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anti-KLK6 antibody :: Goat KLK6 / Kallikrein 6 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS248421
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

KLK6 / Kallikrein 6, Polyclonal Antibody

 Also Known As   

Goat Polyclonal to Human KLK6 / Kallikrein 6

 Product Synonym Names    Anti-KLK6 / Kallikrein 6 Antibody (aa145-156) IHC-plus; KLK6; Bssp; HK6; Kallikrein-related peptidase 6; Kallikrein 6 (neurosin; zyme); Neurosin; Protease; serine; 18; Protease M; PRSS9; Serine protease 9; Zyme; Serine protease 18; Kallikrein 6; Kallikrein-6; PRSS18; SP59; Human KLK6; Kallikrein 6
 Product Gene Name   

anti-KLK6 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602652
 3D Structure    ModBase 3D Structure for Q92876
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Human, Monkey
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 Specificity    Human KLK6 / Kallikrein 6. This antibody is expected to recognize both reported isoforms (NP_002765.1; NP_001012983.1). Reported variants represent identical protein: NP_002765.1, NP_001012982.1.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    Tris saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
 Concentration    0.5 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide C-KTADGDFPDTIQ from an internal region of human KLK6 / Kallikrein 6 (NP_002765.1; NP_001012983.1). Percent identity by BLAST analysis: Human, Gorilla, Monkey (100%); Elephant (92%); Ferret, Panda, Horse (83%); Mouse (75%); Rat (67%).
 Immunogen Type    Synthetic peptide
 Immunogen    KLK6 / Kallikrein 6 antibody was raised against synthetic peptide C-KTADGDFPDTIQ from an internal region of human KLK6 / Kallikrein 6 (NP_002765.1; NP_001012983.1). Percent identity by BLAST analysis: Human, Gorilla, Monkey (100%); Elephant (92%); Ferret, Panda, Horse (83%); Mouse (75%); Rat (67%).
 Antigen Modification    aa145-156
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 Preparation and Storage    Store at -20 degree C. Minimize freezing and thawing.
 Other Notes    Small volumes of anti-KLK6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-KLK6 antibody

   Human kallikrein 6 (hK6) is a trypsin-like serine protease, member of the human kallikrein gene family. Studies suggested a potential involvement of hK6 in the development and progression of Alzheimer's disease and ovarian cancer.
 Product Categories/Family for anti-KLK6 antibody    Family: Protease
Subfamily: Serine S1
 Applications Tested/Suitable for anti-KLK6 antibody   

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

 Application Notes for anti-KLK6 antibody    ELISA (1:128000), IHC-P (5 ug/ml)
Usage: Peptide ELISA: antibody detection limit dilution 1:128000. Western blot: Preliminary experiments gave an approx 50kD band in Human Ovary lysates after 0.5 ug/ml antibody staining. Please note that currently we cannot find an explanation in the litera...
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 Immunohistochemistry (IHC) of anti-KLK6 antibody    Anti-KLK6 / Kallikrein 6 antibody IHC staining of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-KLK6 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-KLK6 antibody    Anti-KLK6 / Kallikrein 6 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-KLK6 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for KLK6. It may not necessarily be applicable to this product.
 NCBI GI #    4506155
 NCBI GeneID    5653
 NCBI Accession #    NP_002765.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002774.3 [Other Products]
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 UniProt Primary Accession #    Q92876 [Other Products]
 UniProt Secondary Accession #    Q6H301; A6NJA1; A8MW09 [Other Products]
 UniProt Related Accession #    Q92876 [Other Products]
 Molecular Weight    4,333 Da
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 NCBI Official Full Name    kallikrein-6 isoform A preproprotein
 NCBI Official Synonym Full Names    kallikrein-related peptidase 6
 NCBI Official Symbol    KLK6 [Similar Products]
 NCBI Official Synonym Symbols   
hK6; Bssp; Klk7; SP59; PRSS9; PRSS18
[Similar Products]
 NCBI Protein Information    kallikrein-6; zyme; neurosin; protease M; serine protease 9; serine protease 18
 UniProt Protein Name    Kallikrein-6
 UniProt Synonym Protein Names   
Neurosin; Protease M; SP59; Serine protease 18; Serine protease 9; Zyme
 Protein Family    Kallikrein
 UniProt Gene Name    KLK6 [Similar Products]
 UniProt Synonym Gene Names    PRSS18; PRSS9 [Similar Products]
 UniProt Entry Name    KLK6_HUMAN
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 NCBI Summary for KLK6    Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for KLK6    KLK6: Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis. Belongs to the peptidase S1 family. Kallikrein subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Protease; Nucleolus; Secreted, signal peptide; EC 3.4.21.-

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: microtubule cytoskeleton; nucleoplasm; extracellular space; nuclear membrane; intercellular bridge; mitochondrion; endoplasmic reticulum; cytoplasm; nucleolus; extracellular region

Molecular Function: protein binding; serine-type endopeptidase activity

Biological Process: myelination; protein autoprocessing; collagen catabolic process; central nervous system development; amyloid precursor protein metabolic process; tissue regeneration; positive regulation of G-protein coupled receptor protein signaling pathway; regulation of cell differentiation; response to wounding; hormone metabolic process; protein processing; proteolysis
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 Research Articles on KLK6    1. KLK6 mRNA expression could be considered as an independent, unfavorable molecular prognostic biomarker in colorectal adenocarcinoma, with additional prognostic value in patients without regional or distant metastases
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KLK6 antibodyPathways associated with anti-KLK6 antibody
 Reference Product  PubMed Publications
 SERPINC1 antibody  >1 publications with KLK6 and SERPINC1
 APP antibody  >1 publications with KLK6 and APP
 SNCA antibody  >1 publications with KLK6 and SNCA
 Products by Pathway  Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
Diseases associated with anti-KLK6 antibodyOrgans/Tissues associated with anti-KLK6 antibody
 Disease Name  Pubmed Publications
 Ovarian Neoplasms Antibodies  >39 publications with KLK6 and Ovarian Neoplasms
 Carcinoma Antibodies  >33 publications with KLK6 and Carcinoma
 Nervous System Diseases Antibodies  >28 publications with KLK6 and Nervous System Diseases
 Brain Diseases Antibodies  >19 publications with KLK6 and Brain Diseases
 Breast Neoplasms Antibodies  >17 publications with KLK6 and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >12 publications with KLK6 and Neoplasm Metastasis
 Disease Models, Animal Antibodies  >11 publications with KLK6 and Disease Models, Animal
 Inflammation Antibodies  >10 publications with KLK6 and Inflammation
 Neoplasms, Experimental Antibodies  >7 publications with KLK6 and Neoplasms, Experimental
 Lung Neoplasms Antibodies  >4 publications with KLK6 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >34 publications with KLK6 and Brain
 Ascites Antibodies  >13 publications with KLK6 and Ascites
 Spinal Cord Antibodies  >9 publications with KLK6 and Spinal Cord
 Ovary Antibodies  >8 publications with KLK6 and Ovary
 Lymph Node Antibodies  >7 publications with KLK6 and Lymph Node
 Lung Antibodies  >6 publications with KLK6 and Lung
 Kidney Antibodies  >5 publications with KLK6 and Kidney
 Stomach Antibodies  >5 publications with KLK6 and Stomach
 Mammary Gland Antibodies  >4 publications with KLK6 and Mammary Gland
 Pancreas Antibodies  >4 publications with KLK6 and Pancreas
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