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anti-KLK1 antibody :: Rabbit anti-Human Kallikrein 1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS175239
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Kallikrein 1 (KLK1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-Kallikrein 1 antibody

 Product Synonym Names    Kallikrein-1; kallikrein 1; Glandular kallikrein 1 antibody; hK 1 antibody; hK1 antibody; Kallikrein serine protease 1 antibody; Kallikrein-1 antibody; Kidney/pancreas/salivary gland kallikrein antibody; Klk 6 antibody; KLK1 antibody; KLK1_HUMAN antibody; Klk6 antibody; KLKR antibody; Tissue kallikrein antibody
 Product Gene Name   

anti-KLK1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    147910
 3D Structure    ModBase 3D Structure for P06870
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence in the middle region of human Kallikrein 1 (182-197aa NDECKKAHVQKVTDFM).
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-KLK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-KLK1 antibody

   Description: Rabbit IgG polyclonal antibody for Kallikrein-1(KLK1) detection. Tested with WB, IHC-P in Human.
Background: KLK1(KALLIKREIN 1), also called KLKR, is a protein that in humans is encoded by the KLK1 gene. KLK1 is a member of the peptidase S1 family. KLK1 is a serine protease that generates Lys-bradykinin by specific proteolysis of kininogen-1. The KLK1 gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19 and its exact cytogenetic location is 19q13.33. The KLK1 gene contains 5 coding exons. And KLK1 is the most centromeric gene in the cluster. Mice lacking tissue kallikrein are unable to generate significant levels of kinins in most tissues and develop cardiovascular abnormalities early in adulthood despite normal blood pressure. The protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen.
 Applications Tested/Suitable for anti-KLK1 antibody   

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

 Application Notes for anti-KLK1 antibody    WB: 0.1-0.5ug/ml (Species: Human)
IHC-P: 0.5-1ug/ml (Species: Human) (Antigen Retrieval: By Heat)
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 Western Blot (WB) of anti-KLK1 antibody    Anti-Kallikrein 1 antibody, MBS175239, Western blotting
Lane 1: Recombinant Human KLK1 Protein 10ng
Lane 2: Recombinant Human KLK1 Protein 5ng
Lane 3: Recombinant Human KLK1 Protein 2.5ng
anti-KLK1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-KLK1 antibody    Anti-Kallikrein 1 antibody, MBS175239, IHC(P)
IHC(P): Human Pancreatic Cancer Tissue
anti-KLK1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for KLK1. It may not necessarily be applicable to this product.
 NCBI GI #    269849612
 NCBI GeneID    3816
 NCBI Accession #    P06870.2 [Other Products]
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 UniProt Primary Accession #    P06870 [Other Products]
 UniProt Secondary Accession #    Q66US9; Q86U61; Q8TCV8; Q9BS53; Q9NQU4; Q9UD19; Q9UMJ1 [Other Products]
 UniProt Related Accession #    P06870 [Other Products]
 Molecular Weight    23,835 Da
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 NCBI Official Full Name    Kallikrein-1
 NCBI Official Synonym Full Names    kallikrein 1
 NCBI Official Symbol    KLK1 [Similar Products]
 NCBI Official Synonym Symbols   
hK1; KLKR; Klk6
[Similar Products]
 NCBI Protein Information    kallikrein-1; tissue kallikrein; glandular kallikrein 1; kallikrein serine protease 1; kallikrein 1, renal/pancreas/salivary; kidney/pancreas/salivary gland kallikrein
 UniProt Protein Name    Kallikrein-1
 UniProt Synonym Protein Names   
Kidney/pancreas/salivary gland kallikrein; Tissue kallikrein
 Protein Family    Kallikrein 1-related peptidase
 UniProt Gene Name    KLK1 [Similar Products]
 UniProt Entry Name    KLK1_HUMAN
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 NCBI Summary for KLK1    Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. This protein is functionally conserved in its capacity to release the vasoactive peptide, Lys-bradykinin, from low molecular weight kininogen. [provided by RefSeq, Jul 2008]
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 UniProt Comments for KLK1    KLK1: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin. Belongs to the peptidase S1 family. Kallikrein subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Protease; EC 3.4.21.35

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: nucleus

Molecular Function: serine-type endopeptidase activity

Biological Process: proteolysis

Disease: Kallikrein, Decreased Urinary Activity Of
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 Research Articles on KLK1    1. These data do not support a role for the Tissue kallikrein-kinin system, protective or deleterious, in the development of insulin resistance and diabetes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-KLK1 antibodyPathways associated with anti-KLK1 antibody
 Reference Product  PubMed Publications
 IL4I1 antibody  >1 publications with KLK1 and IL4I1
 Products by Pathway  Pathway Diagram
 Blood Clotting Cascade Pathway antibodies  Blood Clotting Cascade Pathway Diagram
 Endocrine And Other Factor-regulated Calcium Reabsorption Pathway antibodies  Endocrine And Other Factor-regulated Calcium Reabsorption Pathway Diagram
 Endocrine And Other Factor-regulated Calcium Reabsorption Pathway antibodies  Endocrine And Other Factor-regulated Calcium Reabsorption Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway antibodies  Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway Diagram
Diseases associated with anti-KLK1 antibodyOrgans/Tissues associated with anti-KLK1 antibody
 Disease Name  Pubmed Publications
 Vascular Diseases Antibodies  >19 publications with KLK1 and Vascular Diseases
 Kidney Diseases Antibodies  >17 publications with KLK1 and Kidney Diseases
 Hypertension Antibodies  >15 publications with KLK1 and Hypertension
 Inflammation Antibodies  >8 publications with KLK1 and Inflammation
 Brain Diseases Antibodies  >8 publications with KLK1 and Brain Diseases
 Lung Diseases Antibodies  >7 publications with KLK1 and Lung Diseases
 Heart Diseases Antibodies  >6 publications with KLK1 and Heart Diseases
 Fibrosis Antibodies  >5 publications with KLK1 and Fibrosis
 Renal Insufficiency Antibodies  >4 publications with KLK1 and Renal Insufficiency
 Acute Kidney Injury Antibodies  >3 publications with KLK1 and Acute Kidney Injury
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >25 publications with KLK1 and Kidney
 Skin Antibodies  >19 publications with KLK1 and Skin
 Heart Antibodies  >6 publications with KLK1 and Heart
 Salivary Gland Antibodies  >5 publications with KLK1 and Salivary Gland
 Pancreas Antibodies  >4 publications with KLK1 and Pancreas
 Intestine Antibodies  >2 publications with KLK1 and Intestine
 Ovary Antibodies  >2 publications with KLK1 and Ovary
 Thyroid Antibodies  >2 publications with KLK1 and Thyroid
 Bone Antibodies  >1 publications with KLK1 and Bone
 Uncharacterized Tissue Antibodies  >1 publications with KLK1 and Uncharacterized Tissue
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