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anti-KPNA1 antibody :: Rabbit KPNA1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS126781
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

KPNA1, Polyclonal Antibody

★Popular Item★
 Also Known As   

KPNA1 Polyclonal Antibody

 Product Synonym Names    RCH2; SRP1; IPOA5; NPI-1
 Product Gene Name   

anti-KPNA1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600686
 3D Structure    ModBase 3D Structure for P52294
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human KPNA1
 Calculated Molecular Weight    60kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-KPNA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-KPNA1 antibody

   The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin ligase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
 Product Categories/Family for anti-KPNA1 antibody    Polyclonal
 Applications Tested/Suitable for anti-KPNA1 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-KPNA1 antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
IF: 1:50 - 1:200
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 Western Blot (WB) of anti-KPNA1 antibody    Western blot analysis of extracts of various cell lines, using KPNA1 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
anti-KPNA1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-KPNA1 antibody    Immunohistochemistry of paraffin-embedded human lung cancer using KPNA1 antibody at dilution of 1:100 (40x lens).
anti-KPNA1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-KPNA1 antibody    Immunohistochemistry of paraffin-embedded human esophagus using KPNA1 antibody at dilution of 1:100 (40x lens).
anti-KPNA1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-KPNA1 antibody    Immunofluorescence analysis of A549 cells using KPNA1 antibody.
anti-KPNA1 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for KPNA1. It may not necessarily be applicable to this product.
 NCBI GI #    296439328
 NCBI GeneID    3836
 NCBI Accession #    P52294.3 [Other Products]
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 UniProt Primary Accession #    P52294 [Other Products]
 UniProt Secondary Accession #    Q6IBQ9; Q9BQ56; D3DN93 [Other Products]
 UniProt Related Accession #    P52294 [Other Products]
 Molecular Weight    538
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 NCBI Official Full Name    Importin subunit alpha-5
 NCBI Official Synonym Full Names    karyopherin alpha 1 (importin alpha 5)
 NCBI Official Symbol    KPNA1 [Similar Products]
 NCBI Official Synonym Symbols   
RCH2; SRP1; IPOA5; NPI-1
[Similar Products]
 NCBI Protein Information    importin subunit alpha-5; SRP1-beta; importin alpha 5; importin-alpha-S1; RAG cohort protein 2; importin subunit alpha-1; nucleoprotein interactor 1; karyopherin subunit alpha-1; recombination activating gene cohort 2
 UniProt Protein Name    Importin subunit alpha-5
 UniProt Synonym Protein Names   
Karyopherin subunit alpha-1; Nucleoprotein interactor 1; NPI-1; RAG cohort protein 2; SRP1-betaImportin subunit alpha-5, N-terminally processed
 UniProt Gene Name    KPNA1 [Similar Products]
 UniProt Synonym Gene Names    RCH2; NPI-1 [Similar Products]
 UniProt Entry Name    IMA5_HUMAN
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 NCBI Summary for KPNA1    The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. This protein interacts with the recombination activating gene 1 (RAG1) protein and is a putative substrate of the RAG1 ubiquitin ligase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
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 UniProt Comments for KPNA1    KPNA1: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS. Belongs to the importin alpha family.

Protein type: Nuclear import; Karyopherin; Adaptor/scaffold

Chromosomal Location of Human Ortholog: 3q21

Cellular Component: nucleoplasm; dendrite; cytoplasm; nuclear pore; cytosol; nucleus

Molecular Function: protein binding; nuclear localization sequence binding; protein transporter activity

Biological Process: viral reproduction; positive regulation of protein import into nucleus; apoptosis; regulation of DNA recombination; cytokine and chemokine mediated signaling pathway; DNA fragmentation during apoptosis; NLS-bearing substrate import into nucleus; viral infectious cycle; cell structure disassembly during apoptosis
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 Research Articles on KPNA1    1. miR-223 downregulation promotes glomerular endothelial cell activation by upregulating importin alpha4 and alpha5 in IgA nephropathy
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KPNA1 antibodyPathways associated with anti-KPNA1 antibody
 Reference Product  PubMed Publications
 KPNB1 antibody  >5 publications with KPNA1 and KPNB1
 RAG1 antibody  >2 publications with KPNA1 and RAG1
 NUP50 antibody  >1 publications with KPNA1 and NUP50
 Products by Pathway  Pathway Diagram
 Activation Of DNA Fragmentation Factor Pathway antibodies  Activation Of DNA Fragmentation Factor Pathway Diagram
 Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies  Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Induced DNA Fragmentation Pathway antibodies  Apoptosis Induced DNA Fragmentation Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Class I PI3K Signaling Events Mediated By Akt Pathway antibodies  Class I PI3K Signaling Events Mediated By Akt Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Early Phase Of HIV Life Cycle Pathway antibodies  Early Phase Of HIV Life Cycle Pathway Diagram
 HIV Infection Pathway antibodies  HIV Infection Pathway Diagram
Diseases associated with anti-KPNA1 antibodyOrgans/Tissues associated with anti-KPNA1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >2 publications with KPNA1 and Inflammation
 Nervous System Diseases Antibodies  >1 publications with KPNA1 and Nervous System Diseases
 Brain Diseases Antibodies  >1 publications with KPNA1 and Brain Diseases
 Kidney Diseases Antibodies  >1 publications with KPNA1 and Kidney Diseases
 Nephritis Antibodies  >1 publications with KPNA1 and Nephritis
 Schizophrenia Antibodies  >1 publications with KPNA1 and Schizophrenia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4 publications with KPNA1 and Blood
 Brain Antibodies  >4 publications with KPNA1 and Brain
 Muscle Antibodies  >2 publications with KPNA1 and Muscle
 Bone Marrow Antibodies  >1 publications with KPNA1 and Bone Marrow
 Kidney Antibodies  >1 publications with KPNA1 and Kidney
 Lymph Antibodies  >1 publications with KPNA1 and Lymph
 Uterus Antibodies  >1 publications with KPNA1 and Uterus
 Skin Antibodies  >1 publications with KPNA1 and Skin
 Prostate Antibodies  >1 publications with KPNA1 and Prostate
 Mouth Antibodies  >1 publications with KPNA1 and Mouth
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