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anti-KCNJ5 antibody :: Rabbit KCNJ5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS540656
Western Blot (WB)
Unit / Price
0.1 mg Affinity-Purified  /  $390 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

KCNJ5, Polyclonal Antibody

 Also Known As   

GIRK4 Antibody Affinity Purified

 Product Synonym Names    Cardiac ATP sensitive potassium channel; Cardiac inward rectifier; CIR; G protein activated inward rectifier potassium channel 4; GIRK-4; Heart KATP channel; Inward rectifier K+ channel KIR3.4; IRK-4; KATP-1; KCNJ 5; KIR3.4; Potassium channel antibody
 Product Gene Name   

anti-KCNJ5 antibody

[Similar Products]
 Matching Pairs    Antibody: KCNJ5 (MBS540656)
Positive Control: KCNJ5 (MBS542802)
 Antibody/Peptide Pairs    KCNJ5 peptide (MBS543755) is used for blocking the activity of KCNJ5 antibody (MBS540656)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600734
 3D Structure    ModBase 3D Structure for P48544
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Form/Format    Affinity Purified
 Concentration    0.53-0.57 ug/ul in antibody stabilization buffer (lot specific)
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 Immunogen    Synthetic peptide taken within amino acid region 350-450 on human GIRK4 protein.
 Molecular Function    Potassium
 Structure    Belongs to inward rectifier-type potassium channel family
 Subcellular Location    Membrane; Multi-pass membrane protein
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 Preparation and Storage    -20 degree C for long term storage
 Other Notes    Small volumes of anti-KCNJ5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-KCNJ5 antibody

   Affinity Purified G protein-activated inward rectifier potassium channel 4 Antibody
 Product Categories/Family for anti-KCNJ5 antibody    Primary Antibodies; Neuroscience; Neurotransmission; KCNJ5 Antibody
 Applications Tested/Suitable for anti-KCNJ5 antibody   

ELISA (EIA), IMM, Western Blot (WB)

 Application Notes for anti-KCNJ5 antibody    Dot Blot: 1:10,000
ELISA: 1:10,000
Immunoprecipitation: 1:200
Western Blot: 1:250
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 Western Blot (WB) of anti-KCNJ5 antibody    anti-KCNJ5 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for KCNJ5. It may not necessarily be applicable to this product.
 NCBI GI #    24797141
 NCBI GeneID    3762
 NCBI Accession #    NP_000881 [Other Products]
 NCBI GenBank Nucleotide #    NM_000890.3 [Other Products]
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 UniProt Primary Accession #    P48544 [Other Products]
 UniProt Secondary Accession #    Q6DK13; Q6DK14; Q92807; B2R744 [Other Products]
 UniProt Related Accession #    P48544 [Other Products]
 Molecular Weight    47,668 Da
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 NCBI Official Full Name    G protein-activated inward rectifier potassium channel 4
 NCBI Official Synonym Full Names    potassium voltage-gated channel subfamily J member 5
 NCBI Official Symbol    KCNJ5 [Similar Products]
 NCBI Official Synonym Symbols   
CIR; GIRK4; KATP1; LQT13; KIR3.4
[Similar Products]
 NCBI Protein Information    G protein-activated inward rectifier potassium channel 4
 UniProt Protein Name    G protein-activated inward rectifier potassium channel 4
 UniProt Synonym Protein Names   
Cardiac inward rectifier; CIR; Heart KATP channel; Inward rectifier K(+) channel Kir3.4; IRK-4; KATP-1; Potassium channel, inwardly rectifying subfamily J member 5
 Protein Family    G protein-activated inward rectifier potassium channel
 UniProt Gene Name    KCNJ5 [Similar Products]
 UniProt Synonym Gene Names    GIRK4; GIRK-4; CIR; IRK-4 [Similar Products]
 UniProt Entry Name    KCNJ5_HUMAN
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 NCBI Summary for KCNJ5    Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It may associate with two other G-protein-activated potassium channels to form a heteromultimeric pore-forming complex. [provided by RefSeq, Jul 2008]
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 UniProt Comments for KCNJ5    GIRK4: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium. Defects in KCNJ5 are the cause of long QT syndrome type 13 (LQT13). It is a heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to excercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy. Defects in KCNJ5 are the cause of familial hyperaldosteronism type 3 (FH3). A form of hyperaldosteronism characterized by hypertension secondary to massive adrenal mineralocorticoid production. Like patients with familial hyperaldosteronism type 1 (glucocorticoid-remediable aldosteronism), patients with FH3 present with childhood hypertension, elevated aldosteronism levels, and high levels of the hybrid steroids 18-oxocortisol and 18-hydroxycortisol. However, hypertension and aldosteronism are not reversed by administration of exogenous glucocorticoids and patients require adrenalectomy to control hypertension. Somatic mutations in KCNJ5 have been found in aldosterone-producing adrenal adenomas and can be responsible for aldosteronism associated with cell autonomous proliferation. These are typically solitary, well circumscribed tumors diagnosed between ages 30 and 70. They come to medical attention due to new or worsening hypertension, often with hypokalemia. KCNJ5 mutations produce increased sodium conductance and cell depolarization, which in adrenal glomerulosa cells produces calcium entry, the signal for aldosterone production and cell proliferation. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Channel, potassium

