NP_004972.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
49,500 Da
NCBI Official Full Name
inward rectifier potassium channel 4
NCBI Official Synonym Full Names
potassium voltage-gated channel subfamily J member 4
NCBI Official Synonym Symbols
HIR; HRK1; IRK3; HIRK2; IRK-3; Kir2.3 [Similar Products]
NCBI Protein Information
inward rectifier potassium channel 4
UniProt Protein Name
Inward rectifier potassium channel 4
UniProt Synonym Protein Names
HIRK2; HRK1; Hippocampal inward rectifier; HIR; Inward rectifier K(+) channel Kir2.3; IRK-3; Potassium channel, inwardly rectifying subfamily J member 4
UniProt Synonym Gene Names
UniProt Entry Name
KCNJ4_HUMAN
NCBI Summary for KCNJ4
Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for KCNJ4
HIR: This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium and cesium. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ4 subfamily.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, potassium
Chromosomal Location of Human Ortholog: 22q13.1
Cellular Component: basolateral plasma membrane; plasma membrane; voltage-gated potassium channel complex
Molecular Function: G-protein activated inward rectifier potassium channel activity; inward rectifier potassium channel activity; PDZ domain binding; protein binding
Biological Process: potassium ion import; potassium ion transport
Research Articles on KCNJ4
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Pathways associated with anti-KCNJ4 antibody
Diseases associated with anti-KCNJ4 antibody
Organs/Tissues associated with anti-KCNJ4 antibody
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