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anti-KLKB1 antibody :: Rabbit KLKB1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7048528
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

KLKB1, Polyclonal Antibody

★Popular Item★
 Also Known As   

KLKB1 Antibody

 Product Synonym Names    Plasma kallikrein; Fletcher factor; Kininogenin; Plasma prekallikrein; PKK; Plasma kallikrein heavy chain; Plasma kallikrein light chain; KLKB1; KLK3
 Product Gene Name   

anti-KLKB1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    M13143 mRNA
 3D Structure    ModBase 3D Structure for P03952
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant Human Plasma kallikrein protein (503-612AA)
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, pH 7.4
 Conjugation    Non-conjugated
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-133915 / sc-18658 / sc-18659 / sc-25799
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-KLKB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-KLKB1 antibody

   The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.
 Applications Tested/Suitable for anti-KLKB1 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-KLKB1 antibody    WB: 1: 500-1: 5000
IHC: 1: 20-1: 200
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 Western Blot (WB) of anti-KLKB1 antibody    Western Blot
Positive WB detected in: HepG2 whole cell lysate,Rat liver tissue,Rat brain tissue,Mouse heart tissue
All lanes: KLKB1 antibody at 2.5ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 72 KDa
Observed band size: 72 KDa

anti-KLKB1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-KLKB1 antibody    Immunohistochemistry of paraffin-embedded human liver tissue using MBS7048528 at dilution of 1:100
anti-KLKB1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for KLKB1. It may not necessarily be applicable to this product.
 NCBI GI #    78191798
 NCBI GeneID    3818
 NCBI Accession #    NP_000883.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000892.4 [Other Products]
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 UniProt Primary Accession #    P03952 [Other Products]
 UniProt Secondary Accession #    Q17RE8; Q17RE9; Q4W5C3; A6NH96; B2R8H9 [Other Products]
 UniProt Related Accession #    P03952 [Other Products]
 Molecular Weight    71,370 Da
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 NCBI Official Full Name    plasma kallikrein isoform 1 preproprotein
 NCBI Official Synonym Full Names    kallikrein B1
 NCBI Official Symbol    KLKB1 [Similar Products]
 NCBI Official Synonym Symbols   
PKK; PPK; KLK3; PKKD
[Similar Products]
 NCBI Protein Information    plasma kallikrein
 UniProt Protein Name    Plasma kallikrein
 UniProt Synonym Protein Names   
Fletcher factor; Kininogenin; Plasma prekallikrein; PKK
 Protein Family    Plasma kallikrein
 UniProt Gene Name    KLKB1 [Similar Products]
 UniProt Synonym Gene Names    KLK3; PKK [Similar Products]
 UniProt Entry Name    KLKB1_HUMAN
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 NCBI Summary for KLKB1    This gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
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 UniProt Comments for KLKB1    KLKB1: The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency); also known as Fletcher factor deficiency. This disorder is a blood coagulation defect. Belongs to the peptidase S1 family. Plasma kallikrein subfamily.

Protein type: EC 3.4.21.34; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q35

Cellular Component: extracellular region; extracellular space; plasma membrane

Molecular Function: protein binding; serine-type endopeptidase activity

Biological Process: blood coagulation, intrinsic pathway; extracellular matrix disassembly; Factor XII activation; plasminogen activation; positive regulation of fibrinolysis; proteolysis; zymogen activation

Disease: Prekallikrein Deficiency
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 Research Articles on KLKB1    1. KLKB1 mRNA expression is a putative molecular biomarker in chronic lymphocytic leukemia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KLKB1 antibodyPathways associated with anti-KLKB1 antibody
 Reference Product  PubMed Publications
 F11 antibody  >8 publications with KLKB1 and F11
 F12 antibody  >7 publications with KLKB1 and F12
 KNG1 antibody  >2 publications with KLKB1 and KNG1
 PRCP antibody  >1 publications with KLKB1 and PRCP
 Products by Pathway  Pathway Diagram
 Activation Of Matrix Metalloproteinases Pathway antibodies  Activation Of Matrix Metalloproteinases Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Complement And Coagulation Cascades Pathway antibodies  Complement And Coagulation Cascades Pathway Diagram
 Degradation Of The Extracellular Matrix Pathway antibodies  Degradation Of The Extracellular Matrix Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Intrinsic Pathway Of Fibrin Clot Formation antibodies  Intrinsic Pathway Of Fibrin Clot Formation Diagram
Diseases associated with anti-KLKB1 antibodyOrgans/Tissues associated with anti-KLKB1 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >15 publications with KLKB1 and Cardiovascular Diseases
 Thrombosis Antibodies  >8 publications with KLKB1 and Thrombosis
 Hypertension Antibodies  >6 publications with KLKB1 and Hypertension
 Kidney Diseases Antibodies  >3 publications with KLKB1 and Kidney Diseases
 Inflammation Antibodies  >3 publications with KLKB1 and Inflammation
 Edema Antibodies  >2 publications with KLKB1 and Edema
 Mental Disorders Antibodies  >2 publications with KLKB1 and Mental Disorders
 Lung Neoplasms Antibodies  >2 publications with KLKB1 and Lung Neoplasms
 Pulmonary Embolism Antibodies  >2 publications with KLKB1 and Pulmonary Embolism
 Heart Diseases Antibodies  >1 publications with KLKB1 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >7 publications with KLKB1 and Kidney
 Heart Antibodies  >4 publications with KLKB1 and Heart
 Brain Antibodies  >3 publications with KLKB1 and Brain
 Eye Antibodies  >2 publications with KLKB1 and Eye
 Liver Antibodies  >2 publications with KLKB1 and Liver
 Connective Tissue Antibodies  >1 publications with KLKB1 and Connective Tissue
 Mammary Gland Antibodies  >1 publications with KLKB1 and Mammary Gland
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