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anti-KDM2B antibody :: Goat KDM2B / FBXL10 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS241985
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

KDM2B / FBXL10, Polyclonal Antibody

 Also Known As   

Goat Polyclonal to Human KDM2B / FBXL10

 Product Synonym Names    Anti-KDM2B / FBXL10 Antibody (C-Terminus) IHC-plus; KDM2B; CXXC2; Fbl10; F-box/LRR-repeat protein 10; JHDM1B; F-box protein FBL10; FBXL10; Lysine-specific demethylase 2B; PCCX2; Protein JEMMA; Human KDM2B; FBXL10
 Product Gene Name   

anti-KDM2B antibody

[Similar Products]
 Product Synonym Gene Name    FBXL10 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    609078
 3D Structure    ModBase 3D Structure for Q8NHM5
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Bat, Gibbon, Bovine, Chicken, Dog, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Rabbit, Rat
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 Specificity    Human KDM2B / FBXL10. This antibody is expected to recognize isoform a (NP_115979.3) only.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
 Concentration    0.5 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide C-FGQVEEKLLQKLS from the C-terminus of human KDM2B / FBXL10 (NP_115979.3).
 Immunogen Type    Synthetic peptide
 Immunogen    KDM2B / FBXL10 antibody was raised against synthetic peptide C-FGQVEEKLLQKLS from the C-terminus of human KDM2B / FBXL10 (NP_115979.3). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Dog, Bovine, Bat, Hamster, Elephant, Panda, Horse, Rabbit, Turkey, Chicken, Platypus (100%); Xenopus (85%).
 Antigen Modification    C-Terminus
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 Preparation and Storage    Store at -20 degree C. Minimize freezing and thawing.
 Other Notes    Small volumes of anti-KDM2B antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-KDM2B antibody    Family: F-Box
 Applications Tested/Suitable for anti-KDM2B antibody   

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

 Application Notes for anti-KDM2B antibody    ELISA (1:32000), IHC-P (5 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-KDM2B antibody    Anti-KDM2B antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-KDM2B antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for KDM2B. It may not necessarily be applicable to this product.
 NCBI GI #    54112380
 NCBI GeneID    84678
 NCBI Accession #    NP_001005366.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001005366.1 [Other Products]
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 UniProt Primary Accession #    Q8NHM5 [Other Products]
 UniProt Secondary Accession #    Q8NCI2; Q96HC7; Q96SL0; Q96T03; Q9NS96; Q9UF75; A8MRS1 [Other Products]
 UniProt Related Accession #    Q8NHM5 [Other Products]
 Molecular Weight    144,769 Da
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 NCBI Official Full Name    lysine-specific demethylase 2B isoform b
 NCBI Official Synonym Full Names    lysine (K)-specific demethylase 2B
 NCBI Official Symbol    KDM2B [Similar Products]
 NCBI Official Synonym Symbols   
CXXC2; Fbl10; PCCX2; FBXL10; JHDM1B
[Similar Products]
 NCBI Protein Information    lysine-specific demethylase 2B; F-box protein FBL10; F-box/LRR-repeat protein 10; CXXC-type zinc finger protein 2; protein-containing CXXC domain 2; [Histone-H3]-lysine-36 demethylase 1B; F-box and leucine-rich repeat protein 10; jumonji C domain-containing histone demethylase 1B; jmjC domain-containing histone demethylation protein 1B; JEMMA (Jumonji domain, EMSY-interactor, methyltransferase motif) protein
 UniProt Protein Name    Lysine-specific demethylase 2B
 UniProt Synonym Protein Names   
CXXC-type zinc finger protein 2; F-box and leucine-rich repeat protein 10; F-box protein FBL10; F-box/LRR-repeat protein 10; JmjC domain-containing histone demethylation protein 1B; Jumonji domain-containing EMSY-interactor methyltransferase motif protein; Protein JEMMA; Protein-containing CXXC domain 2; [Histone-H3]-lysine-36 demethylase 1B
 Protein Family    Lysine-specific demethylase
 UniProt Gene Name    KDM2B [Similar Products]
 UniProt Synonym Gene Names    CXXC2; FBL10; FBXL10; JHDM1B; PCCX2; Protein JEMMA [Similar Products]
 UniProt Entry Name    KDM2B_HUMAN
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 NCBI Summary for KDM2B    This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]
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 UniProt Comments for KDM2B    FBXL10: Histone demethylase that demethylates 'Lys-4' and 'Lys- 36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Belongs to the JHDM1 histone demethylase family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 1.14.11.27; Oxidoreductase; Nucleolus; Demethylase; DNA-binding

