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anti-KCNN2 antibody :: Goat KCNN2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS422106
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

KCNN2, Polyclonal Antibody

★Popular Item★
 Also Known As   

Goat anti-KCNN2 Antibody

 Product Synonym Names    KCNN2; potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2; KCa2.2; SK2; SKCA2; hSK2; apamin-sensitive small-conductance Ca2+-activated potassium channel; small conductance calcium-activated potassium channel protein; KCNN2 antibody; potassium intermediate/small conductance calcium-activated channel; subfamily N; member 2 antibody; KCa2.2 antibody; SK2 antibody; SKCA2 antibody; hSK2 antibody; apamin-sensitive small-conductance Ca2+-activated potassium channel antibody; small conductance calcium-activated potassium channel protein 2 antibody
 Product Gene Name   

anti-KCNN2 antibody

[Similar Products]
 Antibody/Peptide Pairs    KCNN2 peptide (MBS425445) is used for blocking the activity of KCNN2 antibody (MBS422106)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    ESYDKHVTYN AER
 OMIM    605879
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-ESYDKHVTYNAER, from the internal region of the protein sequence according to NP_067627.2; NP_740721.1.
 Epitope    Internal region
 Note    This antibody is expected to recognize both isoforms (NP_067627.2; NP_740721.1).
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-KCNN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-KCNN2 antibody   

Peptide ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-KCNN2 antibody    Peptide ELISA: Antibody detection limit dilution 1: 64000.
Immunohistochemistry: In paraffin embedded Humam Thyroid Gland shows membranous staining in the epithelial cells. Recommended concentration, 1-2ug/ml.
Western Blot: Approx 70kDa and 23kDa bands observed in Human Liver lysates (calculated MW of 63.8kDa according to NP_067627.2 and of 26.3kDa according to NP_740721.1). Recommended concentration: 0.3-1ug/ml.
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 Western Blot (WB) of anti-KCNN2 antibody    (0.3ug/ml) staining of Human Liver lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
anti-KCNN2 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-KCNN2 antibody    (3.8ug/ml) staining of paraffin embedded Human Thyroid Gland. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-KCNN2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for KCNN2. It may not necessarily be applicable to this product.
 NCBI GI #    25777645
 NCBI GeneID    3781
 NCBI Accession #    NP_067627.2 [Other Products]
 NCBI Related Accession #    NP_740721.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_021614.3 [Other Products]
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 UniProt Secondary Accession #    Q0VFZ4; Q6PJI0; Q6X2Y2; A6NF94 [Other Products]
 UniProt Related Accession #    Q9H2S1 [Other Products]
 Molecular Weight    26,341 Da
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 NCBI Official Full Name    small conductance calcium-activated potassium channel protein 2 isoform a
 NCBI Official Synonym Full Names    potassium calcium-activated channel subfamily N member 2
 NCBI Official Symbol    KCNN2 [Similar Products]
 NCBI Official Synonym Symbols   
SK2; hSK2; SKCA2; KCa2.2; SKCa 2
[Similar Products]
 NCBI Protein Information    small conductance calcium-activated potassium channel protein 2
 UniProt Protein Name    Small conductance calcium-activated potassium channel protein 2
 UniProt Synonym Protein Names   
KCa2.2
 Protein Family    Small conductance calcium-activated potassium channel protein
 UniProt Gene Name    KCNN2 [Similar Products]
 UniProt Synonym Gene Names    SK2; SKCa 2; SKCa2 [Similar Products]
 UniProt Entry Name    KCNN2_HUMAN
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 NCBI Summary for KCNN2    Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. This gene is a member of the KCNN family of potassium channel genes. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
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 UniProt Comments for KCNN2    KCNN2: Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin. Belongs to the potassium channel KCNN family. KCa2.2/KCNN2 subfamily.

Protein type: Membrane protein, integral; Channel, potassium; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 5q22.3

Cellular Component: cell soma; cell surface; dendritic spine; integral to membrane; plasma membrane; smooth endoplasmic reticulum; T-tubule; Z disc

Molecular Function: alpha-actinin binding; calcium-activated potassium channel activity; calmodulin binding; protein domain specific binding; protein homodimerization activity; small conductance calcium-activated potassium channel activity

Biological Process: potassium ion transport
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 Research Articles on KCNN2    1. Differentiated dopaminergic neurons expressed low levels of SK2 channels and high levels of SK1 and SK3 channels.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-KCNN2 antibodyDiseases associated with anti-KCNN2 antibody
 Products by Pathway  Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Bile Secretion Pathway antibodies  Bile Secretion Pathway Diagram
 Ca2+ Activated K+ Channels Pathway antibodies  Ca2+ Activated K+ Channels Pathway Diagram
 Insulin Secretion Pathway antibodies  Insulin Secretion Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Serotonergic Synapse Pathway antibodies  Serotonergic Synapse Pathway Diagram
 Disease Name  Pubmed Publications
 Heart Diseases Antibodies  >14 publications with KCNN2 and Heart Diseases
 Arrhythmias, Cardiac Antibodies  >9 publications with KCNN2 and Arrhythmias, Cardiac
 Disease Models, Animal Antibodies  >6 publications with KCNN2 and Disease Models, Animal
 Neurobehavioral Manifestations Antibodies  >4 publications with KCNN2 and Neurobehavioral Manifestations
 Inflammation Antibodies  >3 publications with KCNN2 and Inflammation
 Learning Disorders Antibodies  >2 publications with KCNN2 and Learning Disorders
 Mental Disorders Antibodies  >2 publications with KCNN2 and Mental Disorders
 Pain Antibodies  >2 publications with KCNN2 and Pain
 Seizures Antibodies  >2 publications with KCNN2 and Seizures
 Fibrosis Antibodies  >1 publications with KCNN2 and Fibrosis
Organs/Tissues associated with anti-KCNN2 antibody
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >53 publications with KCNN2 and Brain
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