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anti-KCNE1 antibody :: Rabbit anti-Human KCNE1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7048508
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

KCNE1, Polyclonal Antibody

★Popular Item★
 Also Known As   

KCNE1 Antibody

 Product Synonym Names    Potassium voltage-gated channel subfamily E member 1; Delayed rectifier potassium channel subunit IsK; IKs producing slow voltage-gated potassium channel subunit beta Min; KCNE1
 Product Gene Name   

anti-KCNE1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    M26685 Genomic DNA
 3D Structure    ModBase 3D Structure for P15382
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant Human Potassium voltage-gated channel subfamily E member 1 protein (85-129AA)
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, PH 7.4
 Conjugation    Non-conjugated
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-16796
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-KCNE1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-KCNE1 antibody

   Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 (PubMed: 19219384). Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr).
 Applications Tested/Suitable for anti-KCNE1 antibody   

ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-KCNE1 antibody    IHC: 1: 20-1: 200
IF: 1: 50-1: 200
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 Immunohistochemistry (IHC) of anti-KCNE1 antibody    Immunohistochemistry of paraffin-embedded human small intestine tissue using MBS7048508 at dilution of 1:100
anti-KCNE1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-KCNE1 antibody    Immunofluorescent analysis of HepG2 cells using MBS7048508 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-KCNE1 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for KCNE1. It may not necessarily be applicable to this product.
 NCBI GI #    60218915
 NCBI GeneID    3753
 NCBI Accession #    NP_000210.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000219.5 [Other Products]
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 UniProt Primary Accession #    P15382 [Other Products]
 UniProt Secondary Accession #    Q8N709; Q91Z94; A5H1P2 [Other Products]
 UniProt Related Accession #    P15382 [Other Products]
 Molecular Weight    14,675 Da
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 NCBI Official Full Name    potassium voltage-gated channel subfamily E member 1
 NCBI Official Synonym Full Names    potassium voltage-gated channel subfamily E regulatory subunit 1
 NCBI Official Symbol    KCNE1 [Similar Products]
 NCBI Official Synonym Symbols   
ISK; JLNS; LQT5; MinK; JLNS2; LQT2/5
[Similar Products]
 NCBI Protein Information    potassium voltage-gated channel subfamily E member 1
 UniProt Protein Name    Potassium voltage-gated channel subfamily E member 1
 UniProt Synonym Protein Names   
Delayed rectifier potassium channel subunit IsK; IKs producing slow voltage-gated potassium channel subunit beta Mink; Minimal potassium channel
 Protein Family    Potassium voltage-gated channel subfamily
 UniProt Gene Name    KCNE1 [Similar Products]
 UniProt Entry Name    KCNE1_HUMAN
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 NCBI Summary for KCNE1    The product of this gene belongs to the potassium channel KCNE family. Potassium ion channels are essential to many cellular functions and show a high degree of diversity, varying in their electrophysiologic and pharmacologic properties. This gene encodes a transmembrane protein known to associate with the product of the KVLQT1 gene to form the delayed rectifier potassium channel. Mutation in this gene are associated with both Jervell and Lange-Nielsen and Romano-Ward forms of long-QT syndrome. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
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 UniProt Comments for KCNE1    KCNE1: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr). Associates with KCNQ1/KVLQT1 and KCNH2/HERG. Expressed in heart, lung, kidney, testis, ovaries, small intestine, peripheral blood leukocytes. Not detected in pancreas, spleen, prostate and colon. Restrictively localized in the apical membrane portion of epithelial cells. Belongs to the potassium channel KCNE family.

Protein type: Channel, potassium; Membrane protein, integral

Chromosomal Location of Human Ortholog: 21q22.12

Cellular Component: apical plasma membrane; cell surface; lysosome; plasma membrane; voltage-gated potassium channel complex; Z disc

Molecular Function: delayed rectifier potassium channel activity; potassium channel regulator activity; protein binding; telethonin binding; voltage-gated potassium channel activity

Biological Process: protein amino acid N-linked glycosylation; protein amino acid O-linked glycosylation; sensory perception of sound

Disease: Jervell And Lange-nielsen Syndrome 2; Long Qt Syndrome 5
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 Research Articles on KCNE1    1. A stoichiometry of 4:4 between the alpha KCNE1 and the beta KCNQ1-subunits has been established.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KCNE1 antibodyPathways associated with anti-KCNE1 antibody
 Reference Product  PubMed Publications
 KCNQ1 antibody  >558 publications with KCNE1 and KCNQ1
 KCNH2 antibody  >154 publications with KCNE1 and KCNH2
 SCN5A antibody  >133 publications with KCNE1 and SCN5A
 AKAP9 antibody  >15 publications with KCNE1 and AKAP9
 ANK2 antibody  >13 publications with KCNE1 and ANK2
 Products by Pathway  Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Adrenergic Signaling In Cardiomyocytes Pathway antibodies  Adrenergic Signaling In Cardiomyocytes Pathway Diagram
 Cardiac Conduction Pathway antibodies  Cardiac Conduction Pathway Diagram
 Muscle Contraction Pathway antibodies  Muscle Contraction Pathway Diagram
 Phase 2 - Plateau Phase Pathway antibodies  Phase 2 - Plateau Phase Pathway Diagram
 Phase 3 - Rapid Repolarisation Pathway antibodies  Phase 3 - Rapid Repolarisation Pathway Diagram
 TarBasePathway antibodies  TarBasePathway Diagram
Diseases associated with anti-KCNE1 antibodyOrgans/Tissues associated with anti-KCNE1 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >354 publications with KCNE1 and Cardiovascular Diseases
 Heart Diseases Antibodies  >349 publications with KCNE1 and Heart Diseases
 Arrhythmias, Cardiac Antibodies  >346 publications with KCNE1 and Arrhythmias, Cardiac
 Long QT Syndrome Antibodies  >299 publications with KCNE1 and Long QT Syndrome
 Jervell-Lange Nielsen Syndrome Antibodies  >48 publications with KCNE1 and Jervell-Lange Nielsen Syndrome
 Tachycardia, Ventricular Antibodies  >48 publications with KCNE1 and Tachycardia, Ventricular
 Nervous System Diseases Antibodies  >37 publications with KCNE1 and Nervous System Diseases
 Hypertension Antibodies  >21 publications with KCNE1 and Hypertension
 Ventricular Fibrillation Antibodies  >21 publications with KCNE1 and Ventricular Fibrillation
 Jervell And Lange-Nielsen Syndrome 2 Antibodies  >18 publications with KCNE1 and Jervell And Lange-Nielsen Syndrome 2
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >53 publications with KCNE1 and Blood
 Kidney Antibodies  >47 publications with KCNE1 and Kidney
 Brain Antibodies  >29 publications with KCNE1 and Brain
 Intestine Antibodies  >19 publications with KCNE1 and Intestine
 Lung Antibodies  >12 publications with KCNE1 and Lung
 Nerve Antibodies  >9 publications with KCNE1 and Nerve
 Testis Antibodies  >4 publications with KCNE1 and Testis
 Eye Antibodies  >2 publications with KCNE1 and Eye
 Pharynx Antibodies  >1 publications with KCNE1 and Pharynx
 Trachea Antibodies  >1 publications with KCNE1 and Trachea
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