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anti-KRT6A antibody :: Rabbit KRT6A Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2517411
Immunohistochemistry (IHC)
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

KRT6A, Polyclonal Antibody

★Popular Item★
 Also Known As   

KRT6A Polyclonal Antibody

 Product Synonym Names    K6A, K6C, K6D, CK6A, CK6C, CK6D, KRT6C, KRT6D
 Product Gene Name   

anti-KRT6A antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    148041
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Antigen affinity purification
 Concentration    0.5mg/mL (lot specific)
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 Immunogen    Recombinant protein of human KRT6A
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
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 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-KRT6A antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-KRT6A antibody

   The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
 Applications Tested/Suitable for anti-KRT6A antibody   

ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-KRT6A antibody    IHC: 1:25-1:100
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 Immunohistochemistry (IHC) of anti-KRT6A antibody    Immunohistochemistry of paraffin-embedded Human breast cancer tissue using KRT6A Polyclonal Antibody at dilution 1:25
anti-KRT6A antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for KRT6A. It may not necessarily be applicable to this product.
 NCBI GI #    5031839
 NCBI GeneID    3853
 NCBI Accession #    NP_005545.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_005554.3 [Other Products]
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 UniProt Secondary Accession #    P48667; Q08AR4; Q6NT67; Q96CL4; A4QPC1 [Other Products]
 UniProt Related Accession #    P02538 [Other Products]
 Molecular Weight    60,045 Da
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 NCBI Official Full Name    keratin, type II cytoskeletal 6A
 NCBI Official Synonym Full Names    keratin 6A, type II
 NCBI Official Symbol    KRT6A [Similar Products]
 NCBI Official Synonym Symbols   
K6A; K6C; K6D; PC3; CK6A; CK6C; CK6D; KRT6C; KRT6D
[Similar Products]
 NCBI Protein Information    keratin, type II cytoskeletal 6A; KDAMP; cytokeratin 6A; cytokeratin 6C; cytokeratin 6D; kamp-keratin derived antimicrobial peptide; keratin 6A, , type II; keratin, epidermal type II, K6A; type-II keratin Kb6
 UniProt Protein Name    Keratin, type II cytoskeletal 6A
 UniProt Synonym Protein Names   
Cytokeratin-6A; CK-6A; Cytokeratin-6D; CK-6D; Keratin-6A; K6A; Type-II keratin Kb6; Allergen: Hom s 5
 Protein Family    Keratin
 UniProt Gene Name    KRT6A [Similar Products]
 UniProt Synonym Gene Names    K6A; KRT6D; CK-6A; CK-6D; K6A [Similar Products]
 UniProt Entry Name    K2C6A_HUMAN
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 NCBI Summary for KRT6A    The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. In addition, peptides from the C-terminal region of the protein have antimicrobial activity against bacterial pathogens. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Oct 2014]
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 UniProt Comments for KRT6A    K6a: a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. There are two types of cytoskeletal and microfibrillar keratin: type I (acidic; 40-55 kDa) [K9 to K20] and type II (neutral to basic; 56-70 kDa) [K1 to K8]. Both a basic and an acidic keratin are required for filament assembly. Associates with K16 and/or -17.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 12q13.13

Cellular Component: membrane; keratin filament; nucleus

Molecular Function: protein binding; structural constituent of cytoskeleton

Biological Process: wound healing; positive regulation of cell proliferation; morphogenesis of an epithelium; cell differentiation

Disease: Pachyonychia Congenita 3
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 Research Articles on KRT6A    1. Keratin-derived antimicrobial peptides (KDAMPs) and their synthetic analogs exhibit antimicrobial activity against bacterial pathogens.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KRT6A antibodyDiseases associated with anti-KRT6A antibody
 Reference Product  PubMed Publications
 KRT6B antibody  >31 publications with KRT6A and KRT6B
 KRT17 antibody  >20 publications with KRT6A and KRT17
 Disease Name  Pubmed Publications
 Pachyonychia Congenita Antibodies  >35 publications with KRT6A and Pachyonychia Congenita
 Carcinoma Antibodies  >12 publications with KRT6A and Carcinoma
 Breast Neoplasms Antibodies  >8 publications with KRT6A and Breast Neoplasms
 Lung Neoplasms Antibodies  >5 publications with KRT6A and Lung Neoplasms
 Carcinoma, Squamous Cell Antibodies  >4 publications with KRT6A and Carcinoma, Squamous Cell
 Neoplasm Invasiveness Antibodies  >4 publications with KRT6A and Neoplasm Invasiveness
 Lung Diseases Antibodies  >4 publications with KRT6A and Lung Diseases
 Neoplasm Metastasis Antibodies  >3 publications with KRT6A and Neoplasm Metastasis
 Precancerous Conditions Antibodies  >2 publications with KRT6A and Precancerous Conditions
 Neoplasms, Experimental Antibodies  >2 publications with KRT6A and Neoplasms, Experimental
Organs/Tissues associated with anti-KRT6A antibody
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >23 publications with KRT6A and Skin
 Lung Antibodies  >5 publications with KRT6A and Lung
 Muscle Antibodies  >2 publications with KRT6A and Muscle
 Kidney Antibodies  >2 publications with KRT6A and Kidney
 Lymph Node Antibodies  >2 publications with KRT6A and Lymph Node
 Vascular Antibodies  >1 publications with KRT6A and Vascular
 Mammary Gland Antibodies  >1 publications with KRT6A and Mammary Gland
 Thyroid Antibodies  >1 publications with KRT6A and Thyroid
 Mouth Antibodies  >1 publications with KRT6A and Mouth
 Prostate Antibodies  >1 publications with KRT6A and Prostate
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