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anti-KCNQ4 antibody :: Rabbit anti-Human, Mouse KCNQ4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9605775
Unit / Price
0.1 mL  /  $255 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

KCNQ4, Polyclonal Antibody

★Popular Item★
 Also Known As   

KCNQ4 Antibody

 Product Synonym Names    DFNA 2; DFNA2; KCNQ 4; Kcnq4; KCNQ4_HUMAN; KQT like 4; KQT-like 4; KV7.4; Potassium channel KQT like 4; Potassium channel subunit alpha KvLQT4; Potassium voltage gated channel KQT like protein 4; Potassium voltage gated channel KQT like subfamily member 4; Potassium voltage gated channel subfamily KQT member 4; Potassium voltage-gated channel subfamily KQT member 4; Voltage gated potassium channel subunit Kv7.4; Voltage-gated potassium channel subunit Kv7.4
 Product Gene Name   

anti-KCNQ4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for P56696
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    KCNQ4 antibody detects endogenous levels of total KCNQ4
 Purity/Purification    The antiserum was purified by peptide affinity chromatography using SulfoLink Coupling Resin.
 Form/Format    Liquid
Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1mg/ml (lot specific)
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 Immunogen    A synthesized peptide
 Subcellular Location    Basal Cell Membrane. Situated at the basal membrane of cochlear outer hair cells.
 Tissue Specificity    Expressed in the outer, but not the inner, sensory hair cells of the cochlea. Slightly expressed in heart, brain and skeletal muscle.
 Conjugation    Unconjugated
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 Preparation and Storage    Store at -20 degree C. Stable for 12 months from date of receipt.
 Other Notes    Small volumes of anti-KCNQ4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-KCNQ4 antibody

   Function: Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors.
Subunit Structure: Homotetramer. May form heteromultimers with KCNQ3. Interacts with HSP90AB1; promotes cell surface expression of KCNQ4 (PubMed:23431407).
Similarity: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.The A-domain tail carries the major determinants of channel assembly specificity. Its coiled-coil region is Four-stranded. Belongs to the potassium channel family. KQT (TC 1.A.1.15) subfamily. Kv7.4/KCNQ4 sub-subfamily.
 Applications Tested/Suitable for anti-KCNQ4 antibody   

Western Blot (WB), Immunohistochemisty (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC), ELISA (EIA)

 Application Notes for anti-KCNQ4 antibody    WB: 1:500-1:1000
IHC: 1:200
IF/ICC: 1:100-1:500
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 Immunohistochemistry (IHC) of anti-KCNQ4 antibody    MBS9605775 at 1/100 staining Human liver cancer tissue by IHC-P. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The sample was then blocked and incubated with the antibody for 1.5 hours at 22 degree C. An HRP conjugated goat anti-rabbit antibody was used as the secondary.
anti-KCNQ4 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescene (IF) of anti-KCNQ4 antibody    MBS9605775 staining HuvEc by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100, then blocked in 10% serum for 45 minutes at 25 degree C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37 degree C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) Ab, diluted at 1/600, was used as the secondary antibody.
anti-KCNQ4 antibody Immunofluorescene (IF) image
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 Western Blot (WB) of anti-KCNQ4 antibody    Western blot analysis of extracts from HuvEc cells, using KCNQ4 antibody.The lane on the left is treated with the antigen-specific peptide.
anti-KCNQ4 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for KCNQ4. It may not necessarily be applicable to this product.
 NCBI GI #    26638653
 NCBI GeneID    9132
 NCBI Accession #    NP_004691.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004700.3 [Other Products]
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 UniProt Primary Accession #    P56696 [Other Products]
 UniProt Secondary Accession #    O96025 [Other Products]
 UniProt Related Accession #    P56696 [Other Products]
 Molecular Weight    Observed: 80 kD
Predicted: 78 kDa
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 NCBI Official Full Name    potassium voltage-gated channel subfamily KQT member 4 isoform a
 NCBI Official Synonym Full Names    potassium voltage-gated channel subfamily Q member 4
 NCBI Official Symbol    KCNQ4 [Similar Products]
 NCBI Official Synonym Symbols   
DFNA2; KV7.4; DFNA2A
[Similar Products]
 NCBI Protein Information    potassium voltage-gated channel subfamily KQT member 4
 UniProt Protein Name    Potassium voltage-gated channel subfamily KQT member 4
 UniProt Synonym Protein Names   
KQT-like 4; Potassium channel subunit alpha KvLQT4; Voltage-gated potassium channel subunit Kv7.4
 Protein Family    Potassium voltage-gated channel subfamily
 UniProt Gene Name    KCNQ4 [Similar Products]
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 NCBI Summary for KCNQ4    The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for KCNQ4    Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors.
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 Research Articles on KCNQ4    1. KCNQ4 gene polymorphisms associated with susceptibility to noise-induced hearing loss.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KCNQ4 antibodyPathways associated with anti-KCNQ4 antibody
 Reference Product  PubMed Publications
 KCNQ3 antibody  >39 publications with KCNQ4 and KCNQ3
 Products by Pathway  Pathway Diagram
 Cholinergic Synapse Pathway antibodies  Cholinergic Synapse Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram
 Potassium Channels Pathway antibodies  Potassium Channels Pathway Diagram
 Voltage Gated Potassium Channels Pathway antibodies  Voltage Gated Potassium Channels Pathway Diagram
Diseases associated with anti-KCNQ4 antibodyOrgans/Tissues associated with anti-KCNQ4 antibody
 Disease Name  Pubmed Publications
 Hearing Loss Antibodies  >71 publications with KCNQ4 and Hearing Loss
 Nervous System Diseases Antibodies  >64 publications with KCNQ4 and Nervous System Diseases
 Ear Diseases Antibodies  >57 publications with KCNQ4 and Ear Diseases
 Vascular Diseases Antibodies  >3 publications with KCNQ4 and Vascular Diseases
 Disease Models, Animal Antibodies  >3 publications with KCNQ4 and Disease Models, Animal
 Hearing Loss, Noise-Induced Antibodies  >3 publications with KCNQ4 and Hearing Loss, Noise-Induced
 Inflammation Antibodies  >1 publications with KCNQ4 and Inflammation
 Peripheral Nervous System Diseases Antibodies  >1 publications with KCNQ4 and Peripheral Nervous System Diseases
 Headache Antibodies  >1 publications with KCNQ4 and Headache
 Kidney Diseases Antibodies  >1 publications with KCNQ4 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >27 publications with KCNQ4 and Brain
 Blood Antibodies  >13 publications with KCNQ4 and Blood
 Intestine Antibodies  >3 publications with KCNQ4 and Intestine
 Eye Antibodies  >3 publications with KCNQ4 and Eye
 Connective Tissue Antibodies  >1 publications with KCNQ4 and Connective Tissue
 Placenta Antibodies  >1 publications with KCNQ4 and Placenta
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