded Human Heart. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-SLC12A6 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for SLC12A6. It may not necessarily be applicable to this product.
 NCBI GI #    110224452
 NCBI GeneID    9990
 NCBI Accession #    NP_001035959.1 [Other Products]
 NCBI Related Accession #    NP_001035960.1; NP_001035961.1; NP_001035962.1; NP_005126.1; NP_598408.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001042494.1 [Other Products]
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 UniProt Secondary Accession #    Q2VI00; Q7Z2E7; Q7Z4G5; Q8TDD4; Q9UFR2; Q9Y642; Q9Y665; A0AV76 [Other Products]
 UniProt Related Accession #    Q9UHW9 [Other Products]
 Molecular Weight    120,467 Da
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 NCBI Official Full Name    solute carrier family 12 member 6 isoform c
 NCBI Official Synonym Full Names    solute carrier family 12 member 6
 NCBI Official Symbol    SLC12A6 [Similar Products]
 NCBI Official Synonym Symbols   
[Similar Products]
 NCBI Protein Information    solute carrier family 12 member 6
 UniProt Protein Name    Solute carrier family 12 member 6
 UniProt Synonym Protein Names   
Electroneutral potassium-chloride cotransporter 3; K-Cl cotransporter 3
 Protein Family    Solute carrier family
 UniProt Gene Name    SLC12A6 [Similar Products]
 UniProt Synonym Gene Names    KCC3 [Similar Products]
 UniProt Entry Name    S12A6_HUMAN
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 NCBI Summary for SLC12A6    This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy. [provided by RefSeq, Jul 2008]
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 UniProt Comments for SLC12A6    KCC3: Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells. Homomultimer and heteromultimer with other K-Cl cotransporters. Up-regulated by VEGF. Down-regulated by TNF. Highly expressed in heart, brain and kidney. Detected at lower levels in skeletal muscle, placenta, lung and pancreas. Detected in umbilical vein endothelial cells. Isoform 2 is more abundant in kidney. Isoform 5 is testis specific. Expressed in the proximal tubule of the kidney. Activated by N-ethylmaleimide (NEM). Inhibited by DIOA, bumetanide and furosemide. Inhibited by WNK3. Belongs to the SLC12A transporter family. 6 isoforms of the human protein are produced by alternative promoter.

Protein type: Transporter, SLC family; Transporter; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 15q13

Cellular Component: basolateral plasma membrane; integral to membrane; integral to plasma membrane; plasma membrane

Molecular Function: potassium ion symporter activity; potassium ion transmembrane transporter activity; potassium:chloride symporter activity; protein kinase binding

Biological Process: angiogenesis; ion transport; potassium ion import; synaptic transmission

Disease: Agenesis Of The Corpus Callosum With Peripheral Neuropathy
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 Research Articles on SLC12A6    1. These results suggest that the expression of KCC3 in ESCC may affect cellular invasion and be related to a worse prognosis in patients with ESCC.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-SLC12A6 antibodyPathways associated with anti-SLC12A6 antibody
 Reference Product  PubMed Publications
 SPG11 antibody  >2 publications with SLC12A6 and SPG11
 WNK3 antibody  >2 publications with SLC12A6 and WNK3
 STK39 antibody  >2 publications with SLC12A6 and STK39
 WNK4 antibody  >1 publications with SLC12A6 and WNK4
 ZFYVE26 antibody  >1 publications with SLC12A6 and ZFYVE26
 MMP2 antibody  >1 publications with SLC12A6 and MMP2
 Products by Pathway  Pathway Diagram
 Cation-coupled Chloride Cotransporters Pathway antibodies  Cation-coupled Chloride Cotransporters Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway antibodies  Transport Of Inorganic Cations/anions And Amino Acids/oligopeptides Pathway Diagram
Diseases associated with anti-SLC12A6 antibodyOrgans/Tissues associated with anti-SLC12A6 antibody
 Disease Name  Pubmed Publications
 Peripheral Nervous System Diseases Antibodies  >16 publications with SLC12A6 and Peripheral Nervous System Diseases
 Nervous System Malformations Antibodies  >14 publications with SLC12A6 and Nervous System Malformations
 Hypertension Antibodies  >5 publications with SLC12A6 and Hypertension
 Disease Models, Animal Antibodies  >4 publications with SLC12A6 and Disease Models, Animal
 Nerve Degeneration Antibodies  >3 publications with SLC12A6 and Nerve Degeneration
 Anemia Antibodies  >3 publications with SLC12A6 and Anemia
 Corpus callosum agenesis neuronopathy Antibodies  >3 publications with SLC12A6 and Corpus callosum agenesis neuronopathy
 Paralysis Antibodies  >1 publications with SLC12A6 and Paralysis
 Neoplasms, Experimental Antibodies  >1 publications with SLC12A6 and Neoplasms, Experimental
 Immune System Diseases Antibodies  >1 publications with SLC12A6 and Immune System Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >23 publications with SLC12A6 and Brain
 Blood Antibodies  >12 publications with SLC12A6 and Blood
 Kidney Antibodies  >8 publications with SLC12A6 and Kidney
 Muscle Antibodies  >8 publications with SLC12A6 and Muscle
 Heart Antibodies  >3 publications with SLC12A6 and Heart
 Liver Antibodies  >2 publications with SLC12A6 and Liver
 Vascular Antibodies  >2 publications with SLC12A6 and Vascular
 Embryonic Tissue Antibodies  >2 publications with SLC12A6 and Embryonic Tissue
 Lung Antibodies  >2 publications with SLC12A6 and Lung
 Stomach Antibodies  >2 publications with SLC12A6 and Stomach
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