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anti-KERA antibody :: Rabbit anti-Human KERA Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS6012581 anti-KERA antibody
Unit / Price
0.2 mL  /  $550 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

KERA, Polyclonal Antibody

 Also Known As   

KERA, CT (KERA, SLRR2B, Keratocan, Keratan sulfate proteoglycan keratocan)

 Product Synonym Names    Anti -KERA, CT (KERA, SLRR2B, Keratocan, Keratan sulfate proteoglycan keratocan)
 Product Gene Name   

anti-KERA antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 12; NC_000012.11 (91444268..91452131, complement). Location: 12q22
 OMIM    217300
 3D Structure    ModBase 3D Structure for O60938
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Human
 Purity/Purification    Affinity Purified
Purified by Protein A affinity chromatography.
 Form/Format    Supplied as a liquid in PBS, pH 7.2, 0.09% sodium azide.
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 Immunogen    KERA antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 227-257 amino acids from the C-terminal region of human KERA.
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-KERA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-KERA antibody

   The protein encoded by this gene is a keratan sulfate proteoglycan that is involved in corneal transparency. Defects in this gene are a cause of autosomal recessive cornea plana 2 (CNA2).
 Product Categories/Family for anti-KERA antibody    Antibodies; Abs to Carbohydrates, Glycoproteins
 Applications Tested/Suitable for anti-KERA antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-KERA antibody    Suitable for use in Western Blot, ELISA
Dilution: ELISA: 1:1,000
Western Blot: 1:100-500
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NCBI/Uniprot data below describe general gene information for KERA. It may not necessarily be applicable to this product.
 NCBI GI #    5901992
 NCBI GeneID    11081
 NCBI Accession #    NP_008966.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_007035.3 [Other Products]
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 UniProt Primary Accession #    O60938 [Other Products]
 UniProt Related Accession #    O60938 [Other Products]
 Molecular Weight    40,509 Da [Similar Products]
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 NCBI Official Full Name    keratocan
 NCBI Official Synonym Full Names    keratocan
 NCBI Official Symbol    KERA [Similar Products]
 NCBI Official Synonym Symbols   
CNA2; SLRR2B
[Similar Products]
 NCBI Protein Information    keratocan; KTN; keratan sulfate proteoglycan keratocan
 UniProt Protein Name    Keratocan
 UniProt Synonym Protein Names   
Keratan sulfate proteoglycan keratocan
 Protein Family    Keratin
 UniProt Gene Name    KERA [Similar Products]
 UniProt Synonym Gene Names    SLRR2B; KTN [Similar Products]
 UniProt Entry Name    KERA_HUMAN
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 NCBI Summary for KERA    The protein encoded by this gene is a keratan sulfate proteoglycan that is involved in corneal transparency. Defects in this gene are a cause of autosomal recessive cornea plana 2 (CNA2).[provided by RefSeq, May 2010]
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 UniProt Comments for KERA    KERA: May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix. Defects in KERA are the cause of the autosomal recessive cornea plana 2 (CNA2). In CNA2, the forward convex curvature is flattened, leading to a decrease in refraction, reduced visual activity, extreme hyperopia (usually plus 10 d or more), hazy corneal limbus, opacities in the corneal parenchyma, and marked arcus senilis (often detected at an early age). CNA2 is a rare disorder with a worldwide distribution, but a high prevalence in the Finnish population. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 12q22

Cellular Component: lysosomal lumen; proteinaceous extracellular matrix; Golgi lumen; extracellular region

Biological Process: keratan sulfate metabolic process; visual perception; glycosaminoglycan metabolic process; keratan sulfate biosynthetic process; response to stimulus; carbohydrate metabolic process; pathogenesis; keratan sulfate catabolic process

Disease: Cornea Plana 2
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 Research Articles on KERA    1. Linkage and haplotype analyses identified 12q21.33 as a locus for posterior amorphous corneal dystrophy. However, no mutations were identified in the candidate genes (KERA, LUM, DCN, EPYC) within this region.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KERA antibodyPathways associated with anti-KERA antibody
 Reference Product  PubMed Publications
 LUM antibody  >9 publications with KERA and LUM
 OGN antibody  >4 publications with KERA and OGN
 B3GNT7 antibody  >2 publications with KERA and B3GNT7
 CHST6 antibody  >2 publications with KERA and CHST6
 PRELP antibody  >1 publications with KERA and PRELP
 FMOD antibody  >1 publications with KERA and FMOD
 ACAN antibody  >1 publications with KERA and ACAN
 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Glycosaminoglycan Metabolism Pathway antibodies  Glycosaminoglycan Metabolism Pathway Diagram
 Keratan Sulfate Biosynthesis Pathway antibodies  Keratan Sulfate Biosynthesis Pathway Diagram
 Keratan Sulfate Degradation Pathway antibodies  Keratan Sulfate Degradation Pathway Diagram
 Keratan Sulfate/keratin Metabolism Pathway antibodies  Keratan Sulfate/keratin Metabolism Pathway Diagram
 MPS I - Hurler Syndrome Pathway antibodies  MPS I - Hurler Syndrome Pathway Diagram
 MPS II - Hunter Syndrome Pathway antibodies  MPS II - Hunter Syndrome Pathway Diagram
 MPS IIIA - Sanfilippo Syndrome A Pathway antibodies  MPS IIIA - Sanfilippo Syndrome A Pathway Diagram
 MPS IIIB - Sanfilippo Syndrome B Pathway antibodies  MPS IIIB - Sanfilippo Syndrome B Pathway Diagram
 MPS IIIC - Sanfilippo Syndrome C Pathway antibodies  MPS IIIC - Sanfilippo Syndrome C Pathway Diagram
Diseases associated with anti-KERA antibodyOrgans/Tissues associated with anti-KERA antibody
 Disease Name  Pubmed Publications
 Liver Diseases Antibodies  >13 publications with KERA and Liver Diseases
 Necrosis Antibodies  >7 publications with KERA and Necrosis
 Eye Abnormalities Antibodies  >7 publications with KERA and Eye Abnormalities
 Disease Models, Animal Antibodies  >6 publications with KERA and Disease Models, Animal
 Cornea Plana 2 Antibodies  >6 publications with KERA and Cornea Plana 2
 Nervous System Diseases Antibodies  >3 publications with KERA and Nervous System Diseases
 Poisoning Antibodies  >2 publications with KERA and Poisoning
 Drug-Induced Liver Injury Antibodies  >2 publications with KERA and Drug-Induced Liver Injury
 Atrophy Antibodies  >2 publications with KERA and Atrophy
 Fatty Liver Antibodies  >2 publications with KERA and Fatty Liver
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >80 publications with KERA and Eye
 Embryonic Tissue Antibodies  >11 publications with KERA and Embryonic Tissue
 Intestine Antibodies  >1 publications with KERA and Intestine
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