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anti-KCNJ1 antibody :: Goat KCNJ1/ROMK Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS422048
Western Blot (WB)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

KCNJ1/ROMK, Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-KCNJ1/ROMK Antibody

 Product Synonym Names    KCNJ1; potassium inwardly-rectifying channel, subfamily J, member 1; KIR1.1, ROMK, ROMK1; ATP-regulated potassium channel ROM-K; ATP-sensitive inward rectifier potassium channel 1; OTTHUMP00000045938; inwardly rectifying K+ channel; potassium inwardly-rec; KCNJ1 antibody; potassium inwardly-rectifying channel; subfamily J; member 1 antibody; KIR1.1; ROMK; ROMK1 antibody; ATP-regulated potassium channel ROM-K antibody; ATP-sensitive inward rectifier potassium channel 1 antibody; OTTHUMP00000045938 antibody; inwardly rectifying K+ channel antibody; potassium inwardly-rectifying channel J1 antibody; KCNJ1 / ROMK
 Product Gene Name   

anti-KCNJ1 antibody

[Similar Products]
 Product Synonym Gene Name    ROMK [Similar Products]
 Antibody/Peptide Pairs    KCNJ1 / ROMK peptide (MBS425295) is used for blocking the activity of KCNJ1/ROMK antibody (MBS422048)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    DQININFVVD AGNEN
 OMIM    241200
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-DQININFVVDAGNEN, from the internal region of the protein sequence according to NP_000211.1; NP_722448.1.
 Epitope    Internal region
 Note    This antibody is expected to recognize reported isoforms NP_722449.2 and NP_000211. The following reported variants represent identical protein: NP_722451.1, NP_722449.2, NP_722450.1, NP_722448.1.
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-KCNJ1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-KCNJ1 antibody   

Peptide ELISA (EIA), Western Blot (WB)

 Application Notes for anti-KCNJ1 antibody    Peptide ELISA: Antibody detection limit dilution 1: 8000.
Western Blot: approx. 45kDa band observed in Human, Mouse and Rat Kidney lysates (calculated MW of 44.8kDa according to NP_000211.1). Recommended concentration: 1-3ug/ml.
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 Western Blot (WB) of anti-KCNJ1 antibody    (1ug/ml) staining of Human Kidney lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-KCNJ1 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for KCNJ1. It may not necessarily be applicable to this product.
 NCBI GI #    4504837
 NCBI GeneID    3758
 NCBI Accession #    NP_000211.1 [Other Products]
 NCBI Related Accession #    NP_722448.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000220.4 [Other Products]
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 UniProt Secondary Accession #    Q6LD67; B2RMR4 [Other Products]
 UniProt Related Accession #    P48048 [Other Products]
 Molecular Weight    44,611 Da
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 NCBI Official Full Name    ATP-sensitive inward rectifier potassium channel 1 isoform a
 NCBI Official Synonym Full Names    potassium voltage-gated channel subfamily J member 1
 NCBI Official Symbol    KCNJ1 [Similar Products]
 NCBI Official Synonym Symbols   
ROMK; ROMK1; KIR1.1
[Similar Products]
 NCBI Protein Information    ATP-sensitive inward rectifier potassium channel 1
 UniProt Protein Name    ATP-sensitive inward rectifier potassium channel 1
 UniProt Synonym Protein Names   
ATP-regulated potassium channel ROM-K; Inward rectifier K(+) channel Kir1.1; Potassium channel, inwardly rectifying subfamily J member 1
 Protein Family    ATP-sensitive inward rectifier potassium channel
 UniProt Gene Name    KCNJ1 [Similar Products]
 UniProt Synonym Gene Names    ROMK1 [Similar Products]
 UniProt Entry Name    KCNJ1_HUMAN
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 NCBI Summary for KCNJ1    Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for KCNJ1    ROMK: an inward rectifier-type potassium channel protein. Probably plays a major role in potassium homeostasis in the kidney. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. The channel is activated by internal ATP and can be blocked by external barium. High levels of expression in the kidney and pancreatic islets. Lower levels in skeletal muscle, pancreas, spleen, brain, heart and liver. Three alternatively spliced isoforms have been described.

Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q24

Cellular Component: plasma membrane; voltage-gated potassium channel complex

Molecular Function: ATP-activated inward rectifier potassium channel activity; inward rectifier potassium channel activity; phosphatidylinositol-4,5-bisphosphate binding

Biological Process: excretion; potassium ion import; potassium ion transport

Disease: Bartter Syndrome, Antenatal, Type 2
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 Research Articles on KCNJ1    1. WNK4 is a substrate of SFKs and the association of c-Src and PTP-1D with WNK4 at Tyr(1092) and Tyr(1143) plays an important role in modulating the inhibitory effect of WNK4 on ROMK
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KCNJ1 antibodyPathways associated with anti-KCNJ1 antibody
 Reference Product  PubMed Publications
 SLC12A1 antibody  >41 publications with KCNJ1 and SLC12A1
 WNK4 antibody  >20 publications with KCNJ1 and WNK4
 CLCNKB antibody  >18 publications with KCNJ1 and CLCNKB
 SRC antibody  >17 publications with KCNJ1 and SRC
 WNK1 antibody  >17 publications with KCNJ1 and WNK1
 SGK1 antibody  >13 publications with KCNJ1 and SGK1
 CFTR antibody  >12 publications with KCNJ1 and CFTR
 SLC9A3R2 antibody  >2 publications with KCNJ1 and SLC9A3R2
 Products by Pathway  Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Gastric Acid Secretion Pathway antibodies  Gastric Acid Secretion Pathway Diagram
 Gastric Acid Secretion Pathway antibodies  Gastric Acid Secretion Pathway Diagram
 Inwardly Rectifying K+ Channels Pathway antibodies  Inwardly Rectifying K+ Channels Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Potassium Transport Channels Pathway antibodies  Potassium Transport Channels Pathway Diagram
Diseases associated with anti-KCNJ1 antibodyOrgans/Tissues associated with anti-KCNJ1 antibody
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >77 publications with KCNJ1 and Kidney Diseases
 Bartter Syndrome Antibodies  >61 publications with KCNJ1 and Bartter Syndrome
 Hypertension Antibodies  >36 publications with KCNJ1 and Hypertension
 Cardiovascular Diseases Antibodies  >19 publications with KCNJ1 and Cardiovascular Diseases
 Fibrosis Antibodies  >12 publications with KCNJ1 and Fibrosis
 Disease Models, Animal Antibodies  >10 publications with KCNJ1 and Disease Models, Animal
 Acute Kidney Injury Antibodies  >5 publications with KCNJ1 and Acute Kidney Injury
 Necrosis Antibodies  >3 publications with KCNJ1 and Necrosis
 Carcinoma Antibodies  >3 publications with KCNJ1 and Carcinoma
 Brain Diseases Antibodies  >3 publications with KCNJ1 and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >192 publications with KCNJ1 and Kidney
 Liver Antibodies  >6 publications with KCNJ1 and Liver
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