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anti-KLK2 antibody :: Rabbit anti-Human, Mouse KLK2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2521782
Unit / Price
0.06 mL  /  $195 +1 FREE 8GB USB
0.12 mL  /  $270 +1 FREE 8GB USB
0.2 mL  /  $435 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

KLK2, Polyclonal Antibody

★Popular Item★
 Also Known As   

KLK2 Antibody

 Product Synonym Names    KLK2A2; MGC12201; hK2
 Product Gene Name   

anti-KLK2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    147960
 3D Structure    ModBase 3D Structure for P20151
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    Antigen affinity purification
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 Immunogen    Fusion protein of KLK2
 Calculated Molecular Weight    28kd
 Observed Molecular Weight    29kD
 Buffer    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-20368
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-KLK2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-KLK2 antibody

   KLK2(Kallikrein-2) is also named as hGK-l and belongs to the Kallikrein subfamily. It plays a role in prostate cancer susceptibility and this role may be realized at least in part by the induction of increases in its production. It also may mediate tumor growth and invasion by participating in proteolytic cascades. This protein has 4 isoforms produced by alternative splicing with the molecular weight of 29 kDa, 25 kDa, 18 kDa and 17 kDa.
 Applications Tested/Suitable for anti-KLK2 antibody   

ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

 Application Notes for anti-KLK2 antibody    WB: 1:200-1:1000
IHC: 1:20-1:200
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 SDS-PAGE of anti-KLK2 antibody    mouse pancreas tissue were subjected to SDS PAGE followed by western blot with KLK2 Antibndy at dilution of I :300
anti-KLK2 antibody SDS-PAGE image
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 Immunohistochemistry of anti-KLK2 antibody    Immunohistochemical of paraffin-embedded human prostate cancer using KLK2 antibody at dilution of 1:100 (under lOx lens)
anti-KLK2 antibody Immunohistochemistry (IHC) image
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NCBI/Uniprot data below describe general gene information for KLK2. It may not necessarily be applicable to this product.
 NCBI GI #    368710110
 NCBI GeneID    3817
 NCBI Accession #    NP_001243009.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001256080.1 [Other Products]
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 UniProt Primary Accession #    P20151 [Other Products]
 UniProt Secondary Accession #    Q15946; Q9UJZ9; B4DU93; B4DUB0; F5H8L3 [Other Products]
 UniProt Related Accession #    P20151 [Other Products]
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 NCBI Official Full Name    kallikrein-2 isoform 3
 NCBI Official Synonym Full Names    kallikrein-related peptidase 2
 NCBI Official Symbol    KLK2 [Similar Products]
 NCBI Official Synonym Symbols   
hK2; hGK-1; KLK2A2
[Similar Products]
 NCBI Protein Information    kallikrein-2; glandular kallikrein 2; glandular kallikrein-1; kallikrein 2, prostatic; tissue kallikrein-2
 UniProt Protein Name    Kallikrein-2
 UniProt Synonym Protein Names   
Glandular kallikrein-1; hGK-1; Tissue kallikrein-2
 Protein Family    Kallikrein
 UniProt Gene Name    KLK2 [Similar Products]
 UniProt Synonym Gene Names    hGK-1 [Similar Products]
 UniProt Entry Name    KLK2_HUMAN
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 NCBI Summary for KLK2    This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Jan 2012]
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 UniProt Comments for KLK2    KLK2: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Belongs to the peptidase S1 family. Kallikrein subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.21.35; Protease

Chromosomal Location of Human Ortholog: 19q13.41

Cellular Component: extracellular region

Molecular Function: serine-type endopeptidase activity

Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; proteolysis
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 Research Articles on KLK2    1. Predictions based on levels of four kallikrein markers, including KLK2, in blood distinguish between pathologically insignificant and aggressive disease after radical prostatectomy with good accuracy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KLK2 antibodyPathways associated with anti-KLK2 antibody
 Reference Product  PubMed Publications
 SRC antibody  >1 publications with KLK2 and SRC
 CARM1 antibody  >1 publications with KLK2 and CARM1
 NCOA2 antibody  >1 publications with KLK2 and NCOA2
 Products by Pathway  Pathway Diagram
 Activation Of Matrix Metalloproteinases Pathway antibodies  Activation Of Matrix Metalloproteinases Pathway Diagram
 Coregulation Of Androgen Receptor Activity Pathway antibodies  Coregulation Of Androgen Receptor Activity Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Endocrine And Other Factor-regulated Calcium Reabsorption Pathway antibodies  Endocrine And Other Factor-regulated Calcium Reabsorption Pathway Diagram
 Endocrine And Other Factor-regulated Calcium Reabsorption Pathway antibodies  Endocrine And Other Factor-regulated Calcium Reabsorption Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Prostate Cancer Pathway antibodies  Prostate Cancer Pathway Diagram
 Regulation Of Androgen Receptor Activity Pathway antibodies  Regulation Of Androgen Receptor Activity Pathway Diagram
 Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway antibodies  Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway Diagram
Diseases associated with anti-KLK2 antibodyOrgans/Tissues associated with anti-KLK2 antibody
 Disease Name  Pubmed Publications
 Prostatic Neoplasms Antibodies  >62 publications with KLK2 and Prostatic Neoplasms
 Breast Neoplasms Antibodies  >10 publications with KLK2 and Breast Neoplasms
 Hyperplasia Antibodies  >9 publications with KLK2 and Hyperplasia
 Prostatic Hyperplasia Antibodies  >8 publications with KLK2 and Prostatic Hyperplasia
 Adenocarcinoma Antibodies  >7 publications with KLK2 and Adenocarcinoma
 Ovarian Neoplasms Antibodies  >6 publications with KLK2 and Ovarian Neoplasms
 Neoplasms, Experimental Antibodies  >4 publications with KLK2 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >3 publications with KLK2 and Lung Neoplasms
 Neovascularization, Pathologic Antibodies  >2 publications with KLK2 and Neovascularization, Pathologic
 Kidney Diseases Antibodies  >2 publications with KLK2 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >105 publications with KLK2 and Prostate
 Lung Antibodies  >4 publications with KLK2 and Lung
 Testis Antibodies  >3 publications with KLK2 and Testis
 Bone Antibodies  >3 publications with KLK2 and Bone
 Bone Marrow Antibodies  >1 publications with KLK2 and Bone Marrow
 Muscle Antibodies  >1 publications with KLK2 and Muscle
 Nerve Antibodies  >1 publications with KLK2 and Nerve
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