NP_001230055.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
27,525 Da
NCBI Official Full Name
kallikrein-7 isoform 3
NCBI Official Synonym Full Names
kallikrein-related peptidase 7
NCBI Protein Information
kallikrein-7; signal protein; serine protease 6; stratum corneum chymotryptic enzyme; kallikrein 7 (chymotryptic, stratum corneum)
UniProt Protein Name
Kallikrein-7
UniProt Synonym Protein Names
Serine protease 6; Stratum corneum chymotryptic enzyme
UniProt Synonym Gene Names
UniProt Entry Name
KLK7_HUMAN
NCBI Summary for KLK7
This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. [provided by RefSeq, May 2011]
UniProt Comments for KLK7
KLK7: May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. SCCE cleaves insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. Belongs to the peptidase S1 family. Kallikrein subfamily. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Secreted, signal peptide; Secreted; EC 3.4.21.35; Protease
Chromosomal Location of Human Ortholog: 19q13.41
Cellular Component: extracellular region
Molecular Function: serine-type peptidase activity; serine-type endopeptidase activity
Biological Process: extracellular matrix disassembly; epidermis development; extracellular matrix organization and biogenesis; proteolysis
Research Articles on KLK7
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Products associated with anti-KLK7 antibody
Pathways associated with anti-KLK7 antibody
Diseases associated with anti-KLK7 antibody
Organs/Tissues associated with anti-KLK7 antibody
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