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anti-KPNA2 antibody :: Goat KPNA2/IPOA1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421014
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

KPNA2/IPOA1, Polyclonal Antibody

 Also Known As   

Goat anti-KPNA2/IPOA1 Antibody

 Product Synonym Names    Goat Anti-KPNA2 / IPOA1, Biotinylated Antibody; KPNA2; IPOA1 QIP2; RCH1; SRP1alpha; karyopherin alpha 2 (RAG cohort 1, importin alpha 1); RAG cohort 1; importin alpha 1; importin alpha 2; importin-alpha-P1; karyopherin alpha 2; pendulin; KPNA2 antibody; IPOA1 QIP2 antibody; RCH1 antibody; SRP1alpha antibody; karyopherin alpha 2 (RAG cohort 1; importin alpha 1) antibody; RAG cohort 1 antibody; importin alpha 1 antibody; importin alpha 2 antibody; importin-alpha-P1 antibody; karyopherin alpha 2 antibody; pendulin antibody; KPNA2 / IPOA1
 Product Gene Name   

anti-KPNA2 antibody

[Similar Products]
 Product Synonym Gene Name    IPOA1 [Similar Products]
 Matching Pairs    Unconjugated Antibody: KPNA2/IPOA1 (MBS421014)
Biotin Conjugated Antibody: KPNA2/IPOA1 (MBS423606)
 Antibody/Peptide Pairs    KPNA2 / IPOA1 peptide (MBS425004) is used for blocking the activity of KPNA2/IPOA1 antibody (MBS421014)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    QVQDGAPGTF NF
 OMIM    600685
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Mouse, Rat, Dog
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-QVQDGAPGTFNF, from the C Terminus of the protein sequence according to NP_002257.1.
 Epitope    C Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-KPNA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-KPNA2 antibody   

Peptide ELISA (EIA), Western Blot (WB), Immunofluorescence (IF)

 Application Notes for anti-KPNA2 antibody    Peptide ELISA: Antibody detection limit dilution 1: 8000.
Western Blot: Approx 55kDa band observed in lysates of cell line HeLa (calculated MW of 57.9kDa according to NP_002257.1). Recommended for use at 1-3ug/ml.
Immunofluorescence: In 4% formaldahyde-fixed HeLa staining is mostly cytoplasmic, with some nuclear staining and clear nuclear pore staining.
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 Western Blot (WB) of anti-KPNA2 antibody    Staining (0.1ug/ml) of Hela lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.
anti-KPNA2 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-KPNA2 antibody    Staining (top panel and green) of 4% formaldahyde-fixed HeLa with endogenously expressed HistonH2B-GFP fusion as DNA marker (mid panel and red). Data kindly provided by Francisco Iborra, MRC Mol. Haematol. Unit, Oxford.
anti-KPNA2 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for KPNA2. It may not necessarily be applicable to this product.
 NCBI GI #    4504897
 NCBI GeneID    3838
 NCBI Accession #    NP_002257.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002266.3 [Other Products]
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 UniProt Secondary Accession #    Q53YE3; Q9BRU5; B9EJD6 [Other Products]
 UniProt Related Accession #    P52292 [Other Products]
 Molecular Weight    57,862 Da
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 NCBI Official Full Name    importin subunit alpha-1
 NCBI Official Synonym Full Names    karyopherin subunit alpha 2
 NCBI Official Symbol    KPNA2 [Similar Products]
 NCBI Official Synonym Symbols   
QIP2; RCH1; IPOA1; SRP1alpha; SRP1-alpha
[Similar Products]
 NCBI Protein Information    importin subunit alpha-1
 UniProt Protein Name    Importin subunit alpha-1
 UniProt Synonym Protein Names   
Karyopherin subunit alpha-2; RAG cohort protein 1; SRP1-alpha
 UniProt Gene Name    KPNA2 [Similar Products]
 UniProt Synonym Gene Names    RCH1; SRP1 [Similar Products]
 UniProt Entry Name    IMA1_HUMAN
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 NCBI Summary for KPNA2    The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
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 UniProt Comments for KPNA2    KPNA2: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Belongs to the importin alpha family.

Protein type: Nucleoporin; Nuclear import; Karyopherin

Chromosomal Location of Human Ortholog: 17q24.2

Cellular Component: cytoplasm; cytosol; membrane; nuclear pore; nucleoplasm

Molecular Function: histone deacetylase binding; nuclear localization sequence binding; protein binding; protein transporter activity

Biological Process: DNA metabolic process; modification by virus of host cellular process; NLS-bearing substrate import into nucleus; regulation of DNA recombination
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 Research Articles on KPNA2    1. RBBP4 functions as a novel regulatory factor to increase the efficiency of importin alpha/beta-mediated nuclear import
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KPNA2 antibodyPathways associated with anti-KPNA2 antibody
 Reference Product  PubMed Publications
 KPNB1 antibody  >15 publications with KPNA2 and KPNB1
 NUP62 antibody  >1 publications with KPNA2 and NUP62
 RANBP2 antibody  >1 publications with KPNA2 and RANBP2
 NUP153 antibody  >1 publications with KPNA2 and NUP153
 Products by Pathway  Pathway Diagram
 Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies  Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 DNA Double Strand Break Response Pathway antibodies  DNA Double Strand Break Response Pathway Diagram
 DNA Double-Strand Break Repair Pathway antibodies  DNA Double-Strand Break Repair Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Host Interactions With Influenza Factors Pathway antibodies  Host Interactions With Influenza Factors Pathway Diagram
 ISG15 Antiviral Mechanism Pathway antibodies  ISG15 Antiviral Mechanism Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Infectious Disease Pathway antibodies  Infectious Disease Pathway Diagram
Diseases associated with anti-KPNA2 antibodyOrgans/Tissues associated with anti-KPNA2 antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >22 publications with KPNA2 and Carcinoma
 Breast Neoplasms Antibodies  >17 publications with KPNA2 and Breast Neoplasms
 Adenocarcinoma Antibodies  >10 publications with KPNA2 and Adenocarcinoma
 Neoplasm Metastasis Antibodies  >7 publications with KPNA2 and Neoplasm Metastasis
 Ovarian Neoplasms Antibodies  >6 publications with KPNA2 and Ovarian Neoplasms
 Carcinoma, Squamous Cell Antibodies  >6 publications with KPNA2 and Carcinoma, Squamous Cell
 Lung Neoplasms Antibodies  >6 publications with KPNA2 and Lung Neoplasms
 Inflammation Antibodies  >6 publications with KPNA2 and Inflammation
 Nervous System Diseases Antibodies  >4 publications with KPNA2 and Nervous System Diseases
 Liver Neoplasms Antibodies  >4 publications with KPNA2 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >8 publications with KPNA2 and Lung
 Lymph Node Antibodies  >7 publications with KPNA2 and Lymph Node
 Lymph Antibodies  >7 publications with KPNA2 and Lymph
 Prostate Antibodies  >7 publications with KPNA2 and Prostate
 Liver Antibodies  >6 publications with KPNA2 and Liver
 Brain Antibodies  >6 publications with KPNA2 and Brain
 Blood Antibodies  >5 publications with KPNA2 and Blood
 Muscle Antibodies  >5 publications with KPNA2 and Muscle
 Heart Antibodies  >4 publications with KPNA2 and Heart
 Embryonic Tissue Antibodies  >3 publications with KPNA2 and Embryonic Tissue
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