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anti-KPNA4 antibody :: Rabbit KPNA4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS151257
Unit / Price
0.02 mg  /  $140 +1 FREE 8GB USB
0.1 mg  /  $355 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

KPNA4, Polyclonal Antibody

 Also Known As   

KPNA4 Antibody

 Product Synonym Names    KPNA4; QIP1; SRP3; IPOA3; QIP1; Importin subunit alpha-3; Importin alpha Q1; Qip1; karyopherin alpha 4 (importin alpha 3)
 Product Gene Name   

anti-KPNA4 antibody

[Similar Products]
 Antibody/Peptide Pairs    KPNA4 peptide (MBS152573) is used for blocking the activity of KPNA4 antibody (MBS151257)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    602970
 3D Structure    ModBase 3D Structure for O00629
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    KPNA4 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    KPNA4 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human KPNA4.
 Buffer    KPNA4 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    KPNA4 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-KPNA4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-KPNA4 antibody

   KPNA4 Antibody: Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. Molecules containing the classical nuclear localization signal (NLS) are transported into the nucleus by alpha/beta heterodimers. KPNA3 has been shown to be important in the TNF-α-induced nuclear import of NF-κB. It is also involved in the stress-mediated nuclear stabilization of p53 and the nuclear import and replication of HIV-1 in both dividing and non-dividing cells.
 Applications Tested/Suitable for anti-KPNA4 antibody   

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

 Application Notes for anti-KPNA4 antibody    KPNA4 antibody can be used for detection of KPNA4 by Western blot at 1 mug/mL. Antibody can also be used for immunocytochemistry starting at 2.5 mug/mL. For immunofluorescence start at 20 mug/mL.
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 Western Blot (WB) of anti-KPNA4 antibody    Western blot analysis of KPNA4 in HeLa cell lysate with KPNA4 antibody at (A) 0.5 and (B) 1 μg/mL.
anti-KPNA4 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-KPNA4 antibody    Immunofluorescence of KPNA4 in HeLa cells with KPNA4 antibody at 20 μg/mL.
anti-KPNA4 antibody Immunofluorescence (IF) image
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 Immunocytochemistry (ICC) of anti-KPNA4 antibody    Immunocytochemistry of KPNA4 in HeLa cells with KPNA4 antibody at 2.5 μg/mL.
anti-KPNA4 antibody Immunocytochemistry (ICC) (ICC) image
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NCBI/Uniprot data below describe general gene information for KPNA4. It may not necessarily be applicable to this product.
 NCBI GI #    119599038
 NCBI GeneID    3840
 NCBI Accession #    EAW78632 [Other Products]
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 UniProt Primary Accession #    O00629 [Other Products]
 UniProt Secondary Accession #    O00190; A8K4S6; D3DNM2 [Other Products]
 UniProt Related Accession #    O00629 [Other Products]
 Molecular Weight    57,887 Da
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 NCBI Official Full Name    karyopherin alpha 4 (importin alpha 3), isoform CRA_b
 NCBI Official Synonym Full Names    karyopherin alpha 4 (importin alpha 3)
 NCBI Official Symbol    KPNA4 [Similar Products]
 NCBI Official Synonym Symbols   
QIP1; SRP3; IPOA3
[Similar Products]
 NCBI Protein Information    importin subunit alpha-3; importin alpha Q1; importin subunit alpha-4; karyopherin subunit alpha-4
 UniProt Protein Name    Importin subunit alpha-3
 UniProt Synonym Protein Names   
Importin alpha Q1; Qip1; Karyopherin subunit alpha-4
 UniProt Gene Name    KPNA4 [Similar Products]
 UniProt Synonym Gene Names    QIP1; Qip1 [Similar Products]
 UniProt Entry Name    IMA3_HUMAN
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 NCBI Summary for KPNA4    The nuclear import of karyophilic proteins is directed by short amino acid sequences termed nuclear localization signals (NLSs). Karyopherins, or importins, are cytoplasmic proteins that recognize NLSs and dock NLS-containing proteins to the nuclear pore complex. The protein encoded by this gene shares the sequence similarity with Xenopus importin-alpha and Saccharomyces cerevisiae Srp1. This protein is found to interact with the NLSs of DNA helicase Q1 and SV40 T antigen. [provided by RefSeq, Jul 2008]
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 UniProt Comments for KPNA4    KPNA4: an alpha importin protein that functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Forms a complex with importin beta-1 subunit.

Protein type: Nuclear import; Adaptor/scaffold; Karyopherin; Chaperone

Chromosomal Location of Human Ortholog: 3q25.33

Cellular Component: nucleoplasm; cytosol

Molecular Function: protein binding; protein transporter activity

Biological Process: response to hydrogen peroxide; cytokine and chemokine mediated signaling pathway; NLS-bearing substrate import into nucleus
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 Research Articles on KPNA4    1. miR-223 downregulation promotes glomerular endothelial cell activation by upregulating importin alpha4 and alpha5 in IgA nephropathy
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KPNA4 antibodyPathways associated with anti-KPNA4 antibody
 Reference Product  PubMed Publications
 KPNB1 antibody  >2 publications with KPNA4 and KPNB1
 RCC1 antibody  >2 publications with KPNA4 and RCC1
 TP53 antibody  >1 publications with KPNA4 and TP53
 RECQL antibody  >1 publications with KPNA4 and RECQL
 Products by Pathway  Pathway Diagram
 Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies  Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 ISG15 Antiviral Mechanism Pathway antibodies  ISG15 Antiviral Mechanism Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
 Leptin Signaling Pathway antibodies  Leptin Signaling Pathway Diagram
Diseases associated with anti-KPNA4 antibodyOrgans/Tissues associated with anti-KPNA4 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >4 publications with KPNA4 and Inflammation
 Necrosis Antibodies  >3 publications with KPNA4 and Necrosis
 Lung Neoplasms Antibodies  >1 publications with KPNA4 and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >1 publications with KPNA4 and Neoplasms, Experimental
 Brain Diseases Antibodies  >1 publications with KPNA4 and Brain Diseases
 Disease Models, Animal Antibodies  >1 publications with KPNA4 and Disease Models, Animal
 Learning Disorders Antibodies  >1 publications with KPNA4 and Learning Disorders
 Liver Diseases Antibodies  >1 publications with KPNA4 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >4 publications with KPNA4 and Brain
 Blood Antibodies  >3 publications with KPNA4 and Blood
 Lung Antibodies  >3 publications with KPNA4 and Lung
 Skin Antibodies  >2 publications with KPNA4 and Skin
 Muscle Antibodies  >2 publications with KPNA4 and Muscle
 Vascular Antibodies  >2 publications with KPNA4 and Vascular
 Liver Antibodies  >1 publications with KPNA4 and Liver
 Stomach Antibodies  >1 publications with KPNA4 and Stomach
 Mouth Antibodies  >1 publications with KPNA4 and Mouth
 Intestine Antibodies  >1 publications with KPNA4 and Intestine
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