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anti-KDM4A antibody :: Rabbit anti-Human KDM4A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7045481
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

KDM4A, Polyclonal Antibody

★Popular Item★
 Also Known As   

KDM4A Antibody

 Product Synonym Names    Lysine-specific demethylase 4A; JmjC domain-containing histone demethylation protein 3A; Jumonji domain-containing protein 2A; KDM4A; JHDM3A; JMJD2; JMJD2A; KIAA0677
 Product Gene Name   

anti-KDM4A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    609764
 3D Structure    ModBase 3D Structure for O75164
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Species    Human
 Immunogen    Recombinant human Lysine-specific demethylase 4A protein
 Conjugate    Non-conjugated
 Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-54624
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-KDM4A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-KDM4A antibody

   Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.
 Applications Tested/Suitable for anti-KDM4A antibody   

ELISA (EIA), Immunohistochemistry (IHC), Immunofluorescence (IF)

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 Immunohistochemistry (IHC) of anti-KDM4A antibody    Immunohistochemistry of paraffin-embedded human testis tissue using MBS7045481 at dilution of 1:100
anti-KDM4A antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-KDM4A antibody    Immunohistochemistry of paraffin-embedded human brain tissue using MBS7045481 at dilution of 1:100
anti-KDM4A antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-KDM4A antibody    Immunofluorescent analysis of MCF7 cells using MBS7045481 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-KDM4A antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for KDM4A. It may not necessarily be applicable to this product.
 NCBI GI #    98986459
 NCBI GeneID    9682
 NCBI Accession #    NP_055478.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_014663.2 [Other Products]
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 UniProt Primary Accession #    O75164 [Other Products]
 UniProt Secondary Accession #    Q5VVB1 [Other Products]
 UniProt Related Accession #    O75164 [Other Products]
 Molecular Weight    54,697 Da
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 NCBI Official Full Name    lysine-specific demethylase 4A
 NCBI Official Synonym Full Names    lysine demethylase 4A
 NCBI Official Symbol    KDM4A [Similar Products]
 NCBI Official Synonym Symbols   
JMJD2; JHDM3A; JMJD2A; TDRD14A
[Similar Products]
 NCBI Protein Information    lysine-specific demethylase 4A
 UniProt Protein Name    Lysine-specific demethylase 4A
 UniProt Synonym Protein Names   
JmjC domain-containing histone demethylation protein 3A; Jumonji domain-containing protein 2A
 Protein Family    Lysine-specific demethylase
 UniProt Gene Name    KDM4A [Similar Products]
 UniProt Synonym Gene Names    JHDM3A; JMJD2; JMJD2A; KIAA0677 [Similar Products]
 UniProt Entry Name    KDM4A_HUMAN
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 NCBI Summary for KDM4A    This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein containing a JmjN domain, a JmjC domain, a JD2H domain, two TUDOR domains, and two PHD-type zinc fingers. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form, and as a transcriptional repressor. [provided by RefSeq, Apr 2009]
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 UniProt Comments for KDM4A    JMJD2A: Histone demethylase that specifically demethylates 'Lys- 9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. Interacts with histone deacetylase proteins HDAC1, HDAC2 and HDAC3. Interacts with RB and NCOR1. Interacts with HTLV-1 Tax protein. Ubiquitous. Belongs to the JHDM3 histone demethylase family.

Protein type: Transcription, coactivator/corepressor; Oxidoreductase; EC 1.14.11.-; Demethylase

Chromosomal Location of Human Ortholog: 1p34.1

Cellular Component: cytoplasm; nucleolus; nucleoplasm; nucleus

Molecular Function: histone demethylase activity; histone demethylase activity (H3-K36 specific); methylated histone residue binding; protein binding; ubiquitin protein ligase binding

Biological Process: histone demethylation; negative regulation of autophagy; negative regulation of transcription, DNA-dependent
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 Research Articles on KDM4A    1. Studies indicate that histone lysine demethylase (JmjC-KDM) KDM4A protein has been implicated in numerous cancers and cardiovascular diseases.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-KDM4A antibodyDiseases associated with anti-KDM4A antibody
 Products by Pathway  Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 DNA Double Strand Break Response Pathway antibodies  DNA Double Strand Break Response Pathway Diagram
 DNA Double-Strand Break Repair Pathway antibodies  DNA Double-Strand Break Repair Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 HDMs Demethylate Histones Pathway antibodies  HDMs Demethylate Histones Pathway Diagram
 Recruitment And ATM-mediated Phosphorylation Of Repair And Signaling Proteins At DNA Double Strand Breaks Pathway antibodies  Recruitment And ATM-mediated Phosphorylation Of Repair And Signaling Proteins At DNA Double Strand Breaks Pathway Diagram
 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >10 publications with KDM4A and Breast Neoplasms
 Prostatic Diseases Antibodies  >5 publications with KDM4A and Prostatic Diseases
 Lung Neoplasms Antibodies  >4 publications with KDM4A and Lung Neoplasms
 Cardiovascular Diseases Antibodies  >3 publications with KDM4A and Cardiovascular Diseases
 Inflammation Antibodies  >3 publications with KDM4A and Inflammation
 Neoplasms, Experimental Antibodies  >2 publications with KDM4A and Neoplasms, Experimental
 Lung Diseases Antibodies  >2 publications with KDM4A and Lung Diseases
 Hypertrophy Antibodies  >2 publications with KDM4A and Hypertrophy
 Adenocarcinoma Antibodies  >2 publications with KDM4A and Adenocarcinoma
 Embryo Loss Antibodies  >1 publications with KDM4A and Embryo Loss
Organs/Tissues associated with anti-KDM4A antibody
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >10 publications with KDM4A and Prostate
 Lung Antibodies  >7 publications with KDM4A and Lung
 Muscle Antibodies  >5 publications with KDM4A and Muscle
 Liver Antibodies  >3 publications with KDM4A and Liver
 Lymph Node Antibodies  >3 publications with KDM4A and Lymph Node
 Adipose Tissue Antibodies  >3 publications with KDM4A and Adipose Tissue
 Heart Antibodies  >3 publications with KDM4A and Heart
 Lymph Antibodies  >3 publications with KDM4A and Lymph
 Bladder Antibodies  >2 publications with KDM4A and Bladder
 Embryonic Tissue Antibodies  >2 publications with KDM4A and Embryonic Tissue
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