NP_055406.2
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
21,401 Da
NCBI Official Full Name
Kv channel-interacting protein 2 isoform 1
NCBI Official Synonym Full Names
potassium voltage-gated channel interacting protein 2
NCBI Official Synonym Symbols
NCBI Protein Information
Kv channel-interacting protein 2
UniProt Protein Name
Kv channel-interacting protein 2
UniProt Synonym Protein Names
A-type potassium channel modulatory protein 2; Cardiac voltage-gated potassium channel modulatory subunit; Potassium channel-interacting protein 2
UniProt Synonym Gene Names
NCBI Summary for KCNIP2/KCHIP2
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified from this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for KCNIP2/KCHIP2
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart ().
Research Articles on KCNIP2/KCHIP2
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Pathways associated with anti-KCNIP2/KCHIP2 antibody
Diseases associated with anti-KCNIP2/KCHIP2 antibody
Organs/Tissues associated with anti-KCNIP2/KCHIP2 antibody
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