Chromosomal Location of Human Ortholog: 12q24.31

Cellular Component: nucleoplasm; nucleolus; PcG protein complex; nucleus

Molecular Function: rRNA binding; protein binding; histone demethylase activity; DNA binding; zinc ion binding; histone demethylase activity (H3-K36 specific)

Biological Process: midbrain-hindbrain boundary morphogenesis; establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; fourth ventricle development; negative regulation of transcription from RNA polymerase II promoter; third ventricle development; initiation of neural tube closure; histone demethylation; midbrain development; forebrain development; spermatogenesis; embryonic camera-type eye morphogenesis; negative regulation of neuron apoptosis; lateral ventricle development; hindbrain development
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 Research Articles on KDM2B    1. NDY1/KDM2B functions as a master regulator of polycomb complexes and controls self-renewal of breast cancer stem cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KDM2B antibodyPathways associated with anti-KDM2B antibody
 Reference Product  PubMed Publications
 EZH2 antibody  >7 publications with KDM2B and EZH2
 PCGF1 antibody  >4 publications with KDM2B and PCGF1
 JUN antibody  >4 publications with KDM2B and JUN
 BCOR antibody  >3 publications with KDM2B and BCOR
 RNF2 antibody  >3 publications with KDM2B and RNF2
 SKP1 antibody  >3 publications with KDM2B and SKP1
 CUL1 antibody  >1 publications with KDM2B and CUL1
 Products by Pathway  Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 HDMs Demethylate Histones Pathway antibodies  HDMs Demethylate Histones Pathway Diagram
Diseases associated with anti-KDM2B antibodyOrgans/Tissues associated with anti-KDM2B antibody
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >2 publications with KDM2B and Adenocarcinoma
 Fibrosis Antibodies  >2 publications with KDM2B and Fibrosis
 Nervous System Diseases Antibodies  >2 publications with KDM2B and Nervous System Diseases
 Congenital Abnormalities Antibodies  >2 publications with KDM2B and Congenital Abnormalities
 Neural Tube Defects Antibodies  >1 publications with KDM2B and Neural Tube Defects
 Neurobehavioral Manifestations Antibodies  >1 publications with KDM2B and Neurobehavioral Manifestations
 Carcinoma, Hepatocellular Antibodies  >1 publications with KDM2B and Carcinoma, Hepatocellular
 Kidney Diseases Antibodies  >1 publications with KDM2B and Kidney Diseases
 Disease Models, Animal Antibodies  >1 publications with KDM2B and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >2 publications with KDM2B and Kidney
 Testis Antibodies  >2 publications with KDM2B and Testis
 Bone Antibodies  >2 publications with KDM2B and Bone
 Brain Antibodies  >2 publications with KDM2B and Brain
 Ascites Antibodies  >1 publications with KDM2B and Ascites
 Bladder Antibodies  >1 publications with KDM2B and Bladder
 Thymus Antibodies  >1 publications with KDM2B and Thymus
 Blood Antibodies  >1 publications with KDM2B and Blood
 Eye Antibodies  >1 publications with KDM2B and Eye
 Intestine Antibodies  >1 publications with KDM2B and Intestine
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