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anti-KCND3 antibody :: Rabbit KCND3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9126296
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

KCND3, Polyclonal Antibody

 Also Known As   

KCND3

 Product Gene Name   

anti-KCND3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 607346
 3D Structure    ModBase 3D Structure for Q9UK17
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Species    Human
 Immunogen    Recombinant Protein
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 Other Notes    Small volumes of anti-KCND3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-KCND3 antibody    Polyclonal
 Applications Tested/Suitable for anti-KCND3 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-KCND3 antibody    Western blot analysis of extracts of various cell lines, using KCND3 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Basic Kit.
Exposure time: 90s.
anti-KCND3 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-KCND3 antibody    Immunohistochemistry of paraffin-embedded mouse brain using KCND3 antibody at dilution of 1:100 (40x lens).
anti-KCND3 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for KCND3. It may not necessarily be applicable to this product.
 NCBI GI #    92090984
 NCBI GeneID    3752
 NCBI Accession #    Q9UK17.3 [Other Products]
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 UniProt Primary Accession #    Q9UK17 [Other Products]
 UniProt Secondary Accession #    O60576; O60577; Q14D71; Q5T0M0; Q9UH85; Q9UH86; Q9UK16 [Other Products]
 UniProt Related Accession #    Q9UK17 [Other Products]
 Molecular Weight    655
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 NCBI Official Full Name    Potassium voltage-gated channel subfamily D member 3
 NCBI Official Synonym Full Names    potassium voltage-gated channel, Shal-related subfamily, member 3
 NCBI Official Symbol    KCND3 [Similar Products]
 NCBI Official Synonym Symbols   
KV4.3; SCA19; SCA22; KCND3L; KCND3S; KSHIVB
[Similar Products]
 NCBI Protein Information    potassium voltage-gated channel subfamily D member 3; voltage-gated K+ channel; potassium ionic channel Kv4.3; sha1-related potassium channel Kv4.3; voltage-gated potassium channel subunit Kv4.3
 UniProt Protein Name    Potassium voltage-gated channel subfamily D member 3
 UniProt Synonym Protein Names   
Voltage-gated potassium channel subunit Kv4.3
 Protein Family    Potassium voltage-gated channel subfamily
 UniProt Gene Name    KCND3 [Similar Products]
 UniProt Entry Name    KCND3_HUMAN
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 NCBI Summary for KCND3    Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for KCND3    Kv4.3: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. KCND3 rare variants may confer risk for lethal ventricular arrhytmias and be associated with autopsy-negative sudden unexplained death syndrome (SUDS). Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.3/KCND3 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, potassium

Chromosomal Location of Human Ortholog: 1p13.3

Cellular Component: voltage-gated potassium channel complex; cell soma; dendrite; plasma membrane; sarcolemma

Molecular Function: protein binding; metal ion binding; delayed rectifier potassium channel activity; A-type (transient outward) potassium channel activity

Biological Process: synaptic transmission; potassium ion transport; protein homooligomerization

Disease: Brugada Syndrome 9; Spinocerebellar Ataxia 19
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 Research Articles on KCND3    1. maps to chromosome 1p21-q21 and identification in Dutch autosomal dominant cerebellar ataxia family
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KCND3 antibodyPathways associated with anti-KCND3 antibody
 Reference Product  PubMed Publications
 KCNQ1 antibody  >13 publications with KCND3 and KCNQ1
 KCNH2 antibody  >6 publications with KCND3 and KCNH2
 KCNIP1 antibody  >5 publications with KCND3 and KCNIP1
 KCNC4 antibody  >1 publications with KCND3 and KCNC4
 Products by Pathway  Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Voltage Gated Potassium Channels Pathway antibodies  Voltage Gated Potassium Channels Pathway Diagram
Diseases associated with anti-KCND3 antibodyOrgans/Tissues associated with anti-KCND3 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >37 publications with KCND3 and Cardiovascular Diseases
 Heart Diseases Antibodies  >36 publications with KCND3 and Heart Diseases
 Arrhythmias, Cardiac Antibodies  >28 publications with KCND3 and Arrhythmias, Cardiac
 Heart Failure Antibodies  >7 publications with KCND3 and Heart Failure
 Atrial Fibrillation Antibodies  >7 publications with KCND3 and Atrial Fibrillation
 Hypertrophy Antibodies  >7 publications with KCND3 and Hypertrophy
 Tachycardia Antibodies  >5 publications with KCND3 and Tachycardia
 Cardiomegaly Antibodies  >4 publications with KCND3 and Cardiomegaly
 Myocardial Infarction Antibodies  >4 publications with KCND3 and Myocardial Infarction
 Syncope Antibodies  >3 publications with KCND3 and Syncope
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >25 publications with KCND3 and Brain
 Lung Antibodies  >5 publications with KCND3 and Lung
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