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anti-KRT5 antibody :: Rabbit KRT5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS127240
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

KRT5, Polyclonal Antibody

 Also Known As   

KRT5 Polyclonal Antibody

 Product Synonym Names    K5; CK5; DDD; EBS2; KRT5A
 Product Gene Name   

anti-KRT5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 609352
 3D Structure    ModBase 3D Structure for P13647
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human KRT5
 Calculated Molecular Weight    62kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-KRT5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-KRT5 antibody

   The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
 Product Categories/Family for anti-KRT5 antibody    Polyclonal
 Applications Tested/Suitable for anti-KRT5 antibody   

Western Blot (WB), Immunofluorescence (IF)

 Application Notes for anti-KRT5 antibody    WB: 1:500 - 1:2000
IF: 1:50 - 1:200
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 Western Blot (WB) of anti-KRT5 antibody    Western blot analysis of extracts of various cell lines, using KRT5 antibody.
anti-KRT5 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-KRT5 antibody    Immunofluorescence analysis of HeLa cell using KRT5 antibody
anti-KRT5 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for KRT5. It may not necessarily be applicable to this product.
 NCBI GI #    143811411
 NCBI GeneID    3852
 NCBI Accession #    P13647.3 [Other Products]
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 UniProt Primary Accession #    P13647 [Other Products]
 UniProt Secondary Accession #    Q6PI71; Q6UBJ0; Q8TA91 [Other Products]
 UniProt Related Accession #    P13647 [Other Products]
 Molecular Weight    590
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 NCBI Official Full Name    Keratin, type II cytoskeletal 5
 NCBI Official Synonym Full Names    keratin 5
 NCBI Official Symbol    KRT5 [Similar Products]
 NCBI Official Synonym Symbols   
K5; CK5; DDD; DDD1; EBS2; KRT5A
[Similar Products]
 NCBI Protein Information    keratin, type II cytoskeletal 5; CK-5; cytokeratin-5; 58 kda cytokeratin; type-II keratin Kb5; epidermolysis bullosa simplex 2 Dowling-Meara/Kobner/Weber-Cockayne types; keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types)
 UniProt Protein Name    Keratin, type II cytoskeletal 5
 UniProt Synonym Protein Names   
58 kDa cytokeratin; Cytokeratin-5; CK-5; Keratin-5; K5; Type-II keratin Kb5
 Protein Family    Keratin
 UniProt Gene Name    KRT5 [Similar Products]
 UniProt Synonym Gene Names    CK-5; K5 [Similar Products]
 UniProt Entry Name    K2C5_HUMAN
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 NCBI Summary for KRT5    The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]
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 UniProt Comments for KRT5    K5: Heterotetramer of two type I and two type II keratins. Keratin-5 associates with keratin-14. Interacts with TCHP. Belongs to the intermediate filament family.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 12q13.13

Cellular Component: mitochondrion; membrane; cytoplasm; keratin filament; plasma membrane; intermediate filament; cytosol; nucleus

Molecular Function: protein binding; structural constituent of cytoskeleton

Biological Process: epidermis development; hemidesmosome assembly

Disease: Epidermolysis Bullosa Simplex, Localized; Epidermolysis Bullosa Simplex, Generalized; Dowling-degos Disease 1; Epidermolysis Bullosa Simplex With Migratory Circinate Erythema; Epidermolysis Bullosa Simplex, Autosomal Recessive 1; Epidermolysis Bullosa Simplex With Mottled Pigmentation; Epidermolysis Bullosa Simplex, Dowling-meara Type
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 Research Articles on KRT5    1. We present six cases from two unrelated Spanish families each with several affected members with epidermolysis bullosa simplex with mottled pigmentation.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KRT5 antibodyPathways associated with anti-KRT5 antibody
 Reference Product  PubMed Publications
 KRT14 antibody  >93 publications with KRT5 and KRT14
 ERBB2 antibody  >86 publications with KRT5 and ERBB2
 JUN antibody  >77 publications with KRT5 and JUN
 EGFR antibody  >66 publications with KRT5 and EGFR
 CALB2 antibody  >20 publications with KRT5 and CALB2
 KRT18 antibody  >5 publications with KRT5 and KRT18
 FOS antibody  >3 publications with KRT5 and FOS
 AMELX antibody  >1 publications with KRT5 and AMELX
 Products by Pathway  Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
Diseases associated with anti-KRT5 antibodyOrgans/Tissues associated with anti-KRT5 antibody
 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >286 publications with KRT5 and Carcinoma
 Breast Neoplasms Antibodies  >183 publications with KRT5 and Breast Neoplasms
 Adenocarcinoma Antibodies  >157 publications with KRT5 and Adenocarcinoma
 Epidermolysis Bullosa Simplex Antibodies  >134 publications with KRT5 and Epidermolysis Bullosa Simplex
 Congenital Abnormalities Antibodies  >132 publications with KRT5 and Congenital Abnormalities
 Hyperplasia Antibodies  >81 publications with KRT5 and Hyperplasia
 Carcinoma, Basal Cell Antibodies  >78 publications with KRT5 and Carcinoma, Basal Cell
 Lung Neoplasms Antibodies  >63 publications with KRT5 and Lung Neoplasms
 Inflammation Antibodies  >46 publications with KRT5 and Inflammation
 Cell Transformation, Neoplastic Antibodies  >35 publications with KRT5 and Cell Transformation, Neoplastic
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >325 publications with KRT5 and Skin
 Lung Antibodies  >82 publications with KRT5 and Lung
 Blood Antibodies  >52 publications with KRT5 and Blood
 Embryonic Tissue Antibodies  >44 publications with KRT5 and Embryonic Tissue
 Prostate Antibodies  >40 publications with KRT5 and Prostate
 Muscle Antibodies  >39 publications with KRT5 and Muscle
 Mouth Antibodies  >31 publications with KRT5 and Mouth
 Thymus Antibodies  >28 publications with KRT5 and Thymus
 Bladder Antibodies  >25 publications with KRT5 and Bladder
 Thyroid Antibodies  >25 publications with KRT5 and Thyroid
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