Chromosomal Location of Human Ortholog: 11q24

Cellular Component: external side of plasma membrane; plasma membrane; T-tubule; voltage-gated potassium channel complex

Molecular Function: G-protein activated inward rectifier potassium channel activity; inward rectifier potassium channel activity; protein binding

Biological Process: potassium ion import; potassium ion transport

Disease: Hyperaldosteronism, Familial, Type Iii; Long Qt Syndrome 13
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 Research Articles on KCNJ5    1. In aldosterone-producing cells of an in vitro model of hyperaldosteronism GIRK4 does not form functional channels.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-KCNJ5 antibodyDiseases associated with anti-KCNJ5 antibody
 Products by Pathway  Pathway Diagram
 Activation Of G Protein Gated Potassium Channels Pathway antibodies  Activation Of G Protein Gated Potassium Channels Pathway Diagram
 Activation Of GABAB Receptors Pathway antibodies  Activation Of GABAB Receptors Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Circadian Entrainment Pathway antibodies  Circadian Entrainment Pathway Diagram
 Circadian Entrainment Pathway antibodies  Circadian Entrainment Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram
 Dopaminergic Synapse Pathway antibodies  Dopaminergic Synapse Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 Estrogen Signaling Pathway antibodies  Estrogen Signaling Pathway Diagram
 G Protein Gated Potassium Channels Pathway antibodies  G Protein Gated Potassium Channels Pathway Diagram
 Disease Name  Pubmed Publications
 Hypertension Antibodies  >80 publications with KCNJ5 and Hypertension
 Adenoma Antibodies  >79 publications with KCNJ5 and Adenoma
 Cardiovascular Diseases Antibodies  >44 publications with KCNJ5 and Cardiovascular Diseases
 Hyperplasia Antibodies  >33 publications with KCNJ5 and Hyperplasia
 Heart Diseases Antibodies  >23 publications with KCNJ5 and Heart Diseases
 Arrhythmias, Cardiac Antibodies  >20 publications with KCNJ5 and Arrhythmias, Cardiac
 Death Antibodies  >9 publications with KCNJ5 and Death
 Nervous System Diseases Antibodies  >6 publications with KCNJ5 and Nervous System Diseases
 Myocardial Infarction Antibodies  >5 publications with KCNJ5 and Myocardial Infarction
 Seizures Antibodies  >2 publications with KCNJ5 and Seizures
Organs/Tissues associated with anti-KCNJ5 antibody
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >3 publications with KCNJ5 and Lung
 Bone Antibodies  >2 publications with KCNJ5 and Bone
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