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anti-KIRREL3 antibody :: Rabbit KIRREL3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS153422
Western Blot (WB)
Unit / Price
0.02 mg  /  $140 +1 FREE 8GB USB
0.1 mg  /  $355 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

KIRREL3, Polyclonal Antibody

 Also Known As   

KIRREL3 Antibody

 Product Synonym Names    Kin of irregular chiasm-like protein 3; Kin of IRRE-like protein 3; MRD4; KIRRE; NEPH2; PRO4502; Nephrin-like protein 2; kin of IRRE like 3 (Drosophila)
 Product Gene Name   

anti-KIRREL3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 612581
 3D Structure    ModBase 3D Structure for Q8IZU9
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    KIRREL3 antibody is human, mouse and rat reactive. At least two isoforms are known to exist; this antibody will detect both isoforms. KIRREL3 antibody is predicted to not cross-react with other members of the KIRREL protein family.
 Purity/Purification    KIRREL3 antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    KIRREL3 antibody was raised against a 19 amino acid peptide near the amino terminus of human KIRREL3.
 Buffer    KIRREL3 antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    KIRREL3 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year.
 Other Notes    Small volumes of anti-KIRREL3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-KIRREL3 antibody

   KIRREL3, also known as nephrin-like protein 2, is a type I transmembrane protein belonging to a family of three podocin interacting proteins and the immunoglobulin superfamily (1). KIRREL3 is involved in the regulation of both glomerular and neural development (2), and more specifically, the nucleogenesis of the pontine nuclei in the developing hindbrain (3). KIRREL3 has also been shown to interact with the synaptic scaffold protein calmodulin-associated serine/threonine kinase (CASK) in neuronal cells (4).
 Applications Tested/Suitable for anti-KIRREL3 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-KIRREL3 antibody    KIRREL3 antibody can be used for detection of KIRREL3 by Western blot at 1 - 2 mug/ml. Antibody can also be used for immunohistochemistry starting at 5 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-KIRREL3 antibody    Western blot analysis of KIRREL3 in mouse kidney tissue lysate with KIRREL3 antibody at (A) 1 and (B) 2 μg/ml.
anti-KIRREL3 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for KIRREL3. It may not necessarily be applicable to this product.
 NCBI GI #    26006461
 NCBI GeneID    84623
 NCBI Accession #    NP_115920 [Other Products]
 NCBI GenBank Nucleotide #    NM_032531.3 [Other Products]
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 UniProt Primary Accession #    Q8IZU9 [Other Products]
 UniProt Secondary Accession #    Q3MIJ7; Q6UWJ9; Q6UWL5; Q96JG0 [Other Products]
 UniProt Related Accession #    Q8IZU9 [Other Products]
 Molecular Weight    Predicted: 64; 84 kDa

Observed: 60 kDa
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 NCBI Official Full Name    kin of IRRE-like protein 3 isoform 1
 NCBI Official Synonym Full Names    kin of IRRE like 3 (Drosophila)
 NCBI Official Symbol    KIRREL3 [Similar Products]
 NCBI Official Synonym Symbols   
MRD4; KIRRE; NEPH2; PRO4502
[Similar Products]
 NCBI Protein Information    kin of IRRE-like protein 3; nephrin-like 2; nephrin-like protein 2; kin of irregular chiasm-like protein 3
 UniProt Protein Name    Kin of IRRE-like protein 3
 UniProt Synonym Protein Names   
Kin of irregular chiasm-like protein 3; Nephrin-like protein 2
 Protein Family    Kin of IRRE-like protein
 UniProt Gene Name    KIRREL3 [Similar Products]
 UniProt Synonym Gene Names    KIAA1867; NEPH2 [Similar Products]
 UniProt Entry Name    KIRR3_HUMAN
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 NCBI Summary for KIRREL3    The protein encoded by this gene is a member of the nephrin-like protein family. These proteins are expressed in fetal and adult brain, and also in podocytes of kidney glomeruli. The cytoplasmic domains of these proteins interact with the C-terminus of podocin, also expressed in the podocytes, cells involved in ensuring size- and charge-selective ultrafiltration. Mutations in this gene are associated with mental retardation autosomal dominant type 4 (MRD4). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
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 UniProt Comments for KIRREL3    KIRREL3: Could be involved in the hematopoietic supportive capacity of stroma cells. A chromosomal aberration involving KIRREL3 and CDH15 is found in a patient with severe mental retardation and dysmorphic facial features. Translocation t(11;16)(q24.2;q24). Defects in KIRREL3 are the cause of mental retardation autosomal dominant type 4 (MRD4). Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Belongs to the immunoglobulin superfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q24

Cellular Component: axon; plasma membrane; extracellular region; integral to membrane; dendritic shaft

Molecular Function: protein binding

Biological Process: pontine nucleus development; neuron migration; hemopoiesis; neurite morphogenesis

Disease: Mental Retardation, Autosomal Dominant 4
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 Research Articles on KIRREL3    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KIRREL3 antibodyPathways associated with anti-KIRREL3 antibody
 Reference Product  PubMed Publications
 KIRREL2 antibody  >5 publications with KIRREL3 and KIRREL2
 CDH15 antibody  >1 publications with KIRREL3 and CDH15
 CASK antibody  >1 publications with KIRREL3 and CASK
 NPHS2 antibody  >1 publications with KIRREL3 and NPHS2
 Products by Pathway  Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Nephrin Interactions Pathway antibodies  Nephrin Interactions Pathway Diagram
Diseases associated with anti-KIRREL3 antibodyOrgans/Tissues associated with anti-KIRREL3 antibody
 Disease Name  Pubmed Publications
 Mental Disorders Antibodies  >4 publications with KIRREL3 and Mental Disorders
 Growth Disorders Antibodies  >2 publications with KIRREL3 and Growth Disorders
 Abnormalities, Multiple Antibodies  >1 publications with KIRREL3 and Abnormalities, Multiple
 Kidney Diseases Antibodies  >1 publications with KIRREL3 and Kidney Diseases
 Necrosis Antibodies  >1 publications with KIRREL3 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >13 publications with KIRREL3 and Brain
 Kidney Antibodies  >4 publications with KIRREL3 and Kidney
 Eye Antibodies  >2 publications with KIRREL3 and Eye
 Heart Antibodies  >2 publications with KIRREL3 and Heart
 Embryonic Tissue Antibodies  >2 publications with KIRREL3 and Embryonic Tissue
 Liver Antibodies  >1 publications with KIRREL3 and Liver
 Lung Antibodies  >1 publications with KIRREL3 and Lung
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