NP_001265840.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
calcium-activated potassium channel subunit beta-2
NCBI Official Synonym Full Names
potassium channel subfamily M regulatory beta subunit 2
NCBI Protein Information
calcium-activated potassium channel subunit beta-2
UniProt Protein Name
Calcium-activated potassium channel subunit beta-2
UniProt Synonym Protein Names
BK channel subunit beta-2; BKbeta2; Hbeta2; Calcium-activated potassium channel, subfamily M subunit beta-2; Charybdotoxin receptor subunit beta-2; Hbeta3; K(VCA)beta-2; Maxi K channel subunit beta-2; Slo-beta-2
UniProt Synonym Gene Names
UniProt Entry Name
KCMB2_HUMAN
NCBI Summary for KCNMB2
MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full length nature has not been described. [provided by RefSeq, Jul 2013]
UniProt Comments for KCNMB2
KCNMB2: Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons. Belongs to the KCNMB (TC 8.A.14.1) family. KCNMB2 subfamily.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 3q26.32
Cellular Component: voltage-gated potassium channel complex; integral to plasma membrane; plasma membrane
Molecular Function: calcium-activated potassium channel activity; potassium channel regulator activity; ion channel inhibitor activity
Biological Process: synaptic transmission; regulation of action potential; regulation of vasoconstriction; generation of action potential; detection of calcium ion; blood coagulation; potassium ion transport
Product References and Citations for anti-KCNMB2 antibody
Trevino, L.R., et al. Nat. Genet. 41(9):1001-1005(2009) Lee, U.S., et al. J. Physiol. (Lond.) 587 (PT 7), 1481-1498 (2009) : Zarei, M.M., et al. Neuroscience 147(1):80-89(2007) Zeng, X.H., et al. J. Neurosci. 27(17):4707-4715(2007) Orio, P., et al. J. Gen. Physiol. 127(2):191-204(2006)
Research Articles on KCNMB2
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Products associated with anti-KCNMB2 antibody
Pathways associated with anti-KCNMB2 antibody
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Diseases associated with anti-KCNMB2 antibody
Organs/Tissues associated with anti-KCNMB2 antibody
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