NP_757384
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Predicted: 51 kDa
Observed: 54 kDa
NCBI Official Full Name
kremen protein 2 isoform d
NCBI Official Synonym Full Names
kringle containing transmembrane protein 2
NCBI Official Synonym Symbols
NCBI Protein Information
kremen protein 2; dickkopf receptor 2; kringle domain-containing transmembrane protein 2; kringle-containing protein marking the eye and the nose
UniProt Protein Name
Kremen protein 2
UniProt Synonym Protein Names
Dickkopf receptor 2; Kringle domain-containing transmembrane protein 2; Kringle-containing protein marking the eye and the nose
UniProt Synonym Gene Names
UniProt Entry Name
KREM2_HUMAN
NCBI Summary for KREMEN2
This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
UniProt Comments for KREMEN2
KREMEN2: Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. Forms a ternary complex with Dkk1 and LRP6 and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the plasma membrane. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 16p13.3
Cellular Component: membrane; early endosome membrane; plasma membrane; integral to membrane
Biological Process: Wnt receptor signaling pathway; cell communication
Research Articles on KREMEN2
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Products associated with anti-KREMEN2 antibody
Pathways associated with anti-KREMEN2 antibody
Diseases associated with anti-KREMEN2 antibody
Organs/Tissues associated with anti-KREMEN2 antibody
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