NP_751951.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
potassium voltage-gated channel subfamily E member 2
NCBI Official Synonym Full Names
potassium channel, voltage gated subfamily E regulatory beta subunit 2
NCBI Protein Information
potassium voltage-gated channel subfamily E member 2
UniProt Protein Name
Potassium voltage-gated channel subfamily E member 2
UniProt Synonym Protein Names
MinK-related peptide 1; Minimum potassium ion channel-related peptide 1; Potassium channel subunit beta MiRP1
UniProt Entry Name
KCNE2_HUMAN
NCBI Summary for KCNE2
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia. [provided by RefSeq, Jul 2008]
UniProt Comments for KCNE2
KCNE2: Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Associated with KCNH2/HERG is proposed to form the rapidly activating component of the delayed rectifying potassium current in heart (IKr). May associate with KCNQ2 and/or KCNQ3 and modulate the native M-type current. May associate with KCNQ1/KVLTQ1 and elicit a voltage-independent current. May associate with HCN1 and HCN2 and increase potassium current. Defects in KCNE2 are the cause of long QT syndrome type 6 (LQT6). Long QT syndromes are heart disorders characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress. KCNE2 mutants form channels that open slowly and close rapidly, thereby diminishing potassium currents. Defects in KCNE2 are the cause of familial atrial fibrillation type 4 (ATFB4). Atrial fibrillation is a common disorder of cardiac rhythm that is hereditary in a small subgroup of patients. It is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. Belongs to the potassium channel KCNE family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 21q22.12
Cellular Component: voltage-gated potassium channel complex; cell surface; lysosome; plasma membrane
Molecular Function: protein homodimerization activity; potassium channel regulator activity; delayed rectifier potassium channel activity; inward rectifier potassium channel activity
Biological Process: tongue development; potassium ion import; aging
Disease: Long Qt Syndrome 6; Atrial Fibrillation, Familial, 4
Product References and Citations for anti-KCNE2 antibody
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Albert, C.M., et al. Circ Arrhythm Electrophysiol 3(3):222-229(2010) Subbiah, R.N., et al. Can J Cardiol 26(4):208-212(2010) Tam, G.W., et al. Biochem. Soc. Trans. 38(2):445-451(2010) Roepke, T.K., et al. PLoS ONE 5 (7), E11451 (2010) :
Research Articles on KCNE2
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Products associated with anti-KCNE2 antibody
Diseases associated with anti-KCNE2 antibody